EFFECTS OF PROSTACYCLIN (PGI_2) ON HYPOZICPULMONARY VASOCONSTRICTION IN THE CONSCIOUS ADULT SHEEP

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The effects of prostacyclin (PGI_2) on alveolar hypoxic pulmonary vasoconstriction were investigated in the conscious adult sheep. In our model, hypoxia also produced increases in pulmonary arterial pressure (P_<PA) and pulmonary vascular resistance (PVR), indicating pulmonary vasoconstriction. PGI_2 was injected rapidly as a 0.5 μg/kg bolus via the right atrium in five sheep during normoxia and hypoxia. During normoxia, PGI_2 increased P_<PA> and cardiac output, and decreased systemic arterial pressure (P_<SA>), systemic vascular resistance (SVR) and PVR. Left atrial pressure did not change. During hypoxia following PGI_2 administration, P_<PA> decreased, CO increased, and PVR decreased, suggesting dilator action on the pulmonary resistance vessels. As the same time P_<SA> and SVR decreased, suggesting dilator action on the systemic resistance vessels. However, the degree of the decline in PVR caused by PGI_2 was much greater during hypoxia than during normoxia. The decreases in P_<SA> and SVR induced by PGI_2 were not significant between hypoxia and normoxia. These findings confirm that PGI_2 decreases pulmonary and systemic vascular resistances in normoxic and hypoxic sheep. Moreover, during hypoxia, associated with the increased P_<PA> and PVR, the administration of PGI_2 appears to be particularly effective in normalizing these parameters.
社団法人日本循環器学会の論文
1985-07-20