BENEFICIAL EFFECT OF THE ADDITION OF NITROGLYCERIN TO THE CARDIOPLEGIC SOLUTION ON THE COLD-STORED REPERFUSED ISOLATED RAT HEART
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概要
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We discuss here the effect of the addition of trinitroglycerin to the cardioplegic solution on the isolated rat heart after eight hours of storage. This effect was evaluated by measuring cardiac function as well as myocardial calcium and enzymes. Male Wistar rats were divided into three groups based on the concentration of trinitroglycerine in the cardioplegic solution. In the control group, the fluid used was a crystalloid cardioplegic solution (K^+ 25 mEq/L) without trinitroglycerin and for groups I and II, trinitroglycerin was added at concentrations of 2 μg/ml and 5 μg/ml, respectively. All hearts were arrested with the cardioplegic solution at 4℃ and then immersed for eight hours in Euro-Collins' solution at 4℃. The postperfusion coronary flow showed higher rates for groups I and II than for the control group (p<0.05), while the difference between groups I and II was not significant. In group I, the total concentrations of creatine kinase-MB, lactate and malondialdehyde after reperfusion showed the lowest levels; this group also had the lowest content of myocardial calcium. These results indicate that the addition of nitroglycerin, especially at a concentration of 2 μg/ml, to the cardioplegic solution elicits better cardiac function for immersed rat heart.
- 社団法人日本循環器学会の論文
- 1993-06-20
著者
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Isomura Tadashi
Second Department Of Surgery Kurume University Hospital
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Aoyagi Shigeaki
Department Of Surgery Kurume University School Of Medicine
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Ohishi Kiroku
Department Of 2nