Antiparkinsonian Drugs and Their Neuroprotective Effects
スポンサーリンク
概要
- 論文の詳細を見る
In Parkinson's disease, while dopamine (DA) replacement therapy, such as with L-DOPA (levodopa), improves the symptoms, it does not inhibit the degeneration of DA neurons in the substantia nigra. Numerous studies have suggested that both endogenous and environmental neurotoxins and oxidative stress may participate in this disease, but the detailed mechanisms are still unclear. Recent genetic studies in familial Parkinson's disease and parkinsonism have shown several gene mutations. This new information regarding its pathogenesis offers novel prospects for effective strategies involving the neuroprotection of vulnerable DA neurons. This review summarizes current findings regarding the pathogenesis and antiparkinsonian drugs, and discusses their possibilities of targets to develop novel neuroprotective drugs.
- 公益社団法人日本薬学会の論文
- 2002-03-01
著者
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Taniguchi Takashi
Department of Geophysics, Faculty of Science, Hokkaido University
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KITAMURA Yoshihisa
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
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Kondo Jun-ichi
Department Of Neurobiology Kyoto Pharmaceutical University
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KAKIMURA Jun-ichi
Department of Neurobiology, Kyoto Pharmaceutical University
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Kakimura Jun-ichi
Department Of Neurophysiology Graduate School Of Biomedical Sciences Hiroshima University
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Kakimura Jun-ichi
Department Of Neurobiology Kyoto Pharmaceutical University
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Kanai Yoshihito
Department Of Pharmaceutical Care And Health Sciences Okayama University Graduate School Of Medicine
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Kitamura Yoshihisa
Department Of Neurobiology Kyoto Pharmaceutical University
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Kitamura Yoshihisa
Department Of Pharmacology Research Institute For Wakan-yaku Toyama Medical And Pharmaceutical Unive
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Kitamura Y
Department Of Neurobiology Kyoto Pharmaceutical University
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Taniguchi T
Kek Ibaraki‐ken Jpn
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Taniguchi Takashi
Department Of Geophysics Faculty Of Science Hokkaido University
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Taniguchi Takashi
Department Of Dermatology Faculty Of Medicine University Of Tokyo
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TANIGUCHI Takashi
Department of Computational Science and Engineering, Nagoya University
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Kitamura Yoshihisa
Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Japan
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Taniguchi Takashi
Department of Biology, Kyoto Pharmaceutical University
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KITAMURA Yoshihisa
Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
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