In Vitro Antibacterial Activity of Phx-3 against Helicobacter pylori
スポンサーリンク
概要
- 論文の詳細を見る
Phx-3, one of the phenoxazine derivatives, is reported to have inhibitory effect on Mycobacterium species and Chlamydia pneumoniae but not Escherichia coli, Salmonella Typhimurium, Pseudomonas aeruginosa, Staphylococcus aureus, Listeria monocytogenes. The bactericidal activities of Phx-3 against Helicobacter pylori strains have not been assessed. Then, we measured minimum inhibitory concentration of Phx-3 for Helicobacter strains and assessed the morphological and biochemical effects of Phx-3 on H. pylori. In present study, it has shown that H. pylori strains including clarithromycin resistant strain and Helicobacter musterae were killed effectively by the treatment with Phx-3. Furthermore, severe morphological changes such as membrane blebbing and formation of hollows in H. pylori were detected. In addition, induction of heat shock protein 60 was observed. Taken together, Phx-3 has antibacterial activity against Helicobacter pylori.
- 日本薬学会の論文
著者
-
Osaki T
Department Of Infectious Diseases Kyorin University School Of Medicine
-
Osaki Takako
Dep. Of Infectious Diseases Div. Of Medical Microbiology Kyorin Univ. School Of Medicine
-
Hotta T
Division Of Hematology And Oncology Department Of Medicine Tokai University School Of Medicine
-
KAMIYA Shigeru
Department of Infectios Diseases, Kyorin University School of Medicine
-
Hanawa Tomoko
Department of Infectious Diseases, Division of Medical Microbiology, Kyorin University, School of Me
-
Osaki Takako
Department of Infectious Diseases, Division of Medical Microbiology, Kyorin University, School of Me
-
Manzoku Taki
Miyarisan Pharmaceutical Co., Ltd.
-
Fukuda Minoru
Laboratory for Electron Microscopy, Kyorin University, School of Medicine
-
Kawakami Hayato
Second Department of Anatomy, Department of Biochemistry, Kyorin University, School of Medicine
-
Tomoda Akio
Tokyo Medical University
-
Kawakami Hayato
Second Dep. Of Anatomy Dep. Of Biochemistry Kyorin Univ. School Of Medicine
-
Tomoda Akio
Tokyo Medical Univ.
-
Kamiya Shigeru
Department Of Infectios Diseases Kyorin University School Of Medicine
-
Hanawa Tomoko
Department Of Infectious Diseases Kyorin University School Of Medicine
-
Fukuda Minoru
Laboratory For Electron Microscopy Kyoimn University School Of Medicine
-
Kamiya Shigeru
Department of Fundamental Nursing, Faculty of Medicine, University of the Ryukyus
-
Kamiya Shigeru
Department of Infectious Diseases, Division of Medical Microbiology, Kyorin University, School of Medicine
-
Osaki Takako
Department of Infectious Diseases, Division of Medical Microbiology, Kyorin University, School of Medicine
-
Hanawa Tomoko
Department of Infectious Diseases, Division of Medical Microbiology, Kyorin University, School of Medicine
-
HANAWA Tomoko
Department of Biochemistry, Hyogo College of Medicine
関連論文
- Ciliates rapidly enhance the frequency of conjugation between Escherichia coli strains through bacterial accumulation in vesicles
- Expression analysis of activin receptor interacting protein (ARIP) in Xenopus
- Cloning and characterization of Xenopus Activin receptor interacting protein(xARIP)(Developmental Biology)(Proceeding of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
- Antiviral Activity of 2-Amino-4, 4α-Dihydro-4α-7-Dimethyl-3H-Phenoxazine-3-One on Poliovirus
- Mechanisms of the inhibitory effects of a phenoxazine compound, 2-amino-4,4α-dihydro-4α-7-dimethyl-3H-phenoxazine-3-one, on the contraction of the smooth muscle of the guinea pig taenia cecum
- A Phenoxazine Compound, 2-Amino-4, 4α-dihydro-4α-7-dimethyl-3H-phenoxazine-3-one Reverses the Phenylephrine or High-K^+ Induced Contraction of Smooth Muscles in Rat Aorta and Guinea Pig Tenia Cecum(Pharmacology)
- Suppression of Proliferation of Poliovirus and Porcine Parvovirus by Novel Phenoxazines, 2-Amino-4,4α-dihydro-4α-7-dimethyl-3H-phenoxazine-3-one and 3-Amino-1,4α-dihydro-4α-8-dimethyl-2H-phenoxazine-2-one(Pharmacology)
- P3-27 Localization of NBC-1 isoforms in rat and human kidneys
- MS2-4 Morphometrical evaluation of androgen action in testis and prostate
- Association between Helicobacter bilis in Bile and Biliary Tract Malignancies : H. bilis in Bile from Japanese and Thai Patients with Benign and Malignant Diseases in the Biliary Tract
- Myosin Light Chain Phosphorylation is Correlated with Cold-Induced Changes in Platelet Shape
- In Vitro Antibacterial Activity of Phx-3 against Helicobacter pylori
- Effect of Helicobacter pylori on DNA synthesis of human epithelial cells
- Immune response to heat shock protein of Helicobacter pylori- a candidate as a vaccine component
- Reactivity of monoclonal antibody to HSP60 homologue of Helicobacter pylori with human gastric epithelial cells and induction of IL-8 from these cells by purified H. Pylori HSP60
- Growth Inhibition of Helicobacter pylori by Monoclonal Antibody to Heat-Shock Protein 60
- Analysis of the Epitopes Recognized by Mouse Monoclonal Antibodies Directed to Yersinia enterocolitica Heat-Shock Protein 60
- Flow Cytometric Analysis Using Lipophilic Dye PKH-2 for Adhesion of Vibrio cholerae to Intestine 407 Cells
- Phenoxazine Compounds Produced by the Reactions with Bovine Hemoglobin Show Antimicrobial Activity Against Non-tuberculosis Mycobacteria
- Detection of Clostridium difficile Toxin A by Reversed Passive Latex Agglutination
- Efficacy of Clostridium butyricum preparation concomitantly with Helicobacter pylori eradication therapy in relation to changes in the intestinal microbiota
- Detection of Disialoganglioside in Rat Cerebellar Cortex by Light and Electron Microscopy
- P3-31 Distribution of the Long Form of Type XII Collagen during Chicken Corneal Formation
- Binding of Griffonia simplicifolia I-B_4 Lectin in the Substantia Gelatinosa of the Rat Spinal Cord
- P-47 Binding of Griffonia simplicifolia I-B_4 lectin in the substantia gelatinosa of rat spinal cord.
