Use-Dependent Removal of the 4-Aminopyridine-Induced Block of the Transient K^+ Current in Rat Dorsal Root Ganglia
スポンサーリンク
概要
- 論文の詳細を見る
Effects of 4-aminopyridine (4-AP) on the transient K+ current (IA) was studied in rat sensory neurons using the whole cell patch-clamp technique. The amplitude of IA was reduced by 4-AP. The steady-state inactivation curve for IA was shifted in the positive direction by 4-AP, suggesting that the blocking action of 4-AP may be attenuated by membrane depolarization. When two IAs were evoked with variable intervals, the peak amplitude of the IA induced by the second pulse was augmented in the presence of 4-AP. These results indicate that the action of 4-AP can be modulated by concurrent neuronal activities.
- 社団法人 日本薬理学会の論文
- 2003-07-01
著者
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MARUYAMA Hiroshi
Department of Pathology, Hoshigaoka Koseinenkin Hospital
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OGATA Nobukuni
Department of Neurophysiology, Graduate School of Biomedical Sciences, Hiroshima University
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Kondo Jun-ichi
Department Of Neurobiology Kyoto Pharmaceutical University
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OHNISHI YOSHIAKI
Department of Emergency and Critical Care Medicine, Tokushima University Hospital
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Kakimura Jun-ichi
Department Of Neurophysiology Graduate School Of Biomedical Sciences Hiroshima University
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Ogata Nobukuni
Department Of Neurophysiology Graduate School Of Biomedical Sciences Hiroshima University
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Maruyama Hiroshi
Department Of General Thoracic Surgery Juntendo University
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ZHENG Taixing
Department of Neurophysiology, Graduate School of Biomedical Sciences, Hiroshima University
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MATSUTOMI Tomoya
Department of Neurophysiology, Graduate School of Biomedical Sciences, Hiroshima University
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KAKIMURA Jun
Department of Neurophysiology, Graduate School of Biomedical Sciences, Hiroshima University
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Zheng Taixing
Department Of Neurophysiology Graduate School Of Biomedical Sciences Hiroshima University
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Ohnishi Yoshiaki
Department Of Neurophysiology Graduate School Of Biomedical Sciences Hiroshima University
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Ohnishi Yoshiaki
Department Of Emergency And Critical Care Medicine Tokushima University Hospital
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Matsutomi Tomoya
Department Of Neurophysiology Graduate School Of Biomedical Sciences Hiroshima University
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Maruyama Hiroshi
Department Of Neurophysiology Graduate School Of Biomedical Sciences Hiroshima University
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Ohishi Yoshiaki
Department Of Physiology Hiroshima University School Of Medicine
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Ohishi Yoshiaki
Department of Neurophysiology, Graduate School of Biomedical Sciences, Hiroshima University
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