Detection of Hepatocellular Carcinoma with Ferucarbotran (Resovist)-enhanced Breath-hold MR Imaging : Feasibility of 10 minute-delayed Images
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概要
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Purpose: We evaluated the optimal timing for breath-hold MR imaging with bolus-injectable superparamagnetic iron oxide (SPIO) for detecting hepatocellular carcinoma (HCC). Materials and Methods: Twenty patients with 62 HCCs (52 hypervascular, 10 non-hypervascular) underwent MR imaging that included unenhanced and SPIO-enhanced T1-weighted gradient echo (GRE) and T2-weighted fast spin echo (FSE) sequences, perfusion study, and SPIO-enhanced T2*-weighted GRE sequences. We obtained SPIO-enhanced T2*-weighted sequences 10 and 30 min after injecting SPIO and made 2 image sets, comprising 10- or 30-min delayed T2*-weighted images. Three observers performed alternative free response receiver operating characteristic (AFROC) analysis, and quantitative evaluation was performed. Results: Only Observers 2 and 3 recognized a significant difference in the area under the AFROC curve (Az) value in the 10-min delayed images; no significant difference was observed in the 30-min delayed images. There was no significant difference in the sensitivity of individual observers between 10- and 30-min delayed images. The contrast-to-noise (C/N) ratio of the 30-min delayed images was significantly higher than that of the 10-min delayed images. The C/N ratio of hypervascular HCCs in the 30-min delayed images was significantly higher than in the 10-min delayed images, but that of non-hypervascular HCCs showed no significant difference. Conclusion: In most cases, 10-min delayed SPIO-enhanced T2*-weighted images are sufficient to detect HCCs.
- 2008-09-01
著者
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Satani Kenichiro
Department Of Radiology Tokyo Medical University
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SHINDO Hiroaki
Department of Radiology, Tokyo Medical College
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ABE Kimihiko
Department of Radiology, Tokyo Medical College
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Abe Kimihiko
Department Of Radiology Tokyo Medical University
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Shindo Hiroaki
Department Of Radiology Tokyo Medical University
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Shindo Hiroaki
Department Of Radiology Tokyo Medical College
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SAITO Kazuhiro
Department of Radiology, Tokyo Medial University Kasumigaura Hospital
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KOTAKE Fumio
Department of Radiology, Tokyo Medial University Kasumigaura Hospital
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OZUKI Taizo
Department of Radiology, Tokyo Medical University
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SHIMAZAKI Yoko
Department of Radiology, Tokyo Medical University
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ISHIKAWA Aimi
Department of Radiology, Tokyo Medical University
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Ozuki Taizo
Department Of Radiology Tokyo Medical University Kasumigaura Hospital
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Kotake Fumio
Department Of Radiology Tokyo Medical University Kasumigaura Hospital
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Ishikawa Aimi
Department Of Radiology Tokyo Medical University
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Shimazaki Yoko
Department Of Radiology Tokyo Medical University
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Abe Kimihiko
Department Of Clinical Radiology Graduate School Of Medical Sciences Kyushu University
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Saito Kazuhiro
Department Of Radiology Tokyo Medical University
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Saito Kazuhiro
Department Of Chemistry Faculty Of Science Yamagata University
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ABE Kimihiko
Department of Radiology, Tokyo Medical University
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