Characteristics of Asthma Resistant to Moderate Dose Inhaled Corticosteroid Treatment on Bronchial Hyperresponsiveness

スポンサーリンク

概要

• 論文の詳細を見る

• Object: This study was performed to determine the clinical characteristics of asthmatics with bronchial hyperresponsiveness (BHR) that could not be normalized by 6 months of treatment with a moderate dose of an inhaled corticosteroid (ICS). Methods: Thirty-four symptomatic patients with mild to moderate asthma, who had never received any ICS, were treated with 200 μg of inhaled fluticasone propionate twice a day for 6 months. Spirometry, BHR to methacholine, exhaled nitric oxide (NO) and eosinophils in induced sputum were examined before and 2 and 6 months after beginning treatment. Results: FEV1 was increased and bronchial responsiveness, exhaled NO and sputum eosinophilia were significantly decreased 2 and 6 months after starting ICS treatment. Bronchial responsiveness was further decreased at 6 months together with a further increase in FEV1. In 13 patients, BHR was not normalized despite the 6 months of treatment. This group showed a higher prevalence of males, those with a smoking history and airflow limitation, a higher eosinophil count in the sputum following 6 months of treatment and a longer history of asthma. Multiple, stepwise, linear regression analysis showed that sputum eosinophilia and lower FEV1/FVC following 6 months of treatment and a longer history of asthma were significant independent determinants for BHR after 6 months of ICS treatment. Conclusions: These findings suggest that the resistance to a moderate dose of ICS for BHR in asthmatics may be significantly associated with remained airflow limitation, eosinophilic airway inflammation resistive to moderate dose of ICS, and delayed introduction of ICS therapy.

• 社団法人 日本内科学会の論文

著者

• HANAOKA Masayuki

  First Department of Internal Medicine, Shinshu University School of Medicine

• Kubo Keishi

  First Department Of Internal Medicine Dhinshu University School Of Medicine

• YAMAGUCHI Shinji

  First Department of Internal Medicine, Shinshu University School of Medicine

• FUJIMOTO Keisaku

  First Department of Internal Medicine, Shinshu University School of Medicine

• Yamaguchi Shinji

  First Department Of Internal Medicine Shinshu University School Of Medicine

• Koizumi Tomonobu

  First Department Of Internal Medicine Shinshu University School Of Medicine

• Honda Takayuki

  Department Of Industrial Chemistry School Of Science And Technology Meiji University

