Lung Tissue Distribution After Intravenous Administration of Grepafloxacin : Comparative Study With Levofloxacin

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概要

• 論文の詳細を見る

• The aim of the present study is to study the pharmacokinetics in plasma, lung lymph and bronchial washing fluid after intravenous infusion of grepafloxacin (GPFX), in comparison with those of levofloxacin (LVFX). Four conscious sheep with chronically instrumented lung lymph fistulas and tracheotomy were prepared. GPFX and LVFX concentrations in plasma and lung lymph after intravenous infusion of the drugs (10 mg/kg) for over 10 min were measured. In addition serial bronchial washing with 50 mL normal saline was performed to obtain epithelial lining fluid (ELF) at 2, 4, 6, 8, 12, 24 h after the intravenous administration. The time courses of lung lymph concentration were almost identical to those of the concomitant levels of both GPFX and LVFX in plasma, suggesting that both GPFX and LVFX could be easily moved from plasma to pulmonary interstitium and/or lung lymph circulation. However, GPFX concentrations of ELF were significantly higher than LVFX concentrations over time after the administration. In addition, intracellular concentrations in ELF of GPFX were also extremely high compared with those of LVFX. These results demonstrated that penetration of GPFX in bronchial wall, bronchial epithelium and/or phagocytic cells was superior to that of LVFX. These observations suggest that the pharmacokinetic characteristics of GPFX in the lung may provide a new insight into the strategy for clinical treatment of various pulmonary infections, especially cytotropic bacterial infections.

• 社団法人 日本薬理学会の論文
• 2002-01-01

著者

• KOIZUMI TOMONOBU

  First Department of Internal Medicine, Shinshu University School of Medicine

• KUBO KEISHI

  First Department of Internal Medicine, Shinshu University School of Medicine

• Kubo Keishi

  First Department Of Internal Medicine Dhinshu University School Of Medicine

• Hirota Masao

  Department Of Drug Metabolism Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd

• Kubo Keishi

  The Department Of Neurology Nagano Red Cross Hospital

• KANEKI Toshimichi

  First Department of Internal Medicine, Shinshu University School of Medicine

• FUJIMOTO Keisaku

  First Department of Internal Medicine, Shinshu University School of Medicine

• Koizumi Tomonobu

  First Department Of Internal Medicine Shinshu University School Of Medicine

• Kaneki Toshimichi

  First Department Of Internal Medicine Shinshu University School Of Medicine

• Yamamoto Hiroshi

  First Depatment Of Internal Medicine Kobe University School Of Medicine

• Kubo Keishi

  The First Department Of Internal Medicine Shinshu University Hospital

• OGASAWARA Hitoshi

  First Department of Internal Medicine, Shinshu University School of Medicine

• YAMAZAKI Yoshitaka

  First Department of Internal Medicine, Shinshu University School of Medicine

• Yamamoto H

  Department Of Orthopaedic Surgery Nara Medical University

• Kumagai Toshiko

  First Department Of Medicine Shinshu University School Of Medicine

• Ogasawara Hitoshi

  First Department Of Internal Medicine Shinshu University School Of Medicine

• Yamamoto H

  Ibaraki Univ. Mito

• Kubo Keishi

  The First Department Of Internal Medicine Shinshu University

• Tsushima Kenji

  The First Department Of Internal Medicine Shinshu University School Of Medicine

• Yamazaki Yoshitaka

  Department Of Endoscopy Shinshu University Hospital

• Yamamoto Hiroshi

  Okayama Univ. Okayama Jpn

• Yamamoto Hiroshi

  First Department Of Surgery Asahikawa Medical College

• Kubo K

  Department Of Pulmonary And Infectious Diseases Shinshu University Hospital

• Yamamoto Hiroshi

  First Department of Internal Medicine, Shinshu University School of Medicine

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