Myosin Light Chain Phosphorylation is Correlated with Cold-Induced Changes in Platelet Shape
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概要
- 論文の詳細を見る
Chilling induces shape changes in platelets from disks to spheres with abundant filopodia. Such changes were time-dependent and correlated well with the phosphorylation of 20-kDa myosin light chain (LC2O). Both the shape changes and the phosphorylation were reversible. After the platelets had been chilled, myosin became incorporated into the Triton X-insoluble fraction. When the chilled platelets were immunocytochemically stained, anti-myosin antibody was localized with filamentous structures inside the filopodia. These results suggest that LC2O phosphorylation and subsequent interactions with actin filaments play a crucial role in the cold-induced changes in platelet shape and in the formation of filopodia.
- 日本平滑筋学会の論文
著者
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OHSAKA Manabu
Department of Hematology, Kitasato University School of Medicine
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HIGASHIHARA Masaaki
Department of Hematology, Kitasato University School of Medicine
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Higashihara Masaaki
あけぼの病院 内科
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Higashihara Masaaki
Section Of Hematology Fourth Department Of Internal Medicine Kitasato University School Of Medicine
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Higashihara Masaaki
北里大学 医学部第4内科(血液内科)
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Kawakami Hayato
Department of Anatomy, Kyorin University School of Medicine
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HIRANO Hiroshi
Department of Anatomy, Kyorin University School of Medicine
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Ohsaka M
Kitasato Univ. Shool Of Medicine
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Ohsaka Manabu
Department Of Hematology Kitasato University School Of Medicine
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Miyazaki Kouji
First Department of Internal Medicine and Second Department of Surgery, National Defense Medical Col
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IKEBE Mitsuo
Department of Physiology, Massachusetts Medical Center
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Kawakami Hayato
Second Dep. Of Anatomy Dep. Of Biochemistry Kyorin Univ. School Of Medicine
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Kawakami Hayato
Dept. Of Anatomy Kyorin University School Of Medicine
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Kawakami Hayato
Department Of 2nd Anatomy Kyorin University School Of Medicine
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Higashihara Masaaki
Fourth Department Of Internal Medicine School Of Medicine Kitasato University
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Higashihara Masaaki
Department Of Hematology Internal Medicine Kitasato University School Of Medicine
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Ikebe Mitsuo
Department Of Physiology Massachusetts Medical Center
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Miyazaki Kouji
Department Of Hematology Oncology Faculty Of Medicine Tokyo University
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Kawakami H
Department Of Anatomy Kyorin University School Of Medicine
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Hirano Hiroshi
Department Of Anatomy Kansai Medical School
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Hirano Hiroshi
Department Of 2nd Anatomy Kyorin University School Of Medicine
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IKEBE Mitsuo
Department of Physiology and Biophysics, Case Western Reserve University
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