Effect of neuroactive peptides on labeled 5-hydroxytryptamine release from rat spinal slices in vitro.
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概要
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Effects of neuroactive peptides on the release of labeled 5-hydroxytryptamine (5-HT) from preloaded rat spinal cord slices were investigated. The 5-HT release was significantly stimulated by somatostatin (10-50 μM) and substance P (10-50 μM), but not by neurotensin (50 μM), 8-endorphin (30 μM) and methionine-enkephalin (met-enk) (100 μM). Somatostatin-stimulated 5-HT release was markedly inhibited by γ-aminobutyric acid (GABA) (30 μM), but not by baclofen (30 μM) and met-enk (100 μM). Substance P-stimulated 5-HT release was strongly inhibited by GABA (30 μM) and baclofen (30 μM), but not by met-enk (100 μM). High concentrations (20 mM) of potassium also stimulated 5-HT release. The high potassium-stimulated 5-HT release was not affected by GABA (30 μM) and met-enk (100 μM). These results suggested further evidence on the important role of somatostatin and substance P as modulators of serotonergic neurones.
- 公益社団法人 日本薬理学会の論文
著者
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Maeda Sadaaki
Department Of Pharmacology Faculty Of Dentistry Osaka University
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TSAI Huei-Yann
Department of Pharmacology, China Medical College
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INOKI Reizo
Department of Pharmacology, Osaka University Dental School
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IWATSUBO Katsuya
Department of Pharmacology, Faculty of Dentistry, Osaka University
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