Coronary Plaque Regression and Lifestyle Modification in Patients Treated With Pravastatin : Assessment Mainly by Daily Aerobic Exercise and an Increase in the Serum Level of High-Density Lipoprotein Cholesterol

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概要

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• Background: The purpose of this study was to explore the effect of lifestyle modification, mainly daily aerobic exercise, on coronary atherosclerosis in patients with coronary artery disease (CAD). Methods and Results: A 6-month prospective observational study was conducted with 84 CAD patients receiving pravastatin treatment in order to evaluate the relationship between lifestyle modification, in particular aerobic exercise, and plaque volume as assessed by intravascular ultrasound (IVUS). Lifestyle during the study period was assessed by the-lifestyle modification score. A significant decrease in plaque volume by 12.9% was observed after 6 months of pravastatin therapy (P<0.0001 vs baseline). The change in plaque volume correlated with the change in the serum level of high-density lipoprotein cholesterol (HDL-C) (r=-0.549, P<0.0001), non-HDL-C (r=0.248, P=0.03), low-density lipoprotein cholesterol/HDL-C (r=0.505, P<0.0001), apolipoprotein (apo) A-1 (r=-0.335, P=0.007) and apoB/apoA-1 (r=0.335, P=0.007), and lifestyle modification score (r=-0.616, P<0.0001). There was a clear positive correlation between a change in the serum HDL-C level and lifestyle modification score. Multivariate regression analysis revealed that the increase in serum HDL-C level and lifestyle modification score were independent predictors of coronary plaque regression. Conclusions: An appropriate combination of statin therapy and lifestyle modification, in particular, physical activity, may result in coronary plaque regression. This combined treatment strategy, inducing an increase of the serum HDL-C, may contribute to coronary plaque regression.

• 2010-04-25

著者

• HIRAYAMA Atsushi

  Osaka Police Hospital

• HIRAYAMA Atsushi

  Division of Cardiology, Department of Medicine, Nihon University School of Medicine

• Hirayama Atsushi

  Division Of Cardiovascular Medicine Department Of Medicine Nihon University School Of Medicine

• Nagao Ken

  Department of Cardiology, Nihon University Surugadai Hospital

• Takei Hiroshi

  Department Of Cardiology Nihon University Surugadai Hospital

• Hirayama A

  Division Of Cardiovascular Medicine Department Of Medicine Nihon University School Of Medicine

• Takahashi Hiroshi

  Department of Cardiology, Nagoya Kyoritsu Hospital

• Tani Shigemasa

  Departments of Cardiology

• Hirata Akio

  大阪警察病院 心臓セ

• Anazawa Takeo

  Department of Cardiology, Nihon University Surugadai Hospital

• Kawamata Hirofumi

  Department of Cardiology, Nihon University Surugadai Hospital

• Matsumoto Michiaki

  Department of Cardiology, Surugadai Nihon University Hospital

• Matsumoto Michiaki

  Department Of Cardiology Nihon University Surugadai Hospital

• Washio Takehiko

  Department of Cardiology, Kawaguchi Municipal Medical Center

• Kumabe Narimichi

  Department of Cardiology, Nihon University Surugadai Hospital

• Iida Kiyoshi

  Department of Cardiology, Nihon University Surugadai Hospital

• Furuya Shingo

  Department of Cardiolugy, Nihon University Surugadai Hospital

• Kotani Hirofumi

  Department Of Cardiology Nihon University School Of Medicine

• Kawamata Hirofumi

  Department Of Cardiology Nihon University Surugadai Hospital

• Nagao Ken

  Division Of Cardiology Department Of Medicine Nihon University School Of Medicine

• Kajiwara Nagao

  Dept. Of Cardiology Surugadal Nihon University Hospital

• Hirayama Atsushi

  Division Of Cardiology Department Of Medicine Nihon University School Of Medicine

• Hirayama Atsushi

  日本大学 医学部内科学系循環器内科

• Hanatani Akihisa

  国立循環器病研究センター 心臓血管内科部門

• Akamatsu Hiroki

  Department Of Cardiology Nihon University Surugadai Hospital

• Tani Shigemasa

  Department Of Cardiology Nihon University Surugadai Hospital

• Asai Takae

  Divisions Of Cardiology Nihon University School Of Medicine

• Nagao Ken

  SOS-KANTO Investigators

• Furuya Shingo

  Department Of Cardiology Nihon University Surugadai Hospital

• Abeta Hiromi

  Department Of Cardiology Surugadai Nihon University Hospital

• Hirayama Atsushi

  Department Of Cardiology Nihon University School Of Medicine

• Tani Shigemasa

  Department Of Cardiology Nihon University School Of Medicine

• Anazawa Takeo

  The Department Of Cardiology Surugadai Nihon University Hospital

• Kumabe Narimichi

  Department Of Cardiology Nihon University Surugadai Hospital

• Takahashi Hiroshi

  Department Of Cardiology Nihon University Surugadai Hospital

• Iida Kiyoshi

  Department Of Cardiology Nihon University Surugadai Hospital

• Matsumoto Michiaki

  Department Of Applied Chemistry Oita University

• Tani Shigemasa

  Department Of Cardiology Nihon University School Of Medicine Tokyo

• Nagao Ken

  Tokyo Coronary Care Unit Network

• Anazawa Takeo

  Department Of Cardiology Nihon University School Of Medicine

• Washio Takehiko

  Department Of Cardiology Nihon University Surugadai Hospital

• Nagao Ken

  Department Of Emergency And Critical Care Medicine Surugadai Nihon University Hospital

• Tomiyama Hirofumi

  Department Of Cardiology Surugadai Nihon University Hospital

• Nagao Ken

  Department Of Cardiology Cardiopulmonary Resuscitation And Emergency Cardiovascular Care Surugadai N

• Hirayama Atsushi

  Division Of Cardiology Department Of Internal Medicine Nihon University School Of Medicine

• Aoyama Hiroshi

  Department Of Cardiology Surugadai Nihon University Hospital

• Furuhashi Satoru

  Radiology Nihon University School Of Medicine

• Matsuzaki Masakazu

  Department Of Cardiology Resuscitation And Emergency Cardiovascular Care Surugadai Nihon University

• Nagao Ken

  Department Of Cardiology Surugadai Nihon University Hospital

• Kajiwara Nagao

  Dept. Of Cardiovas. Dis. Surugadai Hosp. School Of Med.

• Nagao Ken

  Department Of Cardiology Resuscitation And Emergency Cardiovascular Care Surugadai Nihon University

• Matsuzaki Masakazu

  Department Of Cardiology Resuscitation And Emergency Cardiovascular Care Surugadai Nihon University Hospital

• Takahashi Hiroshi

  Department Of Applied Aquabiology National Fisheries University

• Kujiwara Nagao

  Department Of Cardiology Surugadai Nihon University Hospital.

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