2-Aminophenoxazine-3-one Suppresses the Growth of Mouse Malignant Melanoma B16 Cells Transplanted into C57BL/6Cr Slc Mice(Pharmacology)
スポンサーリンク
概要
- 論文の詳細を見る
Since phenoxazine is an essential structure of actinomycin D, which exerts a strong anticancer effect, we examined the anticancer effect of 2-aminophenoxazine-3-one (Phx-3) on mouse malignant melanoma B16 cells in vitro and in vivo. Phx-3 inhibited proliferation of the B16 cells in a dose-dependent manner in vitro. We furthermore studied the in vivo effects of Phx-3 on mouse malignant melanoma B16 cells transplanted in female C57BL/6Cr Slc mice. Treatment with Phx-3 (0.5mg/kg) completely suppressed the growth of mouse malignant melanoma B16 cells transplanted in mice as compared with the control group. Phx-3 was found to exert few adverse effects, in terms of bodyweight loss, changes in serum levels of blood biochemical parameters such as aspartate transaminase (AST), alanine transaminase (ALT), blood urea nitrogen (BUN) and creatinine, dysfunction of the liver and the kidney examined by pathological methods, piloerection and wasting, when mice were treated with a dose of 0.5mg/kg. These results suggest that Phx-3 may be used to treat patients affected by malignant melanoma in future.
- 社団法人日本薬学会の論文
- 2006-11-01
著者
-
Tomoda Akio
Department of Biochemistry and Intractable Immune System Disease Research Center, Tokyo Medical Univ
-
ENDO Takahiko
Department of Physics,Faculty of Science and Technology,Keio University
-
Tomoda Akio
Dep. Of Biochemistry Tokyo Medical Univ. Jpn
-
Tomoda Akio
Department Of Biochemistry And Intractable Tokyo Medical University
-
Tomoda Akio
Department Of Biochemistry And Intractable Immune System Disease Research Center Tokyo Medical Unive
-
SHIRATO Ken
Laboratory of Physiological Sciences, Faculty of Human Sciences, Waseda University
-
KUROSAKI Kunihiko
Department of Legal Medicine, School of Medicine, Toho University
-
MIYANO-KUROSAKI Naoko
Department of Life and Environmental Sciences, Faculty of Engineering, Chiba Institute of Technology
-
HAYASHI Michiko
Department of Legal Medicine, School of Medicine, Toho University
-
TAKAKU Hiroshi
Department of Life and Environmental Sciences, Faculty of Engineering, Chiba Institute of Technology
-
HAYAFUNE Masaaki
Department of Life and Environmental Sciences, Faculty of Engineering, Chiba Institute of Technology
-
KASUGA Teruhiko
4th Department of Surgery, Tokyo Medical University
-
Endo Takahiko
Department Of Fermentation Tachnology Faculty Of Engineering Hiroshima University
-
Kurosaki Kunihiko
Department Of Forensic Medicine Tokyo Medical University
-
Shirato Ken
Laboratory Of Physiological Sciences Faculty Of Human Sciences Waseda University
-
Shirato Ken
Laboratory Of Physiological Sciences Graduate School Of Human Sciences Waseda University
-
Takaku Hiroshi
Department Of Life And Environmental Science Chiba Institute Of Technology
-
Kasuga Teruhiko
4th Department Of Surgery Tokyo Medical University
-
Hayashi Michiko
Department Of Legal Medicine School Of Medicine Toho University
-
Hayafune Masaaki
Department Of Life And Environmental Sciences Faculty Of Engineering Chiba Institute Of Technology
-
Takaku Hiroshi
Department Of Industrial Chemistry Chiba Institute Of Technology
-
Hayashi Michiko
Department Of Anesthesiology And Critical Care Medicine Yokohama City University Graduate School Of
-
Kurosaki Kunihiko
Department Of Legal Medicine School Of Medicine Toho University
-
Takaku Hiroshi
Department of Chemistry, Chiba Institute of Technology
関連論文
- Phenoxazine Derivatives Suppress the Infections Caused by Herpes Simplex Virus Type-1 and Herpes Simplex Virus Type-2 Intravaginally Inoculated Into Mice
- 2-Aminophenoxazine-3-one Prevents Pulmonary Metastasis of Mouse B16 Melanoma Cells in Mice
- Long-Time Spin Relaxation in Zero-Field
- Significance of Post-Exercise Increment of Urinary Bicarbonate and pH in Subjects Loaded with Submaximal Cycling Exercise
- Marked Increase in Urinary Bicarbonate and pH Caused by Heavy Muscular Exercise with Dynamic Knee Extension
