Maoto, Kampo medicine, suppresses the metastatic potential of highly metastatic osteosarcoma cells
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概要
- 論文の詳細を見る
私たちはこれまでに,麻黄湯がマウス骨肉腫由来高転移性FBJ-LL細胞の運動能を抑制することを見出し,がん転移抑制効果を有する可能性があることを示唆した(J.Trad.Med., 21(4), 174-181, 2004)。本研究では,麻黄湯のがん転移に対する効果を,自然転移モデルマウスを用いて解析した。FBJ-LL細胞はマウスの皮下に移植すると原発腫瘍を生じるとともに肝臓へ自然転移する。このようなマウスに麻黄湯を自由飲水させると,原発腫瘍は生じるが肝臓への自然転移が有意に減少した。さらに,担癌マウス血清中のサイトカインの発現パターンを調べると,水投与群は多くの種類のサイトカインを発現していたのに対して,麻黄湯投与群のサイトカイン発現パターンは正常マウスに近かった。また,麻黄湯はがんの転移過程に関与しているマトリクスメタロプロテアーゼの活性化を抑制することがわかった。一方,免疫系を賦活化することによって転移を抑制することが報告されている十全大補湯は,FBJ-LL細胞により形成された原発腫瘍の増殖及び肝臓への自然転移に影響を与えなかった。これらの結果から,麻黄湯は十全大補湯と異なり,がんの転移過程に直接作用することにより,転移を抑制していることが示唆され,新たながん転移抑制剤の候補となる可能性を秘めていることがわかった。
- 和漢医薬学会の論文
著者
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NAKANISHI Hayao
Division of Oncological Pathology, Aichi Cancer Center Research Institute
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日向 須美子
北里大学 東洋医学総合研究所 臨床研究部
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日向 須美子
社団法人北里研究所東洋医学総合研究所臨床研究部
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日向 須美子
北里大学東洋医学総合研究所臨床研究部
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OIKAWA Tetsuro
Department of Clinical Research, Oriental Medicine Research Center, Kitasato University
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HYUGA Masashi
Division of Biological Chemistry and Biologicals, National Institute of Health Sciences of Biologica
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HANAWA Toshihiko
Department of Clinical Research, Oriental Medicine Research Center, The Kitasato Institute
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Ito Hidenori
Department Of Molecular Neurobiology Institute For Developmental Research Aichi Human Service Center
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Ito Hidenori
Department Of Biochemistry Institute For Developmental Research Aichi Human Service Center
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Ito Hidenori
Department Of Clinical Research Oriental Medicine Research Center Of Kitasato University
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WATANABE Koji
Department of Clinical Research, Oriental Medicine Research Center, The Kitasato Institute
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Hyuga Masashi
Division Of Biological Chemistry And Biologicals National Institute Of Health Sciences
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Watanabe Koji
Department Of Cardiology Tokyo Metropolitan Hiroo General Hospital
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Nakanishi Hayao
Division Of Oncological Pathology Aichi Cancer Center Research Institute
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Nakanishi Hayao
Division Of Oncological Phathology Aichi Cancer Center Research Institute
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日向 須美子
東京工業大学生命理工学部
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Oikawa Tetsuro
Department Of Clinical Research Oriental Medicine Research Center Kitasato University
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Oikawa Tetsuro
Department Of Clinical Research Oriental Medicine Research Center The Kitasato Institute
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Hanawa Toshihiko
Department Of Clinical Research Oriental Medicine Research Center The Kitasato Institute : Kitasato
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Ito Hidenori
Department Of Clinical Research Oriental Medicine Research Center The Kitasato Institute : Kitasato
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Ito Hidenori
Department Of Bioapplied Chemistry Osaka City University
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Watanabe Koji
Department Of Cardiology Hashima City Hospital
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Watanabe Koji
Department Of Clinical Research Oriental Medicine Research Center The Kitasato Institute : Kitasato
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Hanawa Toshihiko
Department Of Clinical Research Oriental Medicine Research Center The Kitasato Institute
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