Noninvasive Ventilation in Acute Exacerbation of Idiopathic Pulmonary Fibrosis
スポンサーリンク
概要
- 論文の詳細を見る
Background and Objective The outcome of acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is usually very poor, and it has been suggested that mechanical ventilation does not benefit AE-IPF patients. Noninvasive ventilation (NIV) has attracted attention as a means to avoid intubation in acute respiratory failure, including acute respiratory distress syndrome (ARDS). This study describes the outcome of patients with AE-IPF who were treated with NIV. Methods Patients included in the study were those who fulfilled the criteria for AE-IPF during the periods between April 1998 and June 2004 at Tosei General Hospital, and in whom NIV was introduced. Clinical data were obtained retrospectively from patient records. Results This study included 11 patients. The initial NIV settings were continuous positive airway pressure (CPAP) mode in 6 patients (mean 10.1±2.5 cmH2O) and Spontaneous/Timed mode in 5 (mean inspiratory positive airway pressure/expiratory positive airway pressure; 15.0±3.3/10.2±2.9 cmH2O). Five patients avoided intubation and survived more than 3 months after AE-IPF. Six patients who failed NIV died within 3 months. In these 6 patients, 4 required intubation. The other 2 patients, who refused endotrachial intubation, died without intubation. Median survival time and 3-month survivals after acute exacerbation were 30 days, and 45.5%, respectively. Conclusion Considering extremely poor prognosis of AE-IPF, our findings suggest that NIV is a viable option for the respiratory management in AE-IPF, and should be studied in a large, well-controlled trial.
著者
-
Kimura Tomoki
Department of Toxicology, Faculty of Pharmaceutical Sciences, Setsunan University
-
Kubo Keishi
The First Department of Internal Medicine, Shinshu University School of Medicine
-
Kato Keisuke
Department of Organic Chemistry, Faculty of Pharmaceutical Sciences, Toho University
-
Yokoyama Toshiki
The First Department of Internal Medicine, Shinshu University School of Medicine
-
Kondoh Yasuhiro
Department of Respiratory Medicine and Allergy, Tosei General Hospital
-
Taniguchi Hiroyuki
Department of Respiratory Medicine and Allergy, Tosei General Hospital
-
Kataoka Kensuke
Department of Respiratory Medicine and Allergy, Tosei General Hospital
-
Nishiyama Osamu
Department of Respiratory Medicine and Allergy, Tosei General Hospital
-
Hasegawa Ryuichi
Department of Critical Care and Intensive Care Medicine, Tosei General Hospital
-
Kondoh Yasuhiro
Department Of Respiratory Medicine And Allergy Tosei General Hospital
-
Nishiyama Osamu
Department Of Cardiology Iwate Medical University
-
Taniguchi Hiroyuki
Department Of Electronic Engineering Nihon University
-
Kubo Keishi
The First Department Of Internal Medicine Shinshu University
-
Kato Keisuke
Department Of Biological Sciences Graduate School Of Science The University Of Tokyo
-
Kataoka Kensuke
Department Of Applied Chemistry School Of Engineering Tokai University
-
Kimura Tomoki
Department Of Radiation Oncology Hiroshima University Graduate School Of Biomedical Sciences
-
Kato Keisuke
Department of Respiratory Medicine and Allergy, Tosei General Hospital
関連論文
- Molecular Mechanisms of Zinc-mediated Induction and Chromium(VI)-mediated Inhibition of Mouse Metallothionein-I Gene Transcription
- Noninvasive Ventilation in Acute Exacerbation of Idiopathic Pulmonary Fibrosis
