Further evidence for the possible relationship between neuropeptides and serotonergic neurones in rat spinal cord.

スポンサーリンク

概要

• 論文の詳細を見る

• The relationship between neuropeptides and serotonergic neurones was investigated in rat spinal cord, in vivo, using a subarachnoidal perfusion technique. The 5-hydroxytryptamine (5-HT) release from the spinal cord could be evoked by substance P and peripheral pain stimulation (tail pinch), but not by methionine-enkephalin (met-EK). The substance P-evoked 5-HT release was slightly potentiated by met-EK. The tail pinch-evoked 5-HT release was inhibited by met-EK and baclofen, but potentiated by naloxone. These findings may infer a possible mechanism by which neuroactive peptides regulate 5-HT release from serotonergic neurones in the spinal cord.

• 公益社団法人 日本薬理学会の論文

著者

• TSAI Huei-Yann

  Department of Pharmacology, China Medical College

• TSAI Huei-Yann

  Department of Pharmacology, Faculty of Dentistry, Osaka University

関連論文

• EFFECT OF SOMATOSTATIN ON LABELED 5-HYDROXYTRYPTAMINE RELEASE FROM RAT SPINAL CORD AND METHIONINE ENKEPHALIN ANTAGONISM IN VIVO
• Effect of neuroactive peptides on labeled 5-hydroxytryptamine release from rat spinal slices in vitro.
• Further evidence for the possible relationship between neuropeptides and serotonergic neurones in rat spinal cord.

スポンサーリンク