CD20-Positive T-Cell Large Granular Lymphocyte Leukemia: Case Report and Review of the Literature
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概要
- 論文の詳細を見る
CD20-positive T-cell malignancy is a rare disease. We report a case of CD20-positive T-cell large granular lymphocyte leukemia (T-LGLL). The leukemic cells were positive for CD20 and T cell markers, such as CD3, CD4, CD5, CD8 and CD57. A monoclonal rearrangement of the T-cell receptor (TCR) β chain gene was detected. Twenty-three cases of well-documented CD20-positive T-cell malignancies were reviewed. Most cases were mature T-cell malignancies, especially exhibiting a cytotoxic T-cell phenotype, despite a diversity of the pathological diagnoses. Additional cases must be evaluated to clarify the implications of CD20 expression on T-cell malignancies and to elucidate whether such cases constitute a distinct biologic and clinical disease entity. The accumulation of cases will help to facilitate provision of a proper treatment for CD20-positive T-cell malignancies in the future.
著者
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MIYAZAKI Koji
Departments of Surgery, Saga Medical School
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SUZUKI Yuhko
Department of Hematology, Kitasato University School of Medicine
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HORIE Ryouichi
Department of Hematology, Kitasato University School of Medicine
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OHSAKA Manabu
Department of Hematology, Kitasato University School of Medicine
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DANBARA Mikio
Department of Hematology, Kitasato University School of Medicine
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HIGASHIHARA Masaaki
Department of Hematology, Kitasato University School of Medicine
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Suzuki Yuhko
Department Of Hematology Kitasato University School Of Medicine
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Ohsaka Manabu
Department Of Hematology Kitasato University School Of Medicine
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Danbara Mikio
Department Of Hematology Kitasato University School Of Medicine
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Higashihara Masaaki
Department Of Hematology Internal Medicine Kitasato University School Of Medicine
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Horie Ryouichi
Department Of Hematology Kitasato University School Of Medicine
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MIYAZAKI Koji
Department of Applied Chemistry, Tokyo Metropolitan University
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