Effects of noxious stimuli and anesthetic agents on substance P content in rat central nervous system.
スポンサーリンク
概要
- 論文の詳細を見る
Effects of noxious electrical tooth stimulations and intraarterial administration of bradykinin or inhalation of volatile anesthetics on substance P content in the diencephalon-mesencephalon, pons-medulla and the spinal cord were examined in the rat. Noxious stimulation by electrical long duration stimulation (type 2) of tooth pulp caused an increase of substance P content in the ponsmedulla. Inhalation of volatile anesthetics such as methoxyflurane and diethylether produced an increase of substance P content in the spinal cord; and in addition, methoxyflurane produced a decrease of substance P content in ponsmedulla. However, halothane did not produce any changes in substance P content in any parts of the central nervous system (CNS). These results suggest that volatile anesthetics such as diethyl-ether and methoxyflurane act on the substance P neuron and may modulate pain transmission through the action of substance P in the pons-medulla or the spinal cord.
- 公益社団法人 日本薬理学会の論文
著者
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INOKI Reizo
Department of Pharmacology, Osaka University Dental School
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Sugiyama Kazuna
Department Of Dental Anesthesia Kagoshima University Dental Hospital
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HIROTA Yasuaki
Department of Dental Anesthesiology, Faculty of Dentistry, Osaka University
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MATSUURA Hideo
Department of Dental Anesthesiology, Faculty of Dentistry, Osaka University
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KOTANI Yoshito
Department of Dental Anesthesiology, Faculty of Dentistry, Osaka University
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JOH Shigeharu
Department of Dental Anesthesiology, Faculty of Dentistry, Osaka University
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SHIBUTANI Tohru
Department of Dental Anesthesiology, Faculty of Dentistry, Osaka University
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