Phycocyanin Enhances Secretary IgA Antibody Response and Suppresses Allergic IgE Antibody Response in Mice Immunized with Antigen-Entrapped Biodegradable Microparticles
スポンサーリンク
概要
- 論文の詳細を見る
In the present study, we have investigated the effects of phycocyanin, a biliprotein of Spirulina platensis, on mucosal and systemic immune responses and allergic inflammation in C3H/HeN and BALB/cA mice. To induce the antigen-specific antibodies in the peripheral lymphoid tissues such as Peyer's patches and mesenteric lymph nodes, biodegradable ovalbumin-entrapped poly (DL-lactide-co-glycolide) particles were used as an antigen. Two weeks after the onset of phycocyanin ingestion, mice were immunized with an aqueous ovalbumin (OVA) solution. Starting at one week after the primary immunization, the mice were subjected to oral immunization with the biodegradable OVA micropartides twice a week. IgA, IgE and IgG 1 antibodies were determined by ELISA. The OVA microparticles of 4-μm diameter successfully induced antigen-specific antibodies. In the mice that received phycocyanin treatment for 6 wk, a marked increase in the antigen-specific, as well as the total, IgA antibody level was observed in the Peyer's patches, mesenteric lymph nodes and intestinal mucosa as well as in the spleen cells. Both antigen-specific IgGl and IgE antibody levels in the serum were suppressed by ingestion of phycocyanin for 8 wk. However, inflammation of the small intestine, monitored as vascular permeability by the Evans blue-leaking method was reduced by phycocyanin at 6 wk, which preceded the suppression of antigen-specific IgGl and IgE antibody production by 2 wk. These results suggest that phycocyanin enhances biological defense activity against infectious diseases through sustaining functions of the mucosal immune system and reduces allergic inflammation by the suppression of antigen-specific IgE antibody.
- 日本ビタミン学会の論文
著者
-
NAGAI Takayuki
Kitasato Institute for Life Sciences & Graduate School of Infection Control Sciences, Kitasato Unive
-
HAYASHI Osamu
Department of Ophthalmology, Shiga University of Medical Science
-
YAMADA HARUKI
Kitasato Institute for Life Sciences, Kitasato University
-
Yamada Haruki
Oriental Medicine Research Center Of The Kitasato Institute
-
Hayashi Osamu
Department Of Ophthalmology Shiga University Of Medical Science
-
Nagai Takayuki
Kitasato Institute For Life Sciences Kitasato University
-
Hayashi Osamu
Department Of Health And Nutrition Kagawa Nutrition University
-
NEMOTO-KAWAMURA Chinami
Department of Health and Nutrition, Kagawa Nutrition University
-
HIRAHASHI Tomohiro
Biochemical Division, Dainippon Ink & Chemicals Inc.
-
KATOH Toshimitsu
Biochemical Division, Dainippon Ink & Chemicals Inc.
-
Yamada Haruki
Kitasato Institute For Life Sciences & Graduate School Of Infection Control Sciences Kitasato Un
-
Katoh Toshimitsu
Biochemical Division Dainippon Ink & Chemicals Inc.
-
Hirahashi Tomohiro
Biochemical Division Dainippon Ink & Chemicals Inc.
