Immunohistochemical Localization of REG Ia Protein in Salivary Gland Tumors

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概要

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• he regenerating gene( Reg) Ia protein has a trophic effect on gastric epithelial cells, and its overexpressionis reported in gastrointestinal cancers. The salivary gland is a component of the digestive system, andtherefore, REG Ia protein may play some role in the pathophysiology of salivary gland tumors. In the presentstudy, we determined the immunohistochemical localization of REG Ia protein in salivary gland tumorsand moreover investigated its relationship to clinicopathological features. Twenty-eight patients with salivarygland tumor were enrolled. The specimens resected by surgery from those patients were examinedusing immunohistochemistry for REG Ia protein and Ki67. Five of the 16 pleomorphic adenomas (31.3%)were positive for REG Ia protein. Regarding salivary gland carcinomas, four of five mucoepidermoid carcinomas(80%), three of five adenoid cystic carcinomas (60%), one of two polymorphous low-grade adenocarcinomas(50%) were also positive for REG Ia protein. However, no relationships were found betweenREG Ia protein expression and clinicopathological features. Regarding the Ki67 expression, strong signalwas observed in the tumor cells of patients with salivary gland adenoma as well as carcinoma. REG Ia proteinis expressed not only in adenocarcinoma but also precancerous adenoma cells proliferating actively,suggesting that REG Ia protein may play a role at least in part in the development of salivary gland tumors.

• 獨協医科大学の論文
• 2009-03-25

著者

• Hidetsugu Yamagishi

  Department of Surgical and Molecular Pathology,Department of Gastroenterology, Dokkyo Medical Univer

• Hirokazu Fukui

  Department of Surgical and Molecular Pathology

• Shigehiko Fujii

  Department of Surgical and Molecular Pathology

• Takahiro Fujimori

  Department of Surgical and Molecular Pathology

• Imai Yutaka

  Department Of Clinical Pharmacology And Therapeutics Tohoku University

• Tokiko Kimura

  Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine

• Akira Sekikawa

  Department of Surgical and Molecular Pathology

• Kazuhito Ichikawa

  Department of Surgical and Molecular Pathology

• Shigeki Tomita

  Department of Surgical and Molecular Pathology

• Johji Imura

  Department of Surgical and Molecular Pathology

• Hitoshi Kawamata

  Department of Oral Surgery, Dokkyo Medical University

• Yutaka Imai

  Department of Oral Surgery, Dokkyo Medical University School of Medicine

• Fujii Shigehiko

  Department Of Surgical And Molecular Pathology Dokkyo University School Of Medicine

• Ichikawa Kazuhito

  Department Of Surgery Kyowa Central Hospital

• Hidetsugu Yamagishi

  Department Of Surgical And Molecular Pathology Department Of Gastroenterology Dokkyo Medical Univers

• Hidetsugu Yamagishi

  Department Of Gastroenterology Dokkyo Medical University School Of Medicine

• Yutaka Imai

  Department Of Oral Surgery Dokkyo Medical University School Of Medicine

• Tokiko Kimura

  Department Of Surgical And Molecular Pathology Dokkyo Medical University School Of Medicine

• Sekikawa Akira

  Department Of Epidemiology Graduate School Of Public Health University Of Pittsburg

• Tomita Shigeki

  Department Of Surgical And Molecular Pathology Dokkyo University School Of Medicine

• Fujimori Takahiro

  Department Of Geriatric Medicine Osaka University Graduate School Of Medicina

• Hitoshi Kawamata

  Department Of Oral Surgery Dokkyo Medical University

• Kawamata Hitoshi

  Department Of Oral And Maxillofacial Surgery Dokkyo University School Of Medicine

• Fukui Hirokazu

  Department Of Horticulture Faculty Of Agriculture Hokkaido University

• Fujimori Takahiro

  Department of Surgical and Molecular Pathology

• Sekikawa Akira

  Department of Surgical and Molecular Pathology

• Imai Yutaka

  Department of Oral Surgery, Dokkyo Medical University School of Medicine

• Yamagishi Hidetsugu

  Department of Surgical and Molecular Pathology,Department of Gastroenterology, Dokkyo Medical University School of Medicine

• Kimura Tokiko

  Department of Surgical and Molecular Pathology, Dokkyo Medical University School of Medicine

• Kimura Tokiko

  Department of Surgical and Molecular Pathology

• Yamagishi Hidetsugu

  Department of Gastroenterology, Dokkyo Medical University School of Medicine

• Yamagishi Hidetsugu

  Department of Surgical and Molecular Pathology

• Fujii Shigehiko

  Department of Surgical and Molecular Pathology

• Tomita Shigeki

  Department of Surgical and Molecular Pathology

• Tomita Shigeki

  Department of Physical Electronics, Tokyo Institute of Technology, 2-12-1-S9-9 O-okayama, Meguro-ku, Tokyo 152-8552, Japan

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