Suppression of Proliferation of Poliovirus and Porcine Parvovirus by Novel Phenoxazines, 2-Amino-4,4α-dihydro-4α-7-dimethyl-3H-phenoxazine-3-one and 3-Amino-1,4α-dihydro-4α-8-dimethyl-2H-phenoxazine-2-one(Pharmacology)

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概要

• 論文の詳細を見る

• The present study aimed at investigating the antiviral effects of 2-amino-4,4α-dihydro-4α-7-dimethyl-3H-phenoxazine-3-one (Phx-1) and 3-amino-1,4α-dihydro-4α-8-dimethyl-2H-phenoxazine-2-one (Phx-2) on 6 representative viruses : poliovirus, porcine parvovirus, simian virus 40 (SV-40), herpes simplex virus-1 (HSV-1), Sindbis virus, and vesicular stomatitis virus (VSV). Phx-1 and Phx-2 suppressed the proliferation of poliovirus in Vero cells and that of porcine parvovirus in ESK cells at concentrations between 0.25μg/ml and 2μg/ml, when the cells were treated with Phx-1 and Phx-2 for 1 h and then inoculated with these viruses. The proliferation of the other viruses, SV-40, HSV-1, Sindbis virus, and VSV, in the host cells was not influenced by Phx-1 or Phx-2 at concentrations less than 20μg/ml. The results suggest that Phx-1 and Phx-2 may be useful to prevent the proliferation of poliovirus and porcine parvovirus infection and may contribute to developing new antiviral drugs in future.

• 社団法人日本薬学会の論文
• 2005-05-01

著者

• Tomoda Akio

  Department of Biochemistry and Intractable Immune System Disease Research Center, Tokyo Medical Univ

• Yamaguchi Teruhide

  Division of Biological Chemistry and Biologicals, National Institute of Health Sciences

• IWATA Akiko

  Division of Functional Diagnostic Science, Graduate School of Medicine, Osaka University

• SATO KOUEI

  The Institute of Saitama Red Cross Center

• Tomoda A

  Tokyo Medical Univ.

• Tomoda Akio

  Department Of Biochemistry And Intractable Tokyo Medical University

• Tomoda Akio

  Department Of Biochemistry And Intractable Immune System Disease Research Center Tokyo Medical Unive

• Tomoda Akio

  Graduate School Of Medical And Dental Sciences Kagoshima University

• YOSHITAKE Noriko

  Third Department of Internal Medicine, Tokyo Medical University

• Yamaguchi Teruhide

  Division Of Biological Chemistry And Biologicals National Institute Of Health Sciences

• Tomoda Akio

  Tokyo Medical Univ.

• Iwata Akiko

  Division Of Cellular And Gene Therapy Products National Institute Of Health Sciences

• Tomoda Akio

  Department Of Biochemistry And Intractable Immune System Disease Research Center Tokyo Medical Unive

• Yoshitake Noriko

  Third Department Of Internal Medicine Tokyo Medical University

• Yamaguchi Teruhide

  Division of Cellular and Gene Therapy Products, National Institute of Health, Sciences

• Yamaguchi Teruhide

  Division of Biological Chemistry & Biologicals, National Institute of Health Sciences

• Sato Kouei

  The Institute of Saitama Red Cross Cente

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