Effect of Neurotropin on Hyperalgesia Induced by Prostaglandin E<SUP>2</SUP>, Naloxone, Melatonin and Dark Condition in Mice
スポンサーリンク
概要
- 論文の詳細を見る
Subcutaneous injection of formaldehyde into mouse hind paw elicited pain responses consisting of licking or biting of the paw, which were observed biphasically. The first and second phases were enhanced by melatonin and melatonin, naloxone, prostaglandin E<SUP>2</SUP>, respectively. Mice kept in the dark also exhibited hyperalgesic response. When neurotropin was injected intraperitoneally 30 min prior to those treatments, hyperalgesia was suppressed to the control level. Aspirin inhibited only the second hyperalgesic phase.
著者
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INOKI Reizo
Department of Pharmacology, Osaka University Dental School
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Shibata Manabu
Department Of Chemistry Faculty Of Science Tohoku University
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Takahashi Hiroshi
Department Of Applied Aquabiology National Fisheries University
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OHKUBO Tsuyako
Department of Pharmacology, Fukuoka Dental College
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SAITO Kihachi
Department of Pharmacology I, Osaka University School of Medicine
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