• Urushibata Kazuhisa

  First Department of Internal Medicine, Shinshu University School of Medicine

関連論文

• Hemorrhagic rectal ulcer caused by a deformity of the coccyx complicated by normal delivery
• Effects of a synthetic protease inhibitor (gabexate mesilate) and a neutrophil elastase inhibitor (sivelestat sodium) on acid-induced lung injury in rats
• 腎癌に対するインターフェロンα療法中に完全房室ブロック,胸水貯留および間質性肺炎を生じた1例
• 小児悪性腫瘍患者由来α溶連菌における高頻度の meropenem 耐性
• S1-3 Role of gland mucous cell-type mucin in the gastric mucosa infected with Helicobacter pylori(THE 45TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
• Utility of Single-slice High-resolution CT in Upper Lung Field Combined with Low-dose Spiral CT for Lung-cancer Screening in the Detection of Emphysema
• Acute Eosinophilic Pneumonia Associated with Smoke from Fireworks
• Acute Hypoxic Pulmonary Vascular Response Does Not Accompany Plasma Endothelin-1 Elevation in Subjects Susceptible to High Altitude Pulmonary Edema
• Effect of Prone Position on Apnea Severity in Obstructive Sleep Apnea
• Familial 14-Mb deletion at 21q11.2-q21.3 and variable phenotypic expression
• Adult Langerhans Cell Histiocytosis with Independently Relapsing Lung and Liver Lesions That was Successfully Treated with Etoposide
• Catamenial Hemoptysis
• Two Cases of Severe Bronchiectasis Successfully Treated with a Prolonged Course of Trimethoprim/Sulfamethoxazole
• Carbohydrate Histochemistry of the Apical Membranes of Non-ciliated Bronchiolar Cells and Type II Pneumocytes in Six Mammalian Species
• Cardiovascular responses to high-frequency oscillatory ventilation during acute lung injury in sheep
• Pulmonary Embolism due to Right Ventricular Thrombus in a Case of Behcet's Disease
• Digital Tomosynthesis Imaging of the Lung
• Immunoblastic lymphadenopathy-like T-cell lymphoma complicated by multiple gastrointestinal involvement
• Churg-Strauss syndrome (allergic granulomatous angitis) presenting with ileus caused by ischemic ileal ulcer
• Elevated Serum CA19-9 Level and Regional Lymphadenopathy in a Young Man with Allergic Bronchopulmonary Aspergillosis
• IL-5 Predominant in Bronchoalveolar Lavage Fluid and Peripheral Blood in a Patient with Acute Eosinophilic Pneumonia
• Trends Over the Last 20 Years in the Clinical Background of Young Japanese Patients With Coronary Artery Disease
• Percutaneous Cardiopulmonary Support Aids Resuscitation From Sustained Ventricular Tachycardia
• Selective IgM Deficiency Accompanied with IgG4 Deficiency, Dermal Complications and a Bronchial Polyp
• Double cancer (Iung and colon cancer) that showed complete remission with irinotecan and cisplatin combined chemotherapy
• Distinct clinicopathological entity 'autoimmune pancreatitis-associated sclerosing cholangitis'
• Risk Factors for Hospital-acquired Bacteremia
• PJ-345 Predictive Value of β-methyliodophenylpentadecanoic Acid Scintigraphy on Long-term (Over 5 years) Clinical Outcome in Dilated Cardiomyopathy Patients Treated with β-blockade(Nuclear Cardiology 10 (I) : PJ58)(Poster Session (Japanese))
• Lymphoscintigraphy using technetium-99m HSA-DTPA with SPECT/CT in chylothorax after childbirth
• Large cell carcinoma of the lung with a rhabdoid phenotype
• Effect of β-Blockade on Pulmonary Iodine-123 Metaiodobenzylguanidine Uptake in Dilated Cardiomyopathy : Association with a Future Cardiac Event and Reverse Remodeling
• Clinical Utility of Combined Assessment of Lung and Heart Iodine-123 Metaiodobenzylguanidine Uptake in Patients with Chronic Heart Failure
• Study of a Naturally Drying Lacquer Hybridized with Organic Silane
• Clinical Characteristics and Outcome in Patients with Cardiac Sarcoidosis Mimicking Hypertrophic Cardiomyopathy : Does It Really Mimic Hypertrophic Cardiomyopathy?
• Long-Term Echocardiographic Follow-Up in Patients with Cardiac Sarcoidosis : Impact of Microangiopathy on Ventricular Remodeling and Outcome
• Prognostic Importance of Interventricular Conduction Delay in Dilated Cardiomyopathy Patients Treated with β-Blocker and Angiotensin Converting Enzyme Inhibitor
• Clinical Features and Prognosis of Cardiac Sarcoidosis Presenting as Unexplained Heart Failure and Cardiomyopathies
• Vagal Stimulation Prior to Atrial Rapid Pacing Protects the Atrium From Electrical Remodeling in Anesthetized Dogs
