THE ROLE OF RENAL PROSTAGLANDIN E AND KALLIKREIN IN PATHOGENESIS OF ESSENTIAL HYPERTENSION

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概要

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• The present study was done to investigate the interrelationships between renal kallikrein-kinin, renal prostaglandin E and renin-angiotensin-aldosterone systems in human and the possibility that renal kallikrein-kinin and renal prostaglandin E may participate in the pathogenesis of essential hypertension by means of measuring urinary excretion of kallikrein and prostaglandin E, plasma renin activity and plasma aldosterone concentration before and after stimulation or inhibition of the renin-angiotensin-aldosterone system and inhibition of renal prostaglandin E generation. Urinary kallikrein excretion was increased after the stimulation of the renin-angiotensin-aldosterone system by low Na diet or the administration of furosemide and upright posture, while it tended to decrease after the inhibition of the renin-angiotensin-aldosterone system by the administration of 1-sarcosine-8-isoleucine angiotensin II under sodium depletion or spironolactone. These data showed that the changes in urinary kallikrein excretion paralelled with those of the renin-angiotensin-aldosterone system following various stimuli, suggesting that renal kallikrein-kinin system may regulate blood pressure by opposing the action of the renin-angiotensin-aldosterone system. Urinary PGE excretion was decreased after sodium depletion and increased after the administration of furosemide in spite of the augmentation of the renin-angiotensin-aldosterone system. The changes in urinary PGE excretion was closely related to those in urinary Na output after various stimuli and a significant positive correlation was found between basal levels of urinary PGE and those of urinary Na, suggesting that renal prostaglandin E may be involved in the regulation of blood pressure by affecting renal sodium handing. The present data showed that basal level of urinary excretion of PGE and kallikrein was lower in essential hypertension than in normal subjects and that the release of renal kallikrein and PGE after furosemide administration was also suppressed in essential hypertension compared with that in normal subjects, suggesting that there exists an impaired defense mechanism against the renin-angiotensin-aldosterone system resulting in sodium retention.

• 社団法人日本循環器学会の論文
• 1980-01-20

著者

• IMAI Yutaka

  Department of Clinical Pharmacology and Therapeutics, Tohoku University

• CHIBA Satoru

  Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine

• Sato Makito

  The Second Department Of Internal Medicine Tohoku University School Of Medicine

• Sato Makito

  Department Of Dermatology Sapporo Medical University

• Chiba Satoru

  Department Of Cardiovascular Medicine Kushiro Rousai Hospital

• Chiba Satoru

  The Second Department Of Internal Medicine Tohoku University School Of Medicine

• Yasujima Minoru

  東北大学 医系研究内部障害学分野

• Yasujima Minoru

  Department Of Laboratory Medicine Hirosaki University Graduate School Of Medicine

• Imai Yutaka

  Department Of Clinical Pharmacology And Therapeutics Tohoku University

• Imai Yutaka

  東北大学 臨床薬学

• Yoshida K

  Furukawa City Hospital

• Inoue Taku

  Third Department On Internal Medicine University Of The Ryukyus

• Goto Toshikazu

  Department Of Neurological Surgery Nihon University School Of Medicine

• Yasujima Minoru

  Department Of Laboratory Medicine Hirosaki University School Of Medicine

• Sakurai Yutaka

  Department of Preventive Medicine and Public Health, National Defense Medical College

• Sakurai Yutaka

  The Second Department Of Internal Medicine Tohoku University School Of Medicine

• HARUYAMA TOSHIAKI

  The Second Department of Internal Medicine, Tohoku University School of Medicine

• SATO KO

  The Second Department of Internal Medicine, Tohoku University School of Medicine

• ABE KEISHI

  Department of Internal Medicine, Tohoku University School of Medicine

• ITOH TORU

  Department of Internal Medicine, Tohoku University School of Medicine

• HARUYAMA TOSHIAKI

  Department of Internal Medicine, Tohoku University School of Medicine

• OTSUKA YOICHI

  Department of Internal Medicine, Tohoku University School of Medicine

• YOSHINAGA KAORU

  Department of Internal Medicine, Tohoku University School of Medicine

• OMATA KEN

  Department of Internal Medicine, Tohoku University School of Medicine

• SATO KO

  Department of Internal Medicine, Tohoku University School of Medicine

• HIWATARI MASAO

  Department of Internal Medicine, Tohoku University School of Medicine

• OTA Kozo

  Furukawa City Hospital

• Sato Ko

  The Second Department Of Internal Medicine Tohoku University School Of Medicine

• Yasujima M

  Division Of Cardiology Department Of Internal Medicine The Jikei University School Of Medicine

• Goto Toshikazu

  The Second Department Of Internal Medicine Tohoku University School Of Medicine

• Goto Toshikazu

  Department Of Electrical Engineering Faculty Of Engineering Science Osaka University

• Abe Koji

  The Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kumamoto University

• Omata Ken

  The Second Department Of Internal Medicine Tohoku University School Of Medicine

• Abe Keishi

  Department Of Internal Medicine Tohoku University School Of Medicine

• Otsuka Yoichi

  The Second Department Of Internal Medicine Tohoku University School Of Medicine

• Sato Kazutoshi

  The Second Department Of Internal Medicine Tohoku University School Of Medicine

• Sato Kazutoshi

  The Second Department Of Internal Medicine

• Sakurai Yutaka

  Department Of Hygiene National Defense Medical College

• Itoh Toru

  Department Of Internal Medicine Tohoku University School Of Medicine

• Sato Ko

  Tohoku Univ. Sendai Jpn

• Abe K

  Tohoku University

• Yasujima Minoru

  Division Of Cardiology Department Of Internal Medicine The Jikei University School Of Medicine

• Haruyama Toshiaki

  The Second Department Of Internal Medicine Tohoku University School Of Medicine

• Saito K

  The Second Department Of Internal Medicine Tohoku University School Of Medicine

• Yoshinaga Kaoru

  Department Of Internal Medicine Tohoku University School Of Medicine

• Ichikawa Takaharu

  Department Of Urology Okayama University Medical School

• Omata K

  Furukawa City Hospital

• Omata K

  Health Administration Center Miyagi University Of Education

• Abe Keishi

  Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kumamoto University

• Yoshida Kazunori

  Department Of Internal Medicine And Rehabilitation Science Tohoku University Graduate School Of Medi

• Yoshinaga Kaoru.

  The 2nd Department Of Internal Medicine Tohoku University School Of Med

• Hiwatari Masao

  Department Of Cardiovascular Surgery Nihon University School Of Medicine

• Ota Kozo

  Division Of Nephrology Endocrinology And Vascular Medicine Tohoku University School Of Medicine

• Yasujima Minoru

  Department Of Clinical Laboratory Hirosaki University Hospital

• GOTO Toshikazu

  Depart-ment of Internal Medicne Yamagata Prefectural Central Hospital

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