Synthesis of Piperazines and Thiomorpholines by Ozonolysis of Cyclic Olefins and Reductive N-Alkylation(Organic Chemistry)
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概要
- 論文の詳細を見る
Ozonized 1-trifluoroacetyl-3-pyrroline (2a) and 3-sulfolene (6) were reduced with sodium cyanoborohydride (1) to afford the dialdehyde, which reacted in situ with the primary amines 3a〜d in the presence of 1 to give the piperazines 4a〜d (21〜60%) and the dioxothiomorpholines 7a〜d (26〜76%). Reduction of 7a and 7c with diisobutylaluminum hydride yielded the thiomorpholines 8a and 8c, respectively. On the other hand, the 9-membered azacrown ethers 10 and 11 were obtained when N,N´-dibenzylethylenediamine (9) was employed. The dioxothiomorpholine derivatives 13 of amino acids were also prepared by the same treatment.
- 社団法人日本農芸化学会の論文
- 1987-02-23
著者
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Hamada Masayuki
Department of Intern. Med. Mie Univ. School of Med.
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HAYASHI Osamu
Department of Ophthalmology, Shiga University of Medical Science
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Yamamoto Y
Osaka City Univ. Osaka Jpn
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HAMADA Masayuki
ULSI Device Development Laboratories NEC Corporation
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Hayashi Osamu
Department Of Ophthalmology Shiga University Of Medical Science
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Hayashi Osamu
International Reagent Corporation
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Hamada M
Ulsi Device Development Laboratories Nec Corporation
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Hamada Masayuki
Department Of Agricultural Chemistry And Faculty Of Agriculture Kinki University
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Hayashi Osamu
Department Of Health And Nutrition Kagawa Nutrition University
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KAWAGUCHI Mamoru
International Reagent Corporation
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KANAMOTO Masahiro
Department of Agricultural Chemistry, Kinki University
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YAMAMOTO Yukio
Institute for Chemical Research, Kyoto University
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Kanamoto Masahiro
Department Of Agricultural Chemistry Kinki University
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Kawaguchi M
Hosei Univ. Jpn
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