Citrus Auraptene Reduces Helicobacter pylori Colonization of Glandular Stomach Lesions in Mongolian Gerbils
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概要
- 論文の詳細を見る
We examined the efficacy of auraptene (AUR), an antioxidant agent of a citrus coumarin derivative, for suppressing gastric inflammation introduced by Helicobacter pylori (Hp) infection in Mongolian gerbils (MGs). Hp-infected MGs were placed on diets containing 100 or 500 ppm AUR for 7 weeks. Real-time PCR was used to estimate the Hp population in glandular stomach lesions, and a histological assessment of inflammation was performed. At a dose of 500 ppm, AUR reduced the Hp population to 21.9±12.0% of the control group (p<0.05). However, no apparent differences were seen in hematoxylin and eosin sections between AUR-administered and control groups. We conclude that dietary supplementation with 500 ppm of AUR suppresses Hp colonization, but does not reduce gastric inflammation.
- 日本油化学会の論文
著者
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TANAKA Takuji
Department of Oncologic Pathology, Kanazawa Medical University
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Tsutsumi Yutaka
First Dep. Of Pathology Fujita Health Univ. School Of Medicine
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ODA Koji
Department of Surgery, Division of Surgical Oncology, Nagoya University, Graduate School of Medicine
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KAKUDO Kennichi
Second Department of Pathology, Wakayama Medical University School of Medicine
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Tanaka Takuji
Department Of Oncologic Pathology Kanazawa Medical University
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Okuno Yoshiharu
Second Dep. Of Pathology Wakayama Medical Univ.
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Utsunomiya Hirotoshi
Department Of Pathology Wakayama Medical University
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Takeda Koichi
Second Department of Pathology, Wakayama Medical University
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Utsunomiya Hirotoshi
Central Research Center, Wakayama Medical University
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Kakiuchi Seiji
Second Department of Pathology, Wakayama Medical University
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Inada Ken-ichi
First Department of Pathology, Fujita Health University School of Medicine
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Takeda Koichi
筑波大学 人間総合科学研究科消化器病態医学
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Oda Koji
Department Of Gastroenterology Graduate School Of Comprehensive Human Sciences University Of Tsukuba
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Utsunomiya Hirotoshi
Department Of Strategic Surveillance For Functional Food And Comprehensive Traditional Medicine Waka
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Kakudo Kennichi
Second Department of Pathology, Wakayama Medical University
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Oda Koji
Department of Surgery, Nagoya University Graduate School of Medicine
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Okuno Yoshiharu
Second Department of Pathology, Wakayama Medical University
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Tanaka Takuji
Department of Endoscopic and Photodynamic Medicine, Hamamatsu University School of Medicine
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