- Development of a Quinazoline-Based Chelating Ligand for Zinc Ion and Its Application to Validation of a Zinc-Ion-Coordinated Compound
- Evaluation of Respiratory Impedance in Asthma and COPD by an Impulse Oscillation System
- Hemorrhagic rectal ulcer caused by a deformity of the coccyx complicated by normal delivery
- Clinical characteristics of combined pulmonary fibrosis and emphysema
- Effects of a synthetic protease inhibitor (gabexate mesilate) and a neutrophil elastase inhibitor (sivelestat sodium) on acid-induced lung injury in rats
- Evaluation of Respiratory Impedance in Asthma and COPD by an Impulse Oscillation System
- A Case of Interstitial Pneumonia Induced by Rituximab Therapy
- PE-308 Serial Changes on Quantative Myocardial 99mTc-Trtrofosmin Uptake in Patients Undergoing Revasculization in Stable Coronary Artery Disease(Cardiovascular Surgery/CABG 3 (IHD) : PE53)(Poster Session (English))
- Caspase-4 Directly Activates Caspase-9 in Endoplasmic Reticulum Stress–Induced Apoptosis in SH-SY5Y Cells
- Elemental analysis of inorganic dusts in lung tissues of interstitial pneumonias
- Metal Response Element-binding Transcription Factor-1 Is Activated by Degradation of Metallothionein
- Computer Generated Rainbow Hologram
- Acute Hypoxic Pulmonary Vascular Response Does Not Accompany Plasma Endothelin-1 Elevation in Subjects Susceptible to High Altitude Pulmonary Edema
- Pulmonary Hypertension as a Result of Asymptomatic Portosystemic Shunt
- Sustained High Levels of Circulatory Interleukin-8 are Associated with a Poor Outcome in Patients with Adult Respiratory Distress Syndrome
- Function of Metallothionein in Gene Expression and Signal Transduction : Newly Found Protective Role of Metallothionein
- Mechanisms of Heavy Metal Sensing by Metal Response Element-binding Transcription Factor-1
- Effect of Metallothionein on Doxorubicin-induced Hepatotoxicity(PROCEEDINGS OF 24TH SYMPOSIUM ON TOXICOLOGY AND ENVIRONMENTAL HEALTH)
- 3C-06 Hepatoprotection by zinc and sakuraso-saponin in metallothionein-deficient mice
- Catamenial Hemoptysis
- Diffuse Pulmonary Amyloidosis with Monoclonal IgG-kappa Gammopathy
- Evaluating Health-related Quality of Life in Asthma
- Cardiovascular responses to high-frequency oscillatory ventilation during acute lung injury in sheep
- Effect of tube guide assembly of closed suction system on airway pressure gradient
- Evaluation of Tube Compensation in the Bennett 840 Ventilator-A New Ventilatory Mode to Support Spontaneous Breathing
- Differences in Respiratory Parameters during Continuous Positive Airway Pressure and Pressure Support Ventilation in Infants and Children
- Immunoblastic lymphadenopathy-like T-cell lymphoma complicated by multiple gastrointestinal involvement
- Successful Treatment of Fungus Ball in a Patient with Allergic Bronchopulmonary Aspergillosis: Continuous Percutaneous Instillation of Antifungal Agents into the Cavity
- Polymyxin B-immobilized Fiber Column Hemoperfusion Treatment for Drug-Induced Severe Respiratory Failure: Report of Three Cases
- Selective IgM Deficiency Accompanied with IgG4 Deficiency, Dermal Complications and a Bronchial Polyp
- Protective Effect of Zinc against Lipopolysaccharide/D-Galactosamine-Induced Lethality
- Metallothionein-Null Mice Are Sensitive to Endotoxine/D-Galactosamine-Induced Hepatotoxicity
- 22C-10-4 Lipopolysaccharide-Induced Lethality in D-Galactosamine-Sensitized Metallothionein-Null Mice.
