Ultrastractural alterations of right and left ventricular myocytes in tetralogy of fallot.
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概要
- 論文の詳細を見る
We examined the ultrastructure of right and left ventricular myocardial biopsies obtaind prior to cardiopulmonary bypass in fourteen patients undergoing total correction of tetralogy of Fallot (TOF). Twelve patients were undergoing primary one-stage repair and two patients had had a previous Blalock-Taussig shunt operation. The ages of the patients ranged from 3 to 35 years. In left ventricular (LV) myocytes, the sarcolemma often formed pouches filled with mitochondria and the muscle fibers showed a disoriented arrangement. In addition, the myofibrils showed hypercontraction and the Z-bands were thickened; the degree of the myofibril contraction was more severe than that in right ventricular (RV) myocytes. These ultrastractural findings are similar to those observed in myocytes under hypoxic conditions. The number of lysosomes in LV myocytes, but not in RV myocyte increased in the older patients. While we have not established a causal relationship between the ultrastractural findings and clinical features in our cases, our observations are consistent with the possibilitv that early total correction of TOF may be required to prevent the development of hypoxic changes and degeneration of heart muscle.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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Ohishi Kiroku
Department Of 2nd Surgery Kurume University School Of Medicine
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Hisatomi Kouichi
Department of Surgery, Kurume University School of Medicine
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Kosuga Kenichi
Department Of 2nd Surgery Kurume University School Of Medicine
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Nishimi Masaru
Department Of Cardiovascular Surgery And Clinical Research Laboratory National Kyushu Medical Center
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Hayashida Nobuhiko
Department Of Surgery Kurume University School Of Medicine
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Isomura Tadashi
Department Of 2nd Surgery Kurume University School Of Medicine
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Maruyama Hiroshi
Department Of General Thoracic Surgery Juntendo University
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ISOMURA TADASHI
Department of Surgery, Kurume University School of Medicine
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NISHIMI MASARU
Department of Surgery, Kurume University School of Medicine
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INUZUKA HIROTO
Department of Surgery, Kurume University School of Medicine
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SUZUKI SHIGEMITSU
Department of Surgery, Kurume University School of Medicine
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KOGA MASAYUKI
Department of Surgery, Kurume University School of Medicine
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OHISHI KIROKU
Department of Surgery, Kurume University School of Medicine
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