The Phenoxazine Derivative Phx-1 Suppresses IgE-Mediated Degranulation in Rat Basophilic Leukemia RBL-2H3 Cells

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概要

• 論文の詳細を見る

• Antigen-induced aggregation of the high affinity IgE receptor (FcεRI) on mast cells induces degranulation to release chemical mediators, leading to acute allergic inflammation. We have demonstrated that the treatment of rat mast cells, RBL-2H3, with a phenoxazine derivative Phx-1 (2-amino-4,4α-dihydro-4α,7-dimethyl-3H-phenoxazine-3-one) suppresses the antigen-induced degranulation. Biochemical analysis reveals that the complementary signaling pathway through Gab2 and Akt is inhibited by this compound in mast cells. These findings suggest that phenoxazine derivatives may have a therapeutic potential for allergic diseases by inhibiting mast cell degranulation.

• 社団法人 日本薬理学会の論文
• 2004-03-01

著者

• Tomoda Akio

  Department of Biochemistry and Intractable Immune System Disease Research Center, Tokyo Medical Univ

• 榎木 英介

  神戸大学医学部附属病院病理診断科

• SADA Kiyonao

  Division of Microbiology, Kobe University Graduate School of Medicine

• Sada Kiyonao

  Division Of Proteomics Department Of Genome Sciences Kobe University Graduate School Of Medicine

• Sada Kiyonao

  Division Of Microbiology Kobe University Graduate School Of Medicine

• Miah S.

  Division Of Proteomics Department Of Genome Sciences Kobe University Graduate School Of Medicine

• Tomoda Akio

  Department Of Biochemistry Tokyo Medical University

• Tomoda Akio

  Department Of Biochemistry And Intractable Immune System Disease Research Center Tokyo Medical Unive

• ENOKI Eisuke

  Division of Proteomics, Department of Genome Sciences, Kobe University Graduate School of Medicine

• QU Xiujuan

  Division of Proteomics, Department of Genome Sciences, Kobe University Graduate School of Medicine

• KYO Shinkou

  Division of Proteomics, Department of Genome Sciences, Kobe University Graduate School of Medicine

• HATANI Tomoko

  Division of Proteomics, Department of Genome Sciences, Kobe University Graduate School of Medicine

• YAMAMURA Hirohei

  Division of Proteomics, Department of Genome Sciences, Kobe University Graduate School of Medicine

• Qu Xiujuan

  Division Of Proteomics Department Of Genome Sciences Kobe University Graduate School Of Medicine

• Kyo S

  Division Of Proteomics Department Of Genome Sciences Kobe University Graduate School Of Medicine

• Enoki Eisuke

  Department Of Pathology Kobe University Graduate School Of Medicine

• Enoki Eisuke

  Division Of Proteomics Department Of Genome Sciences Kobe University Graduate School Of Medicine

• Enoki Eisuke

  Department Of Diagnostic Pathology Kobe University Graduate School Of Medicine

• Hatani Tomoko

  Division Of Proteomics Department Of Genome Sciences Kobe University Graduate School Of Medicine

• 榎木 英介

  赤穂市民病院病理部

• Yamamura Hirohei

  Division Of Proteomics Department Of Genome Sciences Kobe University Graduate School Of Medicine

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