Determination of Growth Fraction Index in Mammary Carcinoma Using MIB-1 Monoclonal Antibody : Estimation of Whole Tumor Proliferative Potential Using Biopsy Specimens
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概要
- 論文の詳細を見る
We labeled the Ki-67 antigen in mammary carcinomas, using a MIB-1 monoclonal antibody, to evaluate the usefulness of MIB-1 Ki-67 Growth Fraction Indices (GFI; number of Ki-67 positive cells/total number of cells) of biopsy specimens in estimating the proliferative potential of the carcinomas. Formalin-fixed paraffin sections prepared from biopsy material, primary tumors, and axillary lymph nodes of ten invasive mammary carcinomas were chosen for immunohistochemical study. Bound antibody was detected using the avidin-biotin-complex peroxidase method. The GFI of the resected mammary carcinomas was similar to the estimated values based on the GFI of the biopsy specimens. The GFIs of the metastatic nodes in seven of the carcinomas were similar to those of the primary carcinomas, whereas two carcinomas yielded significantly different GFIs in the metastatic foci. These results suggest that the GFI of a mammary carcinoma biopsy specimen may reflect the proliferative ability of the whole carcinoma.
- 東海大学の論文
著者
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Osamura Robert
Department of Pathology, Tokai University School of Medicine
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KANDA Hiroshi
Department of Pediatrics and Child Health, Kurume University School of Medicine
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SHIBUYA Makoto
Department of Pathology, Tokai University Hachioji Hospital
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Oda Koji
名古屋大学 腫瘍外科
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ODA Koji
Department of Surgery, Division of Surgical Oncology, Nagoya University, Graduate School of Medicine
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SUZUKI Masayasu
Department of Biochemical Engineering and Science, Faculty of Computer Science and Systems Engineeri
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Kishikawa S
Azabu Univ.
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Osamura Robert
Department Of Pathology School Of Medicine Tokai University
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Kamiya Satoaki
Department Of Surgery And Pathology Anjo Kosei Hospital
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Shibuya Makoto
Department Of Pathology School Of Medicine Tokai University
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YOKOI Shunpei
Department of Surgery and Pathology, Anjo Kosei Hospital
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HORISAWA Minoru
Department of Surgery and Pathology, Anjo Kosei Hospital
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NIINOMI Noriji
Department of Surgery and Pathology, Anjo Kosei Hospital
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HAYAKAWA Seijun
Department of Surgery and Pathology, Anjo Kosei Hospital
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KISHIKAWA Seigo
Environmental Pathology, School of Environmental Health, Azabu University
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Yokoi Shunpei
Department Of Surgery And Pathology Anjo Kosei Hospital
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Niinomi Noriji
Department Of Surgery And Pathology Anjo Kosei Hospital
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Horisawa Minoru
Department Of Surgery And Pathology Anjo Kosei Hospital
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Hayakawa Seijun
Department Of Surgery And Pathology Anjo Kosei Hospital
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Hayakawa Seijun
Department Of Pathology Anjo Kosei Hospital
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Oda Koji
Department Of Gastroenterology Graduate School Of Comprehensive Human Sciences University Of Tsukuba
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Kanda H
National Inst. Polar Res. Tokyo Jpn
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Suzuki Masayasu
Department Of Surgery And Pathology Anjo Kosei Hospital
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Suzuki Masayasu
Department Of Biochemical Engineering And Science Faculty Of Computer Science And Systems Engineerin
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Kanda Hiroshi
Department Of Applied Physics Faculty Of Engineering University Of Tokyo:(present Address)central La
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Oda K
Tokai Univ.
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