A Phenoxazine Compound, 2-Amino-4, 4α-dihydro-4α-7-dimethyl-3H-phenoxazine-3-one Reverses the Phenylephrine or High-K^+ Induced Contraction of Smooth Muscles in Rat Aorta and Guinea Pig Tenia Cecum(Pharmacology)

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概要

• 論文の詳細を見る

• 2-Amino-4, 4α-dihydro-4α-7-dimethyl-3H-phenoxazine-3-one (Phx-1) reversed concentration dependently the contraction of both rat aorta and guinea pig tenia cecum induced by phenylephrine or high-K^+. Since Phx-1 suppresses the responses of human mononuclear cells to phytohemagglutinin, (Akazawa et al. Tohoku J. Exp. Med., 196, 185-192, 2002), Phx-1 may be useful for developing new vasorelaxing agents with immunosuppressive action.

• 社団法人日本薬学会の論文
• 2005-08-01

著者

• Tomoda Akio

  Department of Biochemistry and Intractable Immune System Disease Research Center, Tokyo Medical Univ

• WATANABE Masaru

  Department of Physics, Aoyama-Gakuin University

• Konishi Masato

  Department Of Physiology Tokyo Medical University

• Konishi Masato

  Department Of Physiology The Jikei University School Of Medicine

• Tomoda Akio

  Department Of Biochemistry And Intractable Immune System Disease Research Center Tokyo Medical Unive

• Tomoda Akio

  Graduate School Of Medical And Dental Sciences Kagoshima University

• MUSHA Saifuding

  Department of Physiology, Tokyo Medical University

• ISHIDA Yukisato

  Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine

• KATO Seiko

  Third Department of Internal Medicine, Tokyo Medical University

• Watanabe Masaru

  Department Of Cosmosciences Hokkaido University

• Watanabe Masaru

  Department Of Physiology Tokyo Medical University

• Tomoda Akio

  Tokyo Medical Univ.

• Kato Seiko

  Third Department Of Internal Medicine Tokyo Medical University

• Ishida Yukisato

  Department Of Molecular And Cellular Physiology University Of Cincinnati College Of Medicine

• Musha Saifuding

  Department Of Physiology Tokyo Medical University

• Tomoda Akio

  Department Of Biochemistry And Intractable Immune System Disease Research Center Tokyo Medical Unive

• Watanabe Masaru

  Department Of Chemical Engineering Tohoku University

• Konishi Masato

  Department Of Cell Physiology The Jikei University School Of Medicine

• WATANABE Masaru

  Department of Physiology, Tokyo Medical University

• ISHIDA Yukisato

  Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo

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