Caspase-4 Directly Activates Caspase-9 in Endoplasmic Reticulum Stress–Induced Apoptosis in SH-SY5Y Cells
スポンサーリンク
概要
- 論文の詳細を見る
The present study investigated the function of caspase-4 in endoplasmic reticulum (ER) stress–induced apoptosis in human neuronal cell line SH-SY5Y. Tunicamycin, which is known to induce ER stress, activated both caspase-9 and caspase-4, and the activation of caspase-4 preceded that of caspase-9. The caspase-4 inhibitor LEVD-CHO suppressed both the apoptosis and caspase-9 activation. In addition, human recombinant active caspase-4 cleaved wild type and D330A mutant substituted Asp-330 for alanine of human recombinant procaspase-9, but did not cleave D315A mutant substituted Asp-315 for alanine. These results suggest that caspase-4 directly activates caspase-9 by the processing of procaspase-9 at Asp-315 in ER stress–induced neuronal apoptosis.
著者
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Yoshioka Yasuhiro
Department of Pharmacotherapeutics, Faculty of Pharmaceutical Sciences, Setsunan University, Japan
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Yamamuro Akiko
Department of Pharmacotherapeutics, Faculty of Pharmaceutical Sciences, Setsunan University, Japan
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Kasai Atsushi
Department of Pharmacotherapeutics, Faculty of Pharmaceutical Sciences, Setsunan University, Japan
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Maeda Sadaaki
Department of Pharmacotherapeutics, Faculty of Pharmaceutical Sciences, Setsunan University, Japan
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Kimura Tomoki
Department of Toxicology, Faculty of Pharmaceutical Sciences, Setsunan University
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Kishino Takashi
Department of Pharmacotherapeutics, Faculty of Pharmaceutical Sciences, Setsunan University, Japan
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Ohshima Yu
Department of Pharmacotherapeutics, Faculty of Pharmaceutical Sciences, Setsunan University, Japan
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Yoshioka Yasuhiro
Department Of Electronic Enginnering Faculty Of Engineering Yamanashi University:(present Address)cl
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Maeda Sadaaki
Department Of Pharmacology Faculty Of Dentistry Osaka University
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Kimura Tomoki
Department Of Radiology Kagawa University
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Kasai Atsushi
Department Of Pharmacotherapeutics Faculty Of Pharmaceutical Sciences Setsunan University
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Kishino Takashi
Department Of Pharmacotherapeutics Faculty Of Pharmaceutical Sciences Setsunan University
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Ohshima Yu
Department Of Pharmacotherapeutics Faculty Of Pharmaceutical Sciences Setsunan University
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