Pulmonary Vein Myocardium as a Possible Pharmacological Target for the Treatment of Atrial Fibrillation
スポンサーリンク
概要
- 論文の詳細を見る
The pulmonary vein has a unique electrophysiological property showing an autonomic electrical activity, and this phenomenon has been further focused on as a source of triggers of atrial fibrillation. The pulmonary vein cardiomyocytes have shorter action potential duration, less negative resting membrane potential, and smaller maximum upstroke velocity than those in the left atrium, whose underlying cellular mechanisms may generate arrhythmogenic substrates such as abnormal automaticity and triggered activity. In diseased conditions including sustained atrial tachycardia or chronic volume overload, its arrhythmogenic profile can be further modified through abbreviation of action potential duration of the pulmonary vein myocardium, which may become a cause of reentry. Recently, antiarrhythmic effects of various drugs have been extensively investigated in isolated pulmonary vein preparations. The present review article highlights the recent advances in our understanding of electrophysiological and pharmacological profiles of the pulmonary vein.
- 公益社団法人 日本薬理学会の論文
著者
-
Hagiwara Mihoko
Department Of Pharmacology And Therapeutics Faculty Of Pharmaceutical Sciences Toho University
-
Namekata Iyuki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Toho University
-
Tanaka Hikaru
Department of Endocrinology and Metabolism, Hirosaki University
-
Namekata Iyuki
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Japan
-
Takahara Akira
Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University, Japan
-
Takahara Akira
Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Toho University
関連論文
- Effect of T-type and L-type Ca^2+ Channel Blockade on Early Phase Ca^2+ Transients in Rat Atrial and Ventricular
- Blocking Effect of NIP-142 on the KCNQ1/KCNE1 Channel Current Expressed in HEK293 Cells
- Membrane-Labeled MDCK Cells and Confocal Microscopy for the Analyses of Cellular Volume and Morphology(Molecular and Cell Biology)
- Lack of Action Potential-Prolonging Effect of Terfenadine on Rabbit Myocardial Tissue Preparations(Pharmacology)
- In Vivo Electropharmacological Effects of Amiodarone and Candesartan on Atria of Chronic Atrioventricular Block Dogs
- Comparison of Four Rate-Correction Algorisms for the Ventricular Repolarization Period in Assessing Net Effects of I_ Blockers in Dogs
- New Aspects for the Treatment of Cardiac Diseases Based on the Diversity of Functional Controls on Cardiac Muscles : Diversity in the Excitation-Contraction Mechanisms of the Heart
- New Aspects for the Treatment of Cardiac Diseases Based on the Diversity of Functional Controls on Cardiac Muscles: Diversity in the Excitation–Contraction Mechanisms of the Heart
- Species Difference in the Contribution of T-Type Calcium Current to Cardiac Pacemaking as Revealed by R(-)-Efonidipine
- OJ-071 Chronic Atrioventricular Block Abbreviated the Action Potential Duration of Canine Pulmonary Vein Myocardium(Arrythmia, basic(02)(A),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Analysis of Arrhythmogenic Profile in a Canine Model of Chronic Atrioventricular Block by Comparing In Vitro Effects of the Class III Antiarrhythmic Drug Nifekalant on the Ventricular Action Potential Indices Between Normal Heart and Atrioventricular Bloc
- Muscarinic Receptor Subtypes Mediating Positive and Negative Inotropy in the Developing Chick Ventricle
- Atria Selective Prolongation by NIP-142, an Antiarrhythmic Agent, of Refractory Period and Action Potential Duration in Guinea Pig Myocardium
- Effect of NIP-142 on Potassium Channel α-Subunits Kv1.5, Kv4.2 and Kv4.3, and Mouse Atrial Repolarization
- New Aspects for the Treatment of Cardiac Diseases Based on the Diversity of Functional Controls on Cardiac Muscles : Novel Approaches for the Diagnosis and Treatment of Cardiac Diseases
- Involvement of the Na^+/Ca^ Exchanger in the Automaticity of Guinea-Pig Pulmonary Vein Myocardium as Revealed by SEA0400
- Immunohistochemical Mucin Expression of Short-Segment Barrett's Esophagus
- Preliminary Study for Sentinel Lymph Node Identification with Tc-99m Tin Colloid in Patients with Esophageal or Gastric Cancer
- The R(-)-Enantiomer of Efonidipine Blocks T-type but Not L-type Calcium Current in Guinea Pig Ventricular Myocardium
- Effect of Cilnidipine on L- and T-type Calcium Currents in Guinea Pig Ventricle and Action Potential in Rabbit Sinoatrial Node
- Constitutional Rho-Kinase Regulates the Electrophysiological and Mechanical Function of the Heart Besides the Coronary Vascular Tone
- Cardiac Effects of a Selective Rho-Associated Kinase Inhibitor, Y-27632, Assessed in Canine Isolated, Blood-Perfused Heart Preparations
- Progressive systemic sclerosis associated with primary small cell carcinoma of the stomach
- P-42 Lack of Action Potential Prolonging Effect of Terfenadine on Myocardial Tissue Preparations.(Proceedings of the 27th Annual Meeting)
- Pathophysiological Significance of T-type Ca^ Channels : T-type Ca^ Channels and Drug Development
- Inhibition of Agonist-Induced Positive Inotropy by a Selective Rho-Associated Kinase Inhibitor, Y-27632
- Pharmacological Evidence for Involvement of Phospholipase D, Protein Kinase C, and Sodium-Calcium Exchanger in α-Adrenoceptor-Mediated Negative Inotropy in Adult Mouse Ventricle
- A Case of Superficial Esophageal Cancer Complicated with Idiopathic Muscular Hypertrophy of the Esophagus
- Involvement of Intracellular Ca^ in the Regulatory Volume Decrease After Hyposmotic Swelling in MDCK Cells
- Involvement of the Na^+/Ca^ Exchanger in Ouabain-Induced Inotropy and Arrhythmogenesis in Guinea-Pig Myocardium as Revealed by SEA0400
- Quantitative Fluorescence Measurement of Cardiac Na^+/Ca^ Exchanger Inhibition by Kinetic Analysis in Stably Transfected HEK293 Cells
- Simultaneous Real-Time Detection of Initiator- and Effector-Caspase Activation by Double Fluorescence Resonance Energy Transfer Analysis
- Effect of Manganese on Guinea Pig Ventricle : Initial Depression and Late Augmentation of Contractile Force
- Restricted Propagation of Cytoplasmic Ca^ Oscillation into the Nucleus in Guinea Pig Cardiac Myocytes as Revealed by Rapid Scanning Confocal Microscopy and Indo-1
- Simultaneous Assessment of Pharmacokinetics of Pilsicainide Transdermal Patch and Its Electropharmacological Effects on Atria of Chronic Atrioventricular Block Dogs
- Comparison of Electropharmacological Effects of Bepridil and Sotalol in Halothane-Anesthetized Dogs
- OJ-006 Comparison of Electropharmacological Effects of Sotalol and Bepridil Assessed in the in Vivo Canine Heart(Cardiovascular pharmacology, basic/clinical-2 (H) OJ1,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japan
- Endoscopic Screening for Esophageal Cancer in 788 Patients with Head and Neck Cancers
- A Red Wine Vinegar Beverage can Inhibit the Renin-Angiotensin System : Experimental Evidence in Vivo(Pharmacology)
- The Endothelium-Dependent Vasodilator Action of a New Beverage Made of Red Wine Vinegar and Grape Juice(Pharmacology)
- Dangerous QT Prolongation Can be Assayed with Two Types of In Vivo Models ; Halothane-Anesthetized Dog and Chronic Atrioventricular Block Dog(Cardiovascular Pharmacology, Basic/Clinical 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation
- The Antipsychotic and Antiemetic Drug Prochlorperazine Delays the Ventricular Repolarization of the In Situ Canine Heart
- Electropharmacological Effects of a Spironolactone Derivative, Potassium Canrenoate, Assessed in the Halothane-Anesthetized Canine Model
- PE-353 Mexiletine Decreased the Ventricular Electrical Vulnerability in the Canine Model of Sparfloxacin-Induced Long QT Syndrome(Cardiovascular Pharmacology, Basic/Clinical 3 (H) : PE60)(Poster Session (English))
- OE-275 A Spironolactone Derivative, Potassium Canrenoate, Prolongs the QT Interval but Shortens the Electrically Vulnerable Period of In Vivo Canine Hearts(Cardiovascular Pharmacology, Basic/Clinical 1 (H) : OE34)(Oral Presentation (English))
- The QT-Prolonging Effects of a Histamine H1 Receptor Antagonist Terfenadine Assessed in the In Vivo Canine Heart Model: Comparison of the Rate-Correcting Methods for the Ventricular Repolarization Periods
- Relationship Between Phosphodiesterase Inhibition Induced by Several Kampo Medicines and Smooth Muscle Relaxation of Gastrointestinal Tract Tissues of Rats
- Cardiovascular and Adenylate Cyclase Stimulating Effects of Colforsin Daropate, a Water-Soluble Forskolin Derivative, Compared With Those of Isoproterenol, Dopamine and Dobutamine
- Blockade by NIP-142, an Antiarrhythmic Agent, of Carbachol-Induced Atrial Action Potential Shortening and GIRK1/4 Channel
- Comparison of the Inhibitory Effects of Docosahexaenoic Acid (DHA) on U46619-and Phenylephrine-Induced Contractions in Guinea-Pig Aorta(Pharmacology)
- Propagation of Normal and Abnormal Cytoplasmic Ca^ Oscillation into the Cell Nucleus in Cardiomyocytes
- Effects of a Novel Vesamicol Receptor Ligand, m-(Iodobenzyl)trozamicol, on the Canine Isolated, Blood-Perfused Atrioventricular Node Preparation
- Effects of Sildenafil (Viagra TM) on the Cyclic AMP Hydrolyzing Phosphodiesterase Activity in the Canine Heart Assessed Using a Modified Enzymatic Fluorometric Assay Technique
- DECREASE OF PLASMA SULFUR AMINO ACIDS IN ESSENTIAL HYPERTENSION
- Functional Contribution of Voltage-Dependent and Ca^2+-Activated K^+ (BK_ca) Channels to the Relaxation of Guinea-Pig Aorta in Response to Natriuretic Peptides
- Phospholipase C Inhibitors Suppress Spontaneous Mechanical Activity of Guinea Pig Urinary Bladder Smooth Muscle(Pharmacology)
- Studies on Vascular Endothelial Cell Damage by Polidocanol in Relation to Concentration, Ethylene-oxide Chain Length and Exposure Time
- Cardiac Effects of Clinically Available Kampo Medicine Assessed With Canine Isolated, Blood-Perfused Heart Preparations
- Famotidine neither affects action potential parameters nor inhibits human ether-a-go-go-related gene (hERG) K^+ current
- Characterization of the Halothane-Anesthetized Guinea-Pig Heart as a Model to Detect the K^+ Channel Blocker-Induced QT-Interval Prolongation(Pharmacology)
- PJ-719 Beat-to-beat Variability of Ventricular Repolarization Period Can Predict Onset of Acquired Long QT Syndrome(Arrhythmia, basic-6 (A) PJ121,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-345 Long-term Blockade of N-type Ca^ Channels Reversed the Ventricular Electrical Remodeling in the Canine Model of Long QT Syndrome(Cardiovascular pharmacology, basic/clinical-4 (H) PJ58,Poster Session (Japanese),The 70th Anniversary Annual Scient
- Halothane Sensitizes the Guinea-Pig Heart to Pharmacological I_ Blockade : Comparison With Urethane Anesthesia
- A Simple In Vivo Atrial Fibrillation Model of Rat Induced by Transesophageal Atrial Burst Pacing
- Utility of Short-Term Variability of Repolarization as a Marker for Monitoring a Safe Exercise Training Program in Patients With Cardiac Diseases
- Cardiac Effects of Salvia Miltiorrhiza/Dalbergia Odorifera Mixture, an Intravenously Applicable Chinese Medicine Widely Used for Patients With Ischemic Heart Disease in China
- H2 Receptor-Mediated Positive Inotropic Effect of Histamine in Neonatal Guinea-Pig Left Atria
- Optical Bioimaging : From Living Tissue to a Single Molecule : Preface
- Quantitative Fluorescence Measurement of Cardiac Na+/Ca2+ Exchanger Inhibition by Kinetic Analysis in Stably Transfected HEK293 Cells
- Measurements of Cardiac Ion Channel Subunits in the Chronic Atrioventricular Block Dog
- Developmental Changes in Action Potential Prolongation by K^+-Channel Blockers in Chick Myocardium
- Electrophysiological and Pharmacological Characteristics of Triggered Activity Elicited in Guinea-Pig Pulmonary Vein Myocardium
- Electrophysiological Effects of the Class Ic Antiarrhythmic Drug Pilsicainide on the Guinea-Pig Pulmonary Vein Myocardium
- Comparative Study of the Analytical Values and Food Composition Table Values of Proteins and the Proportions of their Amino Acid Components in Foods
- Study on Associations between Reduced Numbers of Remaining Teeth and Reduced Protein Intake and Hypoalbuminemia
- Effects of the Antitussive Drug Cloperastine on Ventricular Repolarization in Halothane-Anesthetized Guinea Pigs
- Electrical Activity of the Mouse Pulmonary Vein Myocardium
- Analysis of Glycemic Variability and Insulin Resistance in Patients with Pancreatic Diabetes Using a Continuous Glucose Monitoring System
- Electrical Activity of the Mouse Pulmonary Vein Myocardium
- Effects of the Fluoroquinolone Antibacterial Drug Ciprofloxacin on Ventricular Repolarization in the Halothane-Anesthetized Guinea Pig
- Electrophysiological Effects of the Antiarrhythmic Drug Bepridil on the Guinea-Pig Pulmonary Vein Myocardium
- Electrophysiological and Pharmacological Properties of the Pulmonary Vein Myocardium
- Developmental Changes in Excitation–Contraction Mechanisms of the Mouse Ventricular Myocardium as Revealed by Functional and Confocal Imaging Analyses
- Effect of Cilnidipine on L- and T-type Calcium Currents in Guinea Pig Ventricle and Action Potential in Rabbit Sinoatrial Node
- The Conventional Antihistamine Drug Cyproheptadine Lacks QT-interval–Prolonging Action in Halothane-Anesthetized Guinea Pigs: Comparison With Hydroxyzine
- Positive Immunostaining with Dystrophin Antibodies in mdx Skeletal Muscle.
- Effects of the Antitussive Drug Cloperastine on Ventricular Repolarization in Halothane-Anesthetized Guinea Pigs
- Pulmonary Vein Myocardium as a Possible Pharmacological Target for the Treatment of Atrial Fibrillation