- Double cancer (Iung and colon cancer) that showed complete remission with irinotecan and cisplatin combined chemotherapy
- Acute Pulmonary Edema Caused by Accidental Aspiration of Sweetened Water in Two Cases of Diabetes Mellitus
- Spontaneous Pneumomediastinum: Origin Identified by Chest Computed Tomography
- EFFECTS OF HYDRALAZINE ON ACUTE HYPOXIC PULMONARY VASOCONSTRICTION IN CONSCIOUS SHEEP : Pulmonary Circulation : I : 48 Annual Scientific Meeting, Japanese Circulation Society
- EFFECTS OF CAPTOPRIL ON ACUTE HYPOXIC PULMONARY VASOCONSTRICTION IN CONSCIOUS SHEEP : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Pulmonary Circulation
- EFFECTS OF INCREASED LEFT ATRIAL PRESSURE AND ENDOTOXIN INFUSION ON PULMONARY HEMODYNAMICS AND LUNG FLUID BALANCE IN CONSCIOUS SHEEP : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Pulmonary Circulation
- THE EFFECT OF Ca^ANTAGONIST VERAPAMIL ON RIGHT VENTRICULAR HYPERTROPHY OF RATS EXPOSED AT HIGH ALTITUDE : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Cardiovascular Drugs (I)
- Chromium (VI) inhibits mouse metallothionein-I gene transcription by modifying the transcription potential of the co-activator p300
- Mediastinal Growing Teratoma Syndrome Succesfully Treated by Multiple Modality Therapies
- -345-PULMONARY EDEMA DUE TO ACUTE CORONARY OCCLUSION IN AWAKE SHEEP
- EFFECTS OF PROSTACYCLIN (PGI_2) ON HYPOZICPULMONARY VASOCONSTRICTION IN THE CONSCIOUS ADULT SHEEP
- EFFECTS OF INCREASED LEFT ATRIAL PRESSURE AND E.coli ENDOTOXIN INFUSION ON LUNG LYMPH BALANCE AND EXTRAVASCULAR LUNG THERMAL VOLUME IN ANESTHETIZED SHEEP : Pulmonary Circulation : I : 48 Annual Scientific Meeting, Japanese Circulation Society
- HEMODYNAMIC RESPONSES TO PROSTACYCLIN(PGI_2)IN THE CONSCIOUS SHEEP
- EFFECTS OF PROSTAGLANDIN E_1 (PGE_1) AND ISOSORBIDE DINITRATE (ISD) ON ACUTE ALVEOLAR HYPOXIC PULMONARY VASOCONSTRICTION IN AWAKE STANDING SHEEP : Pulmonary Circulation : 46th Annual Scientific Meeting, Japanese Circulation Society
- CARDIOVASCULAR EFFECTS OF PROSTACYCLIN (PG I_2) AND PROSTAGLANDIN E_1 (PG E_1) IN AWAKE STANDING SHEEP : Cardiovascular drugs (II) : FREE COMMUNICATIONS (Abstract) : 45 Annual Scientific Meeting, Japanese Circulation Society
- Improvements in Thoracic Movement Following Lung Volume Reduction Surgery in Patients with Severe Emphysema
- Urinary incontinence in men with chronic obstructive pulmonary disease
- Malignant Hepatic Epithelioid Hemangioendothelioma with Rapid Progression and Fatal Outcome
- Results of a preliminary study using hypofractionated involved-field radiation therapy and concurrent carboplatin/paclitaxel in the treatment of locally advanced non-small-cell lung cancer
- PE-438 Role of Pravastatin in Preventing and Reversing Monocrotaline-induced Pulmonary Arterial Hypertension in Rats(Pulmonary Circulation 3 (H) : PE74)(Poster Session (English))
- Exogenous surfactant instillation attenuates inflammatory response to acid-induced lung injury in rat
- Gradual Progression of Interstitial Pneumonia Induced by Bepridil
- Progressive pulmonary calcification after successful renal transplantation
- Successful endoscopic dilatation to alleviate airway suffocation in a case with esophageal cancer after stent implantation
- Thymic Squamous Cell Carcinoma Producing Parathyroid Hormone-related Protein and CYFRA 21-1
- Successful Salvage Therapy of Irinotecan for Relapsed Hodgkin's Lymphoma
- Lung Tissue Distribution After Intravenous Administration of Grepafloxacin : Comparative Study With Levofloxacin
- Rhabdomyolysis Triggered by an Asthmatic Attack in a Patient with McArdle Disease
- OJ-394 A Comparison of the Strain Doppler Echocardiographic Features of Familial Amyloid Polyneuropathy (FAP) and Primary (AL) Amyloidosis(Echo/Doppler 14 (I) : OJ48)(Oral Presentation (Japanese))
