Gd-EOB-DTPA Enhanced MRI for Hepatocellular Carcinoma : Quantitative Evaluation of Tumor Enhancement in Hepatobiliary Phase
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概要
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Objective: The purpose of this study was to evaluate the utility of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) for the quantitative evaluation of hepatocellular carcinoma (HCC) and dysplastic nodules in the hepatobiliary phase. Material and Methods: The subjects comprised 12 patients with 27 lesions (22 HCCs and 5 dysplastic nodules). Chemical-shift-selective fat-suppressed T1-weighted sequences were obtained before and 10, 20, and 40 min after the injection of Gd-EOB-DTPA. Quantitative analyses were performed with the enhancement ratio of the lesion and the contrast-to-noise (C/N) ratio. Results: The enhancement ratios of the HCCs were 44.0±36.5, 44.7±46.8, and 47.7±52.8 (%) at 10, 20, and 40 min, respectively, after the injection of Gd-EOB-DTPA. The enhancement ratios of the dysplastic nodules were 36.2±34.3, 44.3±37.3, and 40.1±46.8 (%). The C/N ratios of the HCCs were 0.2±6.6 for the precontrast image, and -9.2±12.6, -9.9±14.8, and -12.7±15.7 at 10, 20, and 40 min, respectively, after the injection of Gd-EOB-DTPA. The C/N ratios of the dysplastic nodules were 1.4±8.0, -13.7±11.1, -13.3±7.6, and -13.1±10.4. No significant differences were found between the HCCs and the dysplastic nodules in the enhancement ratio and the C/N ratio. Only two HCCs showed a positive C/N ratio value, and these HCCs were pathologically confirmed to be a well differentiated and a moderately differentiated carcinoma, respectively. Conclusion: HCCs and some of the dysplastic nodules showed hypointensity in the hepatobiliary phase in Gd-EOB-DTPA-enhanced MRI. No specific enhancement was observed, regardless of tumor differentiation.
- 日本磁気共鳴医学会の論文
- 2005-06-01
著者
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ITO Naoki
Department of Applied Chemistry, Faculty of Engineering, Kyushu University
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Ito Naoki
東京医科大学 内科学第4
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Ito Naoki
Department Of Applied Chemistry Faculty Of Engineering Kyushu University
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Satani Kenichiro
Department Of Radiology Tokyo Medical University
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ABE Kimihiko
Department of Radiology, Tokyo Medical College
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Abe Kimihiko
Department Of Radiology Tokyo Medical University
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Ito Naoki
Department Of Radiology Tokyo Medical University
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SAITO Kazuhiro
Department of Radiology, Tokyo Medial University Kasumigaura Hospital
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KOTAKE Fumio
Department of Radiology, Tokyo Medial University Kasumigaura Hospital
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OZUKI Taizo
Department of Radiology, Tokyo Medical University
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MIKAMI Ryuji
Department of Radiology, Tokyo Medial University Kasumigaura Hospital
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SHIMAZAKI Yoko
Department of Radiology, Tokyo Medical University
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Ozuki Taizo
Department Of Radiology Tokyo Medical University Kasumigaura Hospital
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Mikami Ryuji
Department Of Radiology Tokyo Medial University Kasumigaura Hospital
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Kotake Fumio
Department Of Radiology Tokyo Medical University Kasumigaura Hospital
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Shimazaki Yoko
Department Of Radiology Tokyo Medical University
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Abe Kimihiko
Department Of Clinical Radiology Graduate School Of Medical Sciences Kyushu University
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Saito Kazuhiro
Department Of Radiology Tokyo Medical University
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Saito Kazuhiro
Department Of Chemistry Faculty Of Science Yamagata University
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