- Circadian Changes in Urinary Bicarbonate, Nitric Oxide Metabolites and pH in Female Player during Handball Camp Involved in an Exercise, Rest and Sleep Cycle
- Antiviral Activity of 2-Amino-4, 4α-Dihydro-4α-7-Dimethyl-3H-Phenoxazine-3-One on Poliovirus
- Anticancer Effects of Phenoxazine Derivatives Revealed by Inhibition of Cell Growth and Viability, Disregulation of Cell Cycle, and Apoptosis Induction in HTLV-1-Positive Leukemia Cells
- Phenoxazine Derivatives Inactivate Human Cytomegalovirus, Herpes Simplex Virus-1, and Herpes Simplex Virus-2 In Vitro
- Apoptosis Induction Preceded by Mitochondrial Depolarization in Multiple Myeloma Cell Line U266 by 2-Aminophenoxazine-3-one(Medicinal Chemistry)
- β_2-Agonist Clenbuterol Induced Changes in the Distribution of White Blood Cells in Rats
- Phenoxazine Derivatives 2-Amino-4,4α-dihydro-4α-phenoxazine-3-one and 2-Aminophenoxazine-3-one-Induced Apoptosis through a Caspase-Independent Mechanism in Human Neuroblastoma Cell Line NB-1 Cells(Medicinal Chemistry)
- Rapid and Large-scale Isolation of Microsomal Fraction of Mouse Liver by Lyophilization and Low Speed Centrifugation
- Mechanisms of the inhibitory effects of a phenoxazine compound, 2-amino-4,4α-dihydro-4α-7-dimethyl-3H-phenoxazine-3-one, on the contraction of the smooth muscle of the guinea pig taenia cecum
- A Phenoxazine Compound, 2-Amino-4, 4α-dihydro-4α-7-dimethyl-3H-phenoxazine-3-one Reverses the Phenylephrine or High-K^+ Induced Contraction of Smooth Muscles in Rat Aorta and Guinea Pig Tenia Cecum(Pharmacology)
- 2-Aminophenoxazine-3-one Suppresses the Growth of Mouse Malignant Melanoma B16 Cells Transplanted into C57BL/6Cr Slc Mice(Pharmacology)
- Metabolism of Pyrogallol to Purpurogallin by Human Erythrocytic Hemoglobin
- Effects of Novel Phenoxazine Compounds, 2-Amino-4, 4α-Dihydro-4α, 7-Dimethyl-3H-Phenoxazine-3-One and 3-Amino-1, 4α-Dihydro-4α, 8-Dimethyl-2H-Phenoxazine-2-One on Proliferation of Phytohemagglutinin- or Anti-Human IgM-Activated Human Peripheral Blood Mono
- Oscillatory Oxido-Reductive Reaction of Intracellular Hemoglobin in Human Erythrocyte Incubated with o-Aminophenol
- Multi - Effective Properties of Homogentisic Acid Revealed in Reactions With Human Hemoglobin and Human Erythrocytic Hemoglobin
- The Phenoxazine Derivative Phx-1 Suppresses IgE-Mediated Degranulation in Rat Basophilic Leukemia RBL-2H3 Cells
- Suppression of Proliferation of Poliovirus and Porcine Parvovirus by Novel Phenoxazines, 2-Amino-4,4α-dihydro-4α-7-dimethyl-3H-phenoxazine-3-one and 3-Amino-1,4α-dihydro-4α-8-dimethyl-2H-phenoxazine-2-one(Pharmacology)
- Significance of Rises in Urinary Bicarbonate Contents and pH Related with Increased Atmospheric Carbon Dioxide in Tokyo
- Changes in Nitric Oxide Generated by the Oxidation of Oxymyoglobin by Nitrite
- Nitric Oxide-Independent cGMP Efflux in the Striatum of Rats Exposed to Carbon Monoxide as Determined by Microdialysis
- Sleeping environments as risk factors of sudden infant death syndrome in Japan
- Fed-Batch Culture with a Modified DO-Stat Method
- A RELATIONSHIP BETWEEN ELECTROCHEMICAL REDUCTION POTENTIAL AND THE ENZYMATIC REDUCTION OF NITRATED NAPHTHALENES BY MICROSOMES OR CYTOSOL FROM RAT LIVER
- Purification, Molecular Cloning, and Genomic Organization of Human Brain Long-Chain Acyl-CoA Hydrolase
- Autonomous Proliferation of HTLV^-CD4^+ T Cell Clones Derived from Human T Cell Leukemia Virus Type I (HTLV-I)-Associated Myelopathy Patients
- Interaction Analysis between tmRNA and SmpB from Thermus thermophilus
- Effect of Helicobacter pylori on DNA synthesis of human epithelial cells
- Phenoxazine Compounds Produced by the Reactions with Bovine Hemoglobin Show Antimicrobial Activity Against Non-tuberculosis Mycobacteria
- Identification of Sialyltransferases of Streptococcus agalactiae
- Molecular Characterization of a Novel β1, 3-Galactosyltransferase for Capsular Polysaccharide Synthesis by Streptococcus agalactiae Type Ib^1
- P-29 Cadmium Content and Expression of Metallothionein m-RNA in CdCl_2-Exposed Rat Liver and Kidney
- The Comparative Effects of 1, 2-Dibromo Compounds on the Liver and Kidney of Rats.