- Bronchoscopic Microsampling for Bacterial Colony Counting in Relevant Lesions in Patients with Pulmonary Mycobacterium avium Complex Infection
- Pravastatin Improves Monocrotaline-Induced Pulmonary Hypertension and Prolongs Survival in Rats Independent of Its Cholesterol Lowering Action
- Nonspecific Interstitial Pneumonia Associated with Collagen Vascular Disease: Analysis of CT Features to Distinguish the Various Types
- A Rare Case of a Tracheal Fibroepithelial Polyp Treated by an Endobronchial Resection
- Pleomorphic Adenoma with an Endobronchial Resection
- Chromium (VI) inhibits mouse metallothionein-I gene transcription by modifying the transcription potential of the co-activator p300
- Colonic Sarcoidosis Presenting Multiple Submucosal Tumor-Like Lesions
- Identification of asymmetrically localized transcripts along the animal-vegetal axis of the Xenopus egg
- Phase II study of carboplatin and gemcitabine as adjuvant chemotherapy in patients with completely resected non-small cell lung cancer : a report from the Central Japan Lung Study Group, CJLSG 0503 trial
- Pericardial hemangioma presenting fetal cardiac tamponade and postnatal bronchostenosis
- Nocturnal Oxygen Desaturation as a Predictive Risk Factor for Coronary Restenosis After Coronary Intervention : Serial Quantitative Coronary Angiography Study
- SHORT-TERM OUTCOMES OF ENDOSCOPIC SUBMUCOSAL DISSECTION (ESD) FOR EARLY GASTRIC NEOPLASM : MULTICENTER SURVEY BY OSAKA UNIVERSITY ESD STUDY GROUP
- Development of the quadruped walking robot, TITAN-IX : mechanical design concept and application for the humanitarian de-mining robot
- Walking robot for humanitarian demining
- Effects of Muscle Relaxation Therapy Using Specially Designed Plates in Patients with Pulmonary Emphysema
- A case of severe mitral regurgitation without cardiac symptoms
- Orientational Transition of P-pentyl-p'-cyano- biphenyls Triggered by Conformational Change of Surface Azobenzene Monolayer
- MOLECULAR IDENTIFICATIONS OF THREE ISOFORMS OF PPARS (PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS) IN THE LEOPARD GECKO, Eublepharis macularius
- Improvements in Quadriceps Force and Work Efficiency are Related to Improvements in Endurance Capacity Following Pulmonary Rehabilitation in COPD Patients
- A Case of Organizing Pneumonia Induced by Tocilizumab
- Combination Chemotherapy with Doxorubicin, Vincristine, Cyclophosphamide, and Platinum Compounds for Advanced Thymic Carcinoma
- Synchronous Gastrointestinal Stromal Tumor and Primary Lung Adenocarcinoma
- Myocardial Performance Index in Subjects Susceptible to High-Altitude Pulmonary Edema
- Predictors of the Need to Initiate Noninvasive Ventilation in Stable Outpatients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease
- Acute Lung Injury with Alveolar Hemorrhage Due to a Novel Swine-Origin Influenza A (H1N1) Virus
- IgG4-Related Airway Involvement Which Developed in a Patient Receiving Corticosteroid Therapy for Autoimmune Pancreatitis
- Acute Lung Injury Review
- Noninvasive Ventilation in Patients with Acute Exacerbation of Pulmonary Tuberculosis Sequelae
- Mediastinal Seminoma in a Patient with Multiple Endocrine Neoplasia Type 1
- Mechanical Ventilation in Patients with Hypoxemia due to Refractory Heart Failure
- Primary Malignant Sarcomatoid Mesothelioma in the Pericardium
- Lymphoid Interstitial Pneumonia Associated with Common Variable Immunoglobulin Deficiency
- IgG4-associated Multifocal Systemic Fibrosis Complicating Sclerosing Sialadenitis, Hypophysitis, and Retroperitoneal Fibrosis, but Lacking Pancreatic Involvement
- Oropharyngeal Metastasis of Cardiogenic Angiosarcoma
- Combination Therapies Targeting Multiple Pathways in idiopathic pulmonary fibrosis (IPF)
- Late-onset Rejection of a Unilateral Donor Lung with Vascular C4d Deposition in Bilateral Living-donor Lobar Lung Transplantation: An Autopsy Case Report