Increased isoprostane levels in oleic acid-induced lung injury
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概要
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The present study was performed to examine a role of oxidative stress in oleic acid-induced lung injury model. Fifteen anesthetized sheep were ventilated and instrumented with a lung lymph fistula and vascular catheters for blood gas analysis and measurement of isoprostanes (8-epi prostaglandin F2 alpha). Following stable baseline measurements, oleic acid (0.08 ml/kg) was administered and observed 4 h. Isoprostane was measured by gas chromatography mass spectrometry with the isotope dilution method. Isoprostane levels in plasma and lung lymph were significantly increased 2 h after oleic acid administration and then decreased at 4 h. The percent increases in isoprostane levels in plasma and lung lymph at 2 h were significantly correlated with deteriorated oxygenation at the same time point, respectively. These findings suggest that oxidative stress is involved in the pathogenesis of the pulmonary fat embolism-induced acute lung injury model in sheep and that the increase relates with the deteriorated oxygenation.
- ACADEMIC PRESS INC ELSEVIER SCIENCEの論文
- 2009-10-16
著者
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Koizumi Tomonobu
First Department Of Internal Medicine Shinshu University School Of Medicine
-
Kaneki Toshimichi
First Department Of Internal Medicine Shinshu University School Of Medicine
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Kumagai Toshiko
First Department Of Medicine Shinshu University School Of Medicine
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Tsushima Kenji
The First Department Of Internal Medicine Shinshu University School Of Medicine
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