Interaction of bradykinin with substance P on vascular permeability and pain response.
スポンサーリンク
概要
- 論文の詳細を見る
Combination of bradykinin with substance P exerted synergistic effects on vascular permeability and pain response in mouse paw. Denervation of sciatic nerve reduced significantly bradykinin-induced vascular permeability, suggesting the involvement of sensory nerves. The bradykinin-induced vascular permeability was also reduced by intravenous injection of a substance P-antagonist. The results suggest that neuronal substance P takes part in the action of bradykinin on inflammation and pain sensation.
- 公益社団法人 日本薬理学会の論文
著者
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INOKI Reizo
Department of Pharmacology, Osaka University Dental School
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Shibata Manabu
Department Of Chemistry Faculty Of Science Tohoku University
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Takahashi Hiroshi
Department Of Applied Aquabiology National Fisheries University
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OHKUBO Tsuyako
Department of Pharmacology, Fukuoka Dental College
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