Rosmarinic Acid from Perillae Herba Produces an Antidepressant-Like Effect in Mice through Cell Proliferation in the Hippocampus(Pharmacology)
スポンサーリンク
概要
- 論文の詳細を見る
Rosmarinic acid (RA) is one of major polyphenolic ingredients of Perillae Herba (a leaf of Perilla frutescens), and has an antidepressant-like property in animal models of depression. However, the mechanism(s) underlying this activity are unknown. Recent studies have reported that regulation of hippocampal neurogenesis is associated with the pathogenesis of depression. To elucidate the mode of action of RA-induced antidepressant-like activity, proliferative effect of RA on newborn cells in the dentate gyrus of mouse hippocampus was investigated using immunohistochemical analysis with bromodeoxyuridine (BrdU), a marker of proliferating cells. RA treatment for 7 or 14 d significantly increased in the number of BrdU-positive cells in inverse correlation with significant reductions in immobility in a forced swimming test, an animal model of depression, in a dose-dependent manner. However, locomotor activities were not affected. These results suggest that RA produces an antide-pressant-like effect at least in part via the proliferation of newborn cells in the dentate gyrus of the hippocampus.
- 公益社団法人日本薬学会の論文
- 2008-07-01
著者
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ITO Naoki
Department of Applied Chemistry, Faculty of Engineering, Kyushu University
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NAGAI Takayuki
Department of Materials Engineering Science, Graduate School of Engineering Science, Osaka Universit
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山田 陽城
北里大学北里生命科学研究所
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OIKAWA Tetsuro
Department of Clinical Research, Oriental Medicine Research Center, Kitasato University
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Ito Naoki
Department Of Applied Chemistry Faculty Of Engineering Kyushu University
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HANAWA Toshihiko
Department of Clinical Research, Oriental Medicine Research Center, The Kitasato Institute
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Nagai Takayuki
Department Of Geriatric Medicine Ehime University Graduate School Of Medicine
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GAMO Yuji
Department of Oriental Medicine, Doctoral Program of Medical Science, Kitasato University Graduate S
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YAMADA Haruki
Department of Internal Medicine, Social Insurance Chuo General Hospital
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Yamada Haruki
Dep. Of Clinical Res. Oriental Medicine Res. Center Kitasato Univ.
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Gamo Yuji
Department Of Clinical Research Oriental Medicine Research Center Kitasato University:department Of
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Oikawa Tetsuro
Kitasato Univ. Tokyo Jpn
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Oikawa Tetsuro
Department Of Clinical Research Oriental Medicine Research Center Kitasato University
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Yabe Takeshi
Department of Clinical Research, Oriental Medicine Research Center, Kitasato University
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Nagai Takayuki
Kitasato Institute For Life Sciences Kitasato University
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Ito Naoki
Kitasato Univ. Tokyo Jpn
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Oikawa Tetsuro
Dep. Of Clinical Res. Oriental Medicine Res. Center Kitasato Univ.
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Hanawa Toshihiko
Dep. Of Clinical Res. Oriental Medicine Res. Center Kitasato Univ.
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Hanawa Toshihiko
Department Of Clinical Research Oriental Medicine Research Center The Kitasato Institute : Kitasato
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Nagai Takayuki
Department Of Electrical Engineering Keio University
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Hanawa Toshihiko
Department Of Clinical Research Oriental Medicine Research Center The Kitasato Institute
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Yabe Takeshi
Department of Basic Research, Oriental Medicine Research Center, Kitasato University
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OIKAWA Tetsuro
Department of Clinical Research, Oriental Medicine Research Center of Kitasato University
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Yamada Haruki
Department of Clinical Research, Oriental Medicine Research Center, Kitasato University:Kitasato Institute for Life Sciences & Graduate School of Infection Control Sciences, Kitasato University
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NAGAI Takayuki
Department of Clinical Research, Oriental Medicine Research Center, Kitasato University:Kitasato Institute for Life Sciences & Graduate School of Infection Control Sciences, Kitasato University
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Yabe Takeshi
Department of Clinical Research, Oriental Medicine Research Center, Kitasato University:Kitasato Institute for Life Sciences & Graduate School of Infection Control Sciences, Kitasato University
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Nagai Takayuki
Department of Basic Research, Oriental Medicine Research Center, Kitasato University
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Yamada Haruki
Department of Basic Research, Oriental Medicine Research Center, Kitasato University
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