- Subcellular Localization of Galactosyltransferase Associated with Tumors in Endometrial and Ovarian Cancer Cells
- IIB-31 Histochemistry of Leprosy. Its Property to Improve Its Current Etiology(THE 46TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
- Effect of probiotic bacterial strains of Lactobacillus, Bifidobacterium, and Enterococcus on enteroaggregative Escherichia coli
- O-GlcNAc modification of nucleocytoplasmic proteins and diabetes
- Elevated Post-Translational Modification of Proteins by O-Linked N-Acetylglucosamine in Various Tissues of Diabetic Goto-Kakizaki Rats Accompanied by Diabetic Complications
- P-36-A Diabetic keratopathy and O-GlcNAc transferase in corneas of diabetic Goto-Kakizaki rat(THE JOINT MEETING OF THE 44TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY AND THE 35TH ANNUAL MEETING OF THE CLINICAL ELECTRON MICROS
- Phenotypic Alteration of Carbohydrate Antigens in Gynecological Malignancy
- Lectin-binding Patterns of the Normal and Malignant Endometrium.
- Mutual correlation between gastric flora and Helicobacter pylori in gastric mucosa of Mongolian gerbil (第43回 日本無菌生物ノートバイオロジー学会総会)
- Anti-CD20 Monoclonal Antibody as a New Treatment Modality for B-Cell Lymphoma
- P-57 Immunohistochemical study on cellular co-localization of estrogen and progesterone receptors, HSP90, and pS2 in breast cancer tissues
- Heat shock protein 60 (HSP60) immunoreactivity in gastric epithelium associated with Helicobacter pylori infection : A pitfall in immunohistochemically interpreting HSP60-mediated autoimmune responses
- B-1 Changes in Griffonia simplicifolia agglutinin- II and peanut agglutinin binding pattern in cell surface of mouse spermatogenic cells during postnatal development
- B-1 Changes in Griffonia simplicifolia agglutinin-II and peanut agglutinin binding pattern in cell surface of mouse spermatogenic cells during postnatal development
- Effect of the steroid receptor antagonist RU486 (mifepristone) on an IFNγ-induced persistent Chlamydophila pneumoniae infection model in epithelial HEp-2 cells
- Ciliates promote the transfer of the gene encoding the extended-spectrum -lactamase CTX-M-27 between Escherichia coli strains
- In vitro and in vivo effects of the Mongolian drug Amu-ru 7 on Helicobacter pylori growth and viability
- Light and Electron Microscopic Studies on the Acetylcholinesterase (AChE) activity in Auerbach's Plexus of the Developing Rat Colon
- Antimicrobial activities of clarithromycin in gnotobiotic mouse monoassociated with Mycoplasma pneumoniae
- Inhibition of cytotoxicity of Clostridium difficile in co-culture with C. butyricum MIYAIRI 588 strain in the absence of growth inhibition
- Effect of the steroid receptor antagonist RU486 (mifepristone) on an IFNγ-induced persistent Chlamydophila pneumoniae infection model in epithelial HEp-2 cells
- A novel mouse model reveals a mechanism for lung inflammation caused by Mycoplasma pneumoniae antigens
- Host immune response in gnotobiotic model of Mycoplasma pneumoniae inducing pneumonia
- Animal model of macrolide-resistant Mycoplasma pneumoniae infection
- Increased concentrations of antibody against heat shock protein in patients with myeloperoxidase anti-neutrophil cytoplasmic autoantibody positive microscopic polyangiitis
- Mycoplasma pneumoniae induces interleukin-8 production via the epidermal growth factor receptor pathway
- Purification and Properties of Branched Chain Amino Acid Aminotransferase from Gramicidin S-Producing Bacillus brevis.