Angiotensin-Converting Enzyme Gene Polymorphisms and Prognosis in Chronic Thromboembolic Pulmonary Hypertension

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概要

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• Background Angiotensin-converting enzyme (ACE) plays an important role in vascular remodeling in pulmonary hypertension, and ACE gene polymorphism is associated with exercise-induced pulmonary hypertension in Japanese patients with chronic obstructive pulmonary disease. The present study was designed to investigate if ACE-insertion (I)/deletion (D) polymorphism might be related to the susceptibility, severity, and disease out-come in chronic thromboembolic pulmonary hypertension (CTEPH). Methods and Results ACE-I/D genotypes were determined in 95 consecutive CTEPH patients (46 underwent surgery, 49 received medical treatment) and 97 controls. The frequencies of genotypes and alleles were not significantly different between patients and controls. Clinical characteristics were compared among ACE genotypes (II, ID, DD). ACE D allele carrier (ID plus DD) was associated with a lower 6-min walk test distance compared with D allele non-carrier (II) (330±102 (mean±SD) vs 381±85m, p=0.046). Kaplan-Meier analysis in the medically treated group showed significantly deteriorated survival for D allele carriers compared with D allele non-carriers (p=0.0389). Multivariate analysis revealed that age (p=0.013), pulmonary vascular resistance (p=0.008), and D allele carrier status (p=0.021) were independent predictors of survival. Conclusion ACE D allele carrier is possibly one of the prognostic factors for medically treated CTEPH patients.

• 社団法人日本循環器学会の論文
• 2006-08-20

著者

• 田中 紘一

  Research Reactor Institute Kyoto University

• Kasahara Yasunori

  Department of Respirology, Graduate School of Medicine, Chiba University

• Tatsumi Koichiro

  Department of Respirology, Graduate School of Medicine, Chiba University

• Komura S

  1st Department Of Internal Medicine Niigata University School Of Medicine

• Tanaka Nobuhiro

  Department Of Respirology Graduate School Of Medicine Chiba University

• Kuriyama Takayuki

  Department of Chest Medicine, School of Medicine, Chiba University

• 小林 敏雄

  自動車研

• Tanabe Nobuhiro

  The Japanese Society Of Pulmonary Embolism Research

• Tanabe Nobuhiro

  Department Of Respirology Chiba Graduate School Of Medicine

• Matsubara Hiroshi

  Department of Respirology, Graduate School of Medicine, Chiba University

• Takiguchi Yuichi

  Department of Respirology, Graduate School of Medicine, Chiba University

• TAKIGUTI Yuichi

  School Med. Chiba Univ.

• KURIYAMA Takayuki

  School Med. Chiba Univ.

• Takiguchi Yuichi

  Department Of Respirology Graduate School Of Medicine Chiba University

• Kuriyama Takayuki

  The Japanese Society of Pulmonary Embolism Research

• 田中 紘一

  長岡技術科学大学 工学部機械系

• Kawata Takayuki

  Department Of Respirology Graduate School Of Medicine Chiba University

• Amano Shinya

  Department of Respirology, Graduate School of Medicine, Chiba University

• Kominami Satoshi

  Department of Respirology, Graduate School of Medicine, Chiba University

• Igarashi Natsuhiko

  Department of Respirology, Graduate School of Medicine, Chiba University

• Shimura Ryuhi

  Department of Respirology, Graduate School of Medicine, Chiba University

• Kuriyama Takayuki

  Department Of Respirology Graduate School Of Medicine Chiba University

• Kuriyama Takayuki

  Department Of Respirology Chiba University Graduate School Of Medicine

• Kubota Tomoko

  Department of Clinical Pharmacology and Pharmacogenomics

• Matsubara Hiroshi

  Department Of Dermatology Graduate School Of Medicine Chiba University

• Yamaguchi Tetsuo

  Department Of Respiratory Medicine Jr Tokyo General Hospital East Japan Railway

• Amano Shinya

  Department Of Respirology Graduate School Of Medicine Chiba University

• Kuriyama Takayuki

  Department Of Respirology Chiba Graduate School Of Medicine

• Shimura Ryuhi

  Department Of Respirology Graduate School Of Medicine Chiba University

• Tanabe Nobuhiro

  Department Of Chemistry Faculty Of Science Kyoto University

• Kawata Takayuki

  Department Of Cardiovascular Science And Medicine Chiba University Graduate School Of Medicine

• Takiguti Yuichi

  Department Of Respirology Graduate School Of Medicine Chiba University

• Kuriyama Takayuki

  Department Of Cardiovascular Science And Medicine Chiba University Graduate School Of Medicine

• Kominami Satoshi

  Department Of Respirology Graduate School Of Medicine Chiba University

• Igarashi Natsuhiko

  Department Of Respirology Graduate School Of Medicine Chiba University

• Tatsumi Koichiro

  Department Of Chest Medicine School Of Medicine Chiba University

• Takiguchi Yuichi

  Department Of Pulmonary Medicine Graduate School Of Medicine Chiba University

• Tatsumi Koichiro

  Department Of Respirology (b2) Graduate School Of Medicine Chiba University

• Takiguchi Yuichi

  Department Of Chemotherapy Graduate School Of Medicine Chiba University

• Kasahara Yasunori

  Department Of Respirology Graduate School Of Medicine Chiba University

• Matsubara Hiroshi

  Department Of Biology Faculty Of Science Osaka University

• Matsubara Hiroshi

  Department Of Respirology Graduate School Of Medicine Chiba University

• Matsubara Hiroshi

  Deparlment Of Internal Medicine School Of Medicine Kyoto University

• Takiguti Yuichi

  Department Of Pulmonary Medicine Graduate School Of Medicine Chiba University

• Kuriyama Takayasu

  Department Of Respirology Chiba Graduate School Of Medicine

• Kominami Satoshi

  Department Of Respiratology Graduate School Of Medicine Chiba University

• Kasahara Yasunori

  Department of Respirology (B2), Graduate School of Medicine, Chiba University, Japan

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