Treatment of infantile hepatoblastoma and related complications
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概要
- 論文の詳細を見る
Hepatorblastoma is an uncommon childhood malignant tumor of hepatic origin and recent progress of treatment strategy resulted in improved prognosis of patients with hepatoblastoma. Although patients within one year of age were considered to have better prognosis than those over that age, the treatment related deaths have been reported to be the only cause of the treatment failure of the infantile hepatoblastoma. We have successfully treated 4 infants including one with spontaneous rupture and the other with recurrence. Treatment protocol was preoperative chemotherapy using cisplatin and THP-ADR, doses of which were modified according to the age, with optional radiological interventions followed by resection of the primary tumor. This report would describe their clinical courses and experienced side effects of the treatment in order to demonstrate its risk. Trans-arterial embolizations were beneficial to stop bleeding due to rupture and to reduce intraoperative blood loss. In spite of dose modifications high hematological side effects were inevitable and cisplatn-induced hearing loss persisted in one case. In coclusion, for small infants with hepatoblastoma, controlling the inevitable side effects and active but strategic surgical and radiological interventions are essential for successful treatment.
- 東海大学の論文
著者
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Hirakawa Hitoshi
Department of Pediatric Surgery, Tokai University School of Medicine
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Ueno Shigeru
Department of Pediatric Surgery, Tokai University School of Medicine
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IMAI Yutaka
Department of Clinical Pharmacology and Therapeutics, Tohoku University
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Imai Yutaka
Department Of Clinical Pharmacology And Therapeutics Tohoku University
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Kawabe Mayumi
Dims Institute Of Medical Science
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MAKUUCHI HIROYASU
Department of Cardiovascular Surgery, Tokai University Hospital
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Yasuda S
Himedic Imaging Center At Lake Yamanaka
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Yasuda Seiei
東海大学 医学部外科学
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YOKOYAMA Seishichi
Department of General Surgery, School of Medicine, Tokai University
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Oida Yasuhisa
Department Of Surgery Tokai University School Of Medicine
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Tobita K
Department Of Surgery Tokai University School Of Medicine
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Tobita Kosuke
Tokai Univ. School Of Medicine
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IMAIZUMI TOSHIHIDE
Department of Gastroenterological Surgery, Tokyo Women's Medical University
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Yasuda Seiei
Himedic Imaging Center At Lake Yamanaka Keio University School Of Medicine
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OHTANI Yasuo
Departments of Surgery, Tokai University School of Medicine
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HANAUE Hitoshi
Departments of Surgery Tokai University Oiso Hospital
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Makuuchi Hiroyasu
Department Of Surgery School Of Medicine Tokai University
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Makuuchi Hiroyasu
Department Of Cardiovascular Surgery Tokai University Hospital
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Imaizumi Toshihide
Department Of Gastroenterological Surgery Tokyo Women's Medical University
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Imaizumi Toshihide
Department Of Surgery Tokai University School Of Medicine
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IWATA Yoshio
Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medi
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Imai Yutaka
Department Of Pediatric Surgery Gastrointestinal Surgery And Radiology Tokai University School Of Me
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Ohtani Yasuo
Department Of Surgery Tokai University School Of Medicine
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Iwata Yoshio
Department Of Human And Mechanical Systems Engineering Kanazawa University
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Iwata Yoshio
Department Of Pediatric Surgery Gastrointestinal Surgery And Radiology Tokai University School Of Me
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Ueno Shigeru
Department Of Pediatric Surgery Gastrointestinal Surgery And Radiology Tokai University School Of Me
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Ueno Shigeru
First Department Of Oral And Maxillofacial Surgery Osaka Dental University
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Hirakawa Hitoshi
Department Of Pediatric Surgery Gastrointestinal Surgery And Radiology Tokai University School Of Me
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HINOKI Tomoya
Department of Pediatric Surgery, Gastrointestinal Surgery and Radiology, Tokai University School of
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TOBITA Kosuke
Department of Pediatric Surgery, Gastrointestinal Surgery and Radiology, Tokai University School of
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Makuuchi H
Department Of Surgery School Of Medicine Tokai University
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Yokoyama Seishichi
Department Of Pediatric Surgery Gastrointestinal Surgery And Radiology Tokai University School Of Me
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Hinoki Tomoya
Department Of Pediatric Surgery Gastrointestinal Surgery And Radiology Tokai University School Of Me
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Yokoyama Seishichi
Department Of General Surgery School Of Medicine Tokai University
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Hirakawa Hitoshi
Department Of Orthopaedic Surgery Hirosaki University School Of Medicine
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Maruyama H
Department Of Surgery Tokai University School Of Medicine
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Oh Yasumasa
Department Of Pediatrics Tokai University School Of Medicine
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Imaizumi Toshihide
Department Of Gastroenterological Surgery Tokyo Women's Medical College
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Yamamoto Sohichirou
Department Of Surgery Tokai University School Of Medicine
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UENO Shigeru
Department of Pediatric Surgery and Gastrointestinal Surgery, Tokai University School of Medicine
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Miyashita Kayoko
DIMS Institute of Medical Science:Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences
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ASAMOTO Makoto
Department of Surgery, Tokai University School of Medicine
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IMAIDA Katsumi
Department of Surgery, Tokai University School of Medicine
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Kawabe Mayumi
Department of Surgery, Tokai University School of Medicine
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