- The CETP can recognize to marginal zone B lymphocyte
- P-34 Expression of intracellular domain of OX40(Part II)
- Effect of Ethyl Icosapentaenoate(EPA) on the Concentration of Tumor Necrosis Factor(TNF) and Interleukin-1(IL-1) in the Carotid Artery of Cuffsheathed Rabbit Models
- Solution RNA Structures of the HIV-1 Dimerization Initiation Site in the Kissing-Loop and Extended-Duplex Dimers
- Role of the Zinc Fingers of HIV-1 Nucleocapsid Protein in Maturation of Genomic RNA
- NMR Analysis of Intra-and Inter-Molecular Stems in the Dimerzation Initiation Site of the HIV-1 Genome
- P-28 Experimental Studies on Defenses Mechanisms of the Body Against Flunitrazepam Accumulation
- Recognition of a Bulged RNA by Peptides Derived from the Influenza NS1 Protein
- RNA Interference Targeted to the Conserved Dimerization Initiation Site (DIS) of HIV-1 Restricts Virus Escape Mutation
- An Easy Cell-Free Protein Synthesis System Dependent on the Addition of Crude Escherichia coli tRNA^1
- 2-Aminophenoxazine-3-one and 2-amino-4,4α-dihydro-4α,7-dimethyl-3H-phenoxazine-3-one cause cellular apoptosis by reducing higher intracellular pH in cancer cells
- Acute Effects of Dihydrocapsaicin and Capsaicin on the Distribution of White Blood Cells in Rats
- Zinc-Deficiency Induced Changes in the Distribution of Rat White Blood Cells
- Dietary zinc-deficiency and its recovery responses in rat liver cytosolic alcohol dehydrogenase activities
- Single administration effects of ethanol on the distribution of white blood cells in rats
- Synthesized glucocorticoid, dexamethasone regulates the expressions of β2-adrenoceptor and glucocorticoid receptor mRNAs but not proteins in slow-twitch soleus muscle of rats
- Nucleoside Phosphite, O-Bis(1, 1, 1, 3, 3, 3-hexafluoro-2-propyl) Deoxyribonucleosid-3' -yl Phosphites. A Versatile Synthetic Intermediate for Phosphonate Modified Nucleotide and Oligonucleotide Synthesis
- Dietary zinc-deficiency and its recovery responses in the thermogenesis of rats
- Single administration effects of ethanol on the distribution of white blood cells in rats
- Intrathecally administered Sema3A protein attenuates neuropathic pain behavior in rats with chronic constriction injury of the sciatic nerve
- Selectively Induced Apoptosis in Human Neutrophils in the Presence of Oxidative Phenoxazines, 2-Amino-4,4α-dihydryo-4α-7H-phenoxazine-3-one and 2-Aminophenoxazine-3-one, Preceded by Decrease of Intracellular pH, Depolarization of the Mitochondria, and Inh
- Dietary zinc-deficiency and its recovery responses in the thermogenesis of rats
- Synthesized glucocorticoid, dexamethasone regulates the expressions of β_2-adrenoceptor and glucocorticoid receptor mRNAs but not proteins in slow-twitch soleus muscle of rats
- Phenoxazine Derivatives Suppress the Infections Caused by Herpes Simplex Virus Type-1 and Herpes Simplex Virus Type-2 Intravaginally Inoculated Into Mice
- 2-Aminophenoxazine-3-one Prevents Pulmonary Metastasis of Mouse B16 Melanoma Cells in Mice
- Selectively Induced Apoptosis in Human Neutrophils in the Presence of Oxidative Phenoxazines, 2-Amino-4,4α-dihydryo-4α-7H-phenoxazine-3-one and 2-Aminophenoxazine-3-one, Preceded by Decrease of Intracellular pH, Depolarization of the Mitochondria, and Inh
- Age-related effects of fasting on ketone body production during lipolysis in rats
- Effect of exercise on HIF-1 and VEGF signaling
- Diallyl Disulfide Reduced Dose-Dependently the Number of Lymphocyte Subsets and Monocytes in Rats
- Effects of exercise on the hexosamine biosynthetic pathway and glycosylation
- Effects of β2-agonists and exercise on β2-adrenergic receptor signaling in skeletal muscles
- Different Rcoevery Responses from Dietary Zinc-Deficiency in the Distribution of Rat Granulocytes
- Cyclosporin A Inhibits the Propagation of Influenza Virus by Interfering with a Late Event in the Virus Life Cycle
- A Study on Phosphorylation by Means of 8-Quinolyl Phosphates
- β2-Agonist Clenbuterol Suppresses Bacterial Phagocytosis of Splenic Macrophages Expressing High Levels of Macrophage Receptor with Collagenous Structure
- Folate-deficiency induced cell-specific changes in the distribution of lymphocytes and granulocytes in rats
- Purification, Molecular Cloning, and Genomic Organization of Human Brain Long-Chain Acyl-CoA Hydrolase.
- Effects of β_2-agonists and exercise on β_2-adrenergic receptor signaling in skeletal muscles
- Intracellular β_2-adrenergic receptor signaling specificity in mouse skeletal muscle in response to single-dose β_2-agonist clenbuterol treatment and acute exercise