Synthetic Studies on d-Biotin, Part 9 : An Improved Asymmetric Synthetic Route to d-Biotin via Hoffmann-Roche Lactone-Thiolactone Approach

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概要

• 論文の詳細を見る

• An efficient and highly stereoselective total synthesis of d-biotin has been achieved starting from cis-1,3-dibenzyl-2-imidazolidone-4,5-dicarboxylic acid (2) with an overall yield of 33%. Polymer-supported oxazaboroli-dine-catalyzed asymmetric reduction of meso-cyclic imide 4 constitutes the key synthetic step in introducing stereogenic centers into the d-biotin molecule.

• 公益社団法人日本薬学会の論文
• 2005-07-01

著者

• CHEN Fen-Er

  Department of Chemistry, Fudan University

• ZHAO Jian

  Department of Biochemistry and Molecular Biology, Nihon University School of Dentistry at Matsudo

• Chen Fen-er

  Department Of Chemistry Fudan University

• Chen Fen

  Department Of Chemistry Fudan University

• Chen Xu

  School Of Pharmaceutical Engineering Shenyang Pharmaceutical University

• Dai Hui

  Department Of Chemistry Fudan University

• Jia Hui

  Department Of Chemistry Fudan University

• XIE Bin

  Department of Chemistry, Fudan University

• KUANG Yun

  Department of Chemistry, Fudan University

• Zhao Jian

  Department Of Biochemistry And Molecular Biology Nihon University School Of Dentistry At Matsudo

• Zhao Jian

  Department Of Chemistry Fudan University

• Xie Bin

  Department Of Chemistry Fudan University

• Kuang Yun

  Department Of Chemistry Fudan University

• Chen Xu-Xiang

  School of Pharmaceutical Engineering, Shenyang Pharmaceutical University

• Jia Hui-Qing

  Department of Chemistry, Fudan University

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