• Eradication of Helicobacter pylori decreases mucosal alterations linked to gastric carcinogenesis in Mongolian gerbils
• Successful Resection of Intracardiac Invasive Thymoma with Right Ventricular Inflow Tract Occlusion
• A case of primary follicular lymphoma of the duodenum with BCL-2 gene rearrangement
• Biventricular Hypertrophic Cardiomyopathy With Right Ventricular Outflow Tract Obstruction Associated With Noonan Syndrome in an Adult
• Application of Mucin Histochemistry for Pathological Diagnosis : Expression of Gastric Phenotypes in Metaplastic and Neoplastic Lesions and its Relation to the Organoid Differentiation
• Exogenous surfactant instillation attenuates inflammatory response to acid-induced lung injury in rat
• Gradual Progression of Interstitial Pneumonia Induced by Bepridil
• Progressive pulmonary calcification after successful renal transplantation
• Successful endoscopic dilatation to alleviate airway suffocation in a case with esophageal cancer after stent implantation
• Thymic Squamous Cell Carcinoma Producing Parathyroid Hormone-related Protein and CYFRA 21-1
• Successful Salvage Therapy of Irinotecan for Relapsed Hodgkin's Lymphoma
• Lung Tissue Distribution After Intravenous Administration of Grepafloxacin : Comparative Study With Levofloxacin
• Survey on Negative Impact of Chironomid Midges (Diptera) on Bronchial Asthmatic Patients in a Hyper-eutrophic Lake Area in Japan
• Histo- and Cytochemistry of Gland Mucus Cell Type Mucin and Its Practical Application for Pathologic and Clinical Diagnosis
• Ultrastructural Demonstration of Anionic Sites in the Basement Membrane of the Human Alveolar Type I Pneumocyte
• Small-intestinal sarcomatoid carcinoma with superior vena cava syndrome
• PJ-041 Association between Abnormal Myocardial Fatty Acid Metabolism and Interventricular Conduction Delay in Patients with Dilated Cardiomyopathy(Nuclear Cardiology 3 (I) : PJ7)(Poster Session (Japanese))
• A Small Peripheral Lung Cancer Engulfing A High-Resolution CT and MR Appearances
• Rhabdomyolysis Triggered by an Asthmatic Attack in a Patient with McArdle Disease
• Combined Protein C and Protein S Deficiency in a Family with Repetitive Thromboembolism and Segregated Gene Mutations
• Autoimmune pancreatitis-associated prostatitis : Distinct clinicopathological entity
• OJ-052 Effect of Mycophenolate Mofetil on Experimental Autoimmune Myocarditis in Rat Through Suppression of Osteopontin Expression(Myocarditis, Basic/Clinical (M) : OJ7)(Oral Presentation (Japanese))
• Combined Protein C and Protein S Deficiency in a Family with Repetitive Thromboembolism and Segregated Gene Mutations
• Lectin Histochemical Study of Squamous Carcinoma in the Head and Neck Region
• Increased isoprostane levels in oleic acid-induced lung injury
• Phase II Trial of Biweekly Paclitaxel and Gemcitabine as Second-Line Chemotherapy for Non-Small Cell Lung Cancer Previously Treated with Platinum-Based Chemotherapy
• Waldenstrom Macroglobulinemia Transforming from t(11;18)(q21;q21)-Negative Gastric MALT Lymphoma after Systemic Dissemination
• Isolation and Molecular Characterization of Catalase-Negative Staphylococcus aureus from Sputum of a Patient with Aspiration Pneumonia
• A Critical Increase in Right-to-Left Shunt After Acute Myocardial Infarction in a 68-year-old Male With Tetralogy of Fallot
• Characteristics of Asthma Resistant to Moderate Dose Inhaled Corticosteroid Treatment on Bronchial Hyperresponsiveness
• Hypersensitivity Pneumonitis Induced by Spores of Penicillium citrinum in a Worker Cultivating Enoki Mushroom
• Congenital Solitary Kidney With Renovascular Hypertension Diagnosed by Means of Captopril-enhanced Renography and Magnetic Resonance Angiography
• Lymphoid Interstitial Pneumonia Associated with Common Variable Immunoglobulin Deficiency
• Angiosarcoma with Sacral Origin Metastasizing to the Lung
• A Case of Acute Rheumatic Fever Accompanied by Transient Aortic Regurgitation.
• Laryngo-Tracheo-Bronchial Amyloidosis Presenting Severe Airway Stenosis
• Small-Cell Lung Carcinoma Produces Salivary-Type Amylase: A Case Report with Review
• Regulation of Body Weight by Leptin, with Special Reference to Hypoxia-induced Regulation

もっと見る 閉じる

スポンサーリンク