Function of Metallothionein in Gene Expression and Signal Transduction : Newly Found Protective Role of Metallothionein
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概要
- 論文の詳細を見る
A heavy-metal-binding protein, metallothionein (MT), is induced by heavy metal overload and reactive oxygen species (ROS). The metals and ROS are rendered harmless by binding to MT or by oxidizing MT, respectively. This is a well-known role of MT. MT is also induced by glucocorticoids and cytokines. Induced MT may increase intracellular free zinc and modulate the activity of transcription factors. Changes in MT levels are thought to help in adaptation to changes in environmental conditions. MT modulates inflammatory reactions, including lipopolysaccharide (LPS)-induced expression of cytokines, nitric oxide production from macrophages in response to LPS, and resistance to LPS/D-galactosamine-induced lethality. In this review, we focus on a newly found protective role of MT, which acts mainly via changes in intracellular zinc levels or modulation of gene expression.
- 社団法人日本薬学会の論文
- 2008-06-01
著者
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Itoh Norio
Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka Unive
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Kimura Tomoki
Department of Toxicology, Faculty of Pharmaceutical Sciences, Setsunan University
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Itoh Norio
Department Of Toxicology Graduate School Of Pharmaceutical Sciences Osaka University
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Kimura Tomoki
Dep. Of Toxicology Fac. Of Pharmaceutical Sciences Setsunan Univ.
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Kimura Tomoki
Department Of Radiology Kagawa University
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Kimura Tomoki
Department Of Radiation Oncology Hiroshima University Graduate School Of Biomedical Sciences
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Itoh Norio
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kobe-Gakuin University
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