Zinc-Deficiency Induced Changes in the Distribution of Rat White Blood Cells
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概要
- 論文の詳細を見る
Zinc is known to play an important role for immune-functions. However, the effects of zinc-deficiency on the immune response system from the point of view of the distribution changes of the number of total white blood cells (WBCs) are still primarily unknown. Therefore, the effects of zinc-deficiency on the number of total WBCs, neutrophil, eosinophil, basophil, monocyte and lymphocytes (T lymphocyte, B lymphocyte and NK cell) were studied in rats. The weaned male rats were randomly divided into the zinc deficient diet (ZDD: 0.7 mg zinc/kg diet) group and the control diet (CON: 34.8 mg zinc/kg diet) group, and were pair-fed for 4 wk. The number of lymphocyte subsets, visceral organ weights, serum zinc, corticosterone and IL-6 concentrations were also determined. Zinc-deficiency increased duration-dependently the number of total white blood cells, granulocytes (neutrophil, eosinophil and basophil) and monocytes in 2-4 wk without changing the number of lymphocytes, T lymphocytes, B lymphocytes or NK cells. The relative weights of thymus and adrenals were 0.63 times (p<0.01) lower and 1.60 times (p<0.001) higher in ZDD group than in CON group, respectively. Zinc-deficiency increased serum corticosterone concentration to 1.48 times (p<0.05) without changing serum IL-6 concentration, as compared with those of CON group. From these results, zinc-deficiency increases markedly the number of granulocytes and monocytes without changing the number of lymphocytes, T lymphocytes, B lymphocytes or NK cells. These results also suggest that zinc-deficiency induces stress responses and the responses may have in part participated in increased actions of the number of granulocytes and monocytes during zinc-deficiency, and induce thymus atrophy and adrenal hypertrophy.
- 財団法人 学会誌刊行センターの論文
- 2009-04-01
著者
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IMAIZUMI Kazuhiko
Laboratory of Physiological Sciences, Faculty of Human Sciences, Waseda University
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SATO Shogo
Laboratory of Physiological Sciences, Faculty of Human Sciences, Waseda University
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TACHIYASHIKI Kaoru
Department of Living and Health Sciences, Joetsu University of Education
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Nomura Sachiko
Graduate School Of Medicine Osaka University
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SHIRATO Ken
Laboratory of Physiological Sciences, Faculty of Human Sciences, Waseda University
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TANIHATA Jun
Laboratory of Physiological Sciences, Faculty of Human Sciences, Waseda University
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Tanihata Jun
Lab. Of Rehabilitation Biomedical Sciences Fac. Of Human Sciences Waseda Univ.
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Shirato Ken
Laboratory Of Physiological Sciences Faculty Of Human Sciences Waseda University
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Shirato Ken
Laboratory Of Physiological Sciences Graduate School Of Human Sciences Waseda University
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Imaizumi Kazuhiko
Laboratory Of Physiological Sciences Faculty Of Human Sciences Waseda University
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Tachiyashiki Kaoru
Department Of Living And Health Sciences Joetsu University Of Education
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KAWANO Fuuun
Laboratory of Physiological Sciences, Faculty of Human Sciences, Waseda University
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NOMURA Sachiko
Consolidated Research Institute for Advanced Science and Medical Care, Waseda University
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SOMEYA Yui
Laboratory of Physiological Sciences, Faculty of Human Sciences, Waseda University
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SUGIYAMA Mariko
Laboratory of Physiological Sciences, Faculty of Human Sciences, Waseda University
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KAWASHIMA Yu
Laboratory of Physiological Sciences, Faculty of Human Sciences, Waseda University
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Kawashima Yu
School Of Medicine University Of Yamanashi
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Someya Yui
Laboratory Of Physiological Sciences Faculty Of Human Sciences Waseda University
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Kawano Fuuun
Graduate School Of Arts And Sciences The University Of Tokyo
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Sato Shogo
Laboratory Of Physiological Sciences Faculty Of Human Sciences Waseda University
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Sugiyama Mariko
Laboratory Of Physiological Sciences Faculty Of Human Sciences Waseda University
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Tachiyashiki Kaoru
Department Of Living And Health Sciences Graduate School Of Education Joetsu University Of Education
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Kawashima Yu
Laboratory Of Physiological Sciences School Of Human Sciences Waseda University
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Imaizumi Kazuhiko
Laboratory Of Physiological Sciences School Of Human Sciences Waseda University
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