Polymyxin B-immobilized Fiber Column Hemoperfusion Treatment for Drug-Induced Severe Respiratory Failure: Report of Three Cases

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概要

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• The effects of direct hemoperfusion with polymyxin B-immobilized fiber (PMX-DHP) treatment for acute exacerbation of interstitial pneumonia have been reported. Here, we report 3 severe cases of drug-induced interstitial lung disease (DI-ILD) that were treated with PMX-DHP. Two DI-ILD cases were caused by methotrexate, and the third case was caused by the herbal medicine sanmotsu-ogon-to. The arterial oxygen tension/inspiratory oxygen fraction ratio improved during PMX-DHP treatment in all 3 patients. Finally, 2 patients survived and 1 died. The study findings indicate that PMX-DHP treatment is a viable option for the management of acute respiratory failure in patients with DI-ILD.

著者

• Kubo Keishi

  The First Department of Internal Medicine, Shinshu University School of Medicine

• Yokoyama Toshiki

  The First Department of Internal Medicine, Shinshu University School of Medicine

• Kubo Keishi

  The First Department Of Internal Medicine Shinshu University

• Tsushima Kenji

  The First Department Of Internal Medicine Shinshu University School Of Medicine

• Yamamoto Hiroshi

  The First Department Of Internal Medicine Kobe University School Of Medicine

• Agatsuma Toshihiko

  The First Department of Internal Medicine, Shinshu University School of Medicine

• Ito Michiko

  The First Department of Medicine, Shinshu University School of Medicine

• Kozumi Tomonobu

  The First Department of Internal Medicine, Shinshu University School of Medicine

• Yamamoto Hiroshi

  The First Department of Internal Medicine, Shinshu University School of Medicine

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