-
Nemoto-kawamura Chinami
Department Of Health And Nutrition Kagawa Nutrition University
-
Yamada Haruki
Kitasato Institute For Life Sciences Kitasato University
関連論文
- Antidepressant-like effect of a Kampo (Japanese herbal) medicine, kososan, against the interferon-α-induced depressive-like model mice
- Pharmacological analysis for the optimal combination ratio of Shakuyaku and Kanzo in Shakuyakukanzoto
- A Muscle Transposition Procedure for Abducens Palsy, in Which the Halves of the Vertical Rectus Muscle Bellies Are Sutured Onto the Sclera
- VOLUME MEASUREMENT OF HORIZONTAL EXTRAOCULAR MUSCLES WITH MAGNETIC RESONANCE IMAGING
- In Vitro and in Vivo Antimalarial Activities of a Non-glycosidic 18-Membered Macrolide Antibiotic, Borrelidin, against Drug-resistant Strains of Plasmodia
- Toxicity and Oxidative Stress Induced by Organic Arsenical Diphenylarsinic Acid and Inorganic Arsenicals and Their Effects on Spatial Learning Ability in Mice
- In Vitro and in Vivo Antitrypanosomal Activitiy of Two Microbial Metabolites, KS-505a and Alazopeptin
- Syntheses of Model Compounds Related to an Antigenic Epitope in Pectic Polysaccharides from Bupleurum falcatum L. (II)
- A Possible Mechanism Underlying an Antidepressive-Like Effect of Kososan, a Kampo Medicine, via the Hypothalamic Orexinergic System in the Stress-Induced Depression-Like Model Mice
- Rosmarinic Acid from Perillae Herba Produces an Antidepressant-Like Effect in Mice through Cell Proliferation in the Hippocampus(Pharmacology)
- A Simple Muscle Transposition Procedure for Abducens Palsy Without Tenotomy or Splitting Muscles
- Enhancement of in Vivo Anti-influenza Virus Activity of 5,7,4'-Trihydroxy-8-methoxyflavone by Drug Delivery System Using Hydroxypropyl Cellulose
- Antiplasmodial and antitrypanosomal activity of plants from the Kingdom of Saudi Arabia
- Selective and Potent in Vitro Antitrypanosomal Activities of Ten Microbial Metabolites
- In vitro antimalarial activity of prenylated flavonoids from Erythrina fusca
- In Vitro and In Vivo Antimalarial Activities of a Carbohydrate Antibiotic, Prumycin, against Drug-resistant Strains of Plasmodia
- Chemical Constituents of Erythrina suberosa
- In Vitro Antimalarial Activities of the Microbial Metabolites
- In Vitro In Vivo Antimalarial Activities of the Monoglycoside Polyether Antibiotic, K-41 against Drug Resistant Strains of Plasmodia
- ANTI-INFLUENZA VIRUS ACTIVITY OF PLANT FLAVONOIDS HAVING INHIBITORY ACTIVITY AGAINST INFLUENZA VIRUS SIALIDASE
- Investigation of Reasons for Discontinuance of Kampo Medicines (Japanese traditional herbal medicines) and Improvement of Continuance through Better Instructions to Patients
- Phycocyanin Enhances Secretary IgA Antibody Response and Suppresses Allergic IgE Antibody Response in Mice Immunized with Antigen-Entrapped Biodegradable Microparticles
- Class Specific Influence of Dietary Spirulina platensis on Antibody Production in Mice
- INDIVIDUAL DIFFERENCES BETWEEN LEADERS IN A SIMULATED FIRE
- Synthesis of Piperazines and Thiomorpholines by Ozonolysis of Cyclic Olefins and Reductive N-Alkylation(Organic Chemistry)
- An Asymmetric Synthesis of 2-Substituted Piperidines through Ozonolysis of Cyclopentenes and Reductive Aminocyclization(Organic Chemistry)
- Butyrate Induces Necrotic Cell Death in Murine Colonic Epithelial Cell MCE301(Pharmacology)
- CHEMICAL STRUCTURES AND MODE OF ACTIONS OF ANTICOMPLEMENTARY POLYSACCHARIDES FROM CHINESE HERBS
- STUDIES ON POLYSACCHARIDES FROM ANGELICA ACUTILOBA. V. MOLECULAR AGGREGATION AND ANTI-COMPLEMENTARY ACTIVITY OF ARABINOGALACTAN FROM ANGELICA ACUTILOBA
- Effects of Clinacanthus siamensis leaf extract on influenza virus infection
- Chemical Constituents of Erythrina suberosa
- Class Specific Influence of Dietary Spirulina platensis on Antibody Production in Mice
- Panowamycins A and B, new antitrypanosomal isochromans produced by Streptomyces sp. K07-0010
- In vitro antitrypanosomal activity of five low-MW antibiotics
- In vitro and in vivo anti-Trypanosoma brucei activities of phenazinomycin and related compounds
- Promising lead compounds for novel antiprotozoals
- Sinefungin VA and dehydrosinefungin V, new antitrypanosomal antibiotics produced by Streptomyces sp. K05-0178
- In vitro antitrypanosomal activity of 12 low-molecular-weight antibiotics and observations of structure/activity relationships
- In vitro and in vivo antiprotozoal activities of bispolides and their derivatives
- Pyrenocine I, a new pyrenocine analog produced by Paecilomyces sp. FKI-3573
- Enhancement of Antibody Production in Mice by Dietary Spirulina platensis.