Influence of Colforsin Daropate Hydrochloride on Internal Mammary Artery Grafts
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概要
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The effect of colforsin daropate hydrochloride (colforsin), a water-soluble forskolin derivative, on blood flow in internal mammary artery (IMA) grafts was evaluated in a prospective randomized study of 26 patients undergoing coronary artery bypass grafting. Patients were randomized to receive either colforsin treatment (colforsin; n=14) or no colforsin treatment (control; n=14). Administration of colforsin (0.5mg. kg^<-1>・min^<-1>) was started after induction of anesthesia and was continued for 6h. IMA blood flow and hemodynamic measurements were assessed perioperatively. During cardiopoulmonary bypass (CPB), perfusion flow was adjusted to 2.5 L/m^2 IMA free blood flow was measured. IMA blood flow was also measured 1h after CPB by an ultrasonic flow meter. Systemic vascular resistance was significantly lower in the colforsin group during and after CPB. IMA blood flow was significantly greater in the colforsin group than in the control group during (44±2 vs 33±3 ml min^<-1>・m^<-2>, p=0.02) and after CPB (38±6 vs 20±3 ml min^<-1> p=0.01). IMA blood flow 1h after CPB correlated inversely with concurrent systemic vascular resistance (r=-0.61, p=0.001). Intraoperative administration of colforsin daropate hydrochloride caused potent vasodilation, resulting in an increase in IMA blood flow. The results indicate that the regimen can be used perioperatively in patients undergoing coronary artery bypass grafting.
- 社団法人日本循環器学会の論文
- 2002-03-20
著者
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TAYAMA Eiki
Department of Cardiovascular Surgery, Kurume University School of Medicine
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AOYAGI Shigeaki
Department of Cardiovascular Surgery, Kurume University School of Medicine
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TESHIMA HIDEKI
Department of Cardiovascular Surgery, Omura Municipal Hospital, Cardiovascular Center
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Aoyagi Shigeaki
Department Of Surgery Kurume University School Of Medicine
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HAYASHIDA Nobuhiko
Department of Surgery, Kurume University School of Medicine
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Chihara Shingo
Department of Surgery, Kurume University
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Kawara Takemi
Department of Surgery, Kurume University
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Tayama Eiki
Department Of Cardiovascular Surgery Kurume University School Of Medicine
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Tayama Eiki
Department Of Cardiovascular Surgery Clinical Research Center Kyushu Medical Center National Hospita
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Enomoto Naofumi
Department of cardiovascular surgery, Our lady of snow st.mary's hospital
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Kawara Takemi
Department Of Surgery Kurume University School Of Medicine
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Teshima Hideki
The Department Of Surgery Kurume University School Of Medicine
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Teshima Hideki
Department Of Cardiovascular Surgery Omura Municipal Hospital Cardiovascular Center
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Chihara Shingo
Department Of Surgery Kurume University School Of Medicine
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Hayashida Nobuhiko
Department Of Surgery Kurume University School Of Medicine
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Enomoto Naofumi
Department Of Surgery Kurume University
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Enomoto Naofumi
Department Of Cardiovascular Surgery Our Lady Of Snow St.mary's Hospital
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Hayashida Nobuhiko
Second Department Of Surgery Kurume University Hospital
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Aoyagi Shigeaki
Dept. Of Iind Surgery Kurume Unrverslty School Of Medicine
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Aoyagi Shigeaki
Division Of Cardiovascular Surgery Department Of Surgery Kurume University School Of Medicine
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Enomoto Naofumi
Department Of Cardiovascular Surgery Munakata Suikokai General Hospital
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Kawara Takemi
Department Of Cardiovascular Surgery St. Mary's Hospital
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Teshima Hideki
Department Of Cardiovascular Surgery Clinical Research Institute National Hospital Organization Kyushu Medical Center
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