Vagal Stimulation Prior to Atrial Rapid Pacing Protects the Atrium From Electrical Remodeling in Anesthetized Dogs
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概要
- 論文の詳細を見る
Atrial electrical remodeling is thought to be the cause of the maintenance of atrial fibrillation(AF). Although the initiation and maintenance of AF is partially associated with autonomic nervous tone, vagally mediated AF does not tend to become permanent. Therefore, the effects of preceding vagal stimulation(VS)on the atrial effective refractory period(ERP)under electrical remodeling conditions were investigated in anesthetized dogs. Atrial ERPs were measured at 5 sites before and after a 7-h period of atrial rapid pacing in the control group. In the VS group, the vagus nerve was stimulated for 20 min before a period of atrial rapid pacing. Atrial rapid pacing shortened the ERP at each site in the control group(electrical remodeling). On the other hand, atrial rapid pacing after VS did not shorten the ERP at any site in the VS group. Tetrodotoxin, which was administered into the fatty tissue overlying the right atrial side of the right pulmonary vein junctions, blocked the protective effect of VS against the shortening of the ERP induced by atrial rapid pacing. In contrast, atropine did not interfere with such protective effects. These results suggest that VS prior to atrial rapid pacing protects the atrium from atrial electrical remodeling.
- 社団法人日本循環器学会の論文
- 2001-11-20
著者
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KUBO KEISHI
First Department of Internal Medicine, Shinshu University School of Medicine
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Kubo Keishi
First Department Of Internal Medicine Dhinshu University School Of Medicine
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Kiyosawa Kendo
Second Department Of Internal Medicine Shinshu University School Of Medicine
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Owa Mafumi
First Department of Internal Medicine, Shinshu University School of Medicine
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Owa Mafumi
First Department Of Internal Medicine Shinshu University School Of Medicine
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Usui Tatsuya
Second Department Of Internal Medicine Shinshu University School Of Medicine
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Tsuboi Masato
Second Department Of Internal Medicine Shinshu University School Of Medicine
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Takei Manabu
Second Department of Internal Medicine, Shinshu University School of Medicine
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Hanaoka Takeshi
Second Department of Internal Medicine, Shinshu University School of Medicine
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Kurogouchi Fumio
Second Department of Internal Medicine, Shinshu University School of Medicine
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Aruga Masakazu
Second Department of Internal Medicine, Shinshu University School of Medicine
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Katagiri Yuuichi
Second Department of Internal Medicine, Shinshu University School of Medicine
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Takei Manabu
Second Department Of Internal Medicine Shinshu University School Of Medicine
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Aruga Masakazu
Second Department Of Internal Medicine Shinshu University School Of Medicine
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Katagiri Yuuichi
Second Department Of Internal Medicine Shinshu University School Of Medicine
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Kurogouchi Fumio
Second Department Of Internal Medicine Shinshu University School Of Medicine
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Hanaoka Takeshi
Second Department Of Internal Medicine Shinshu University School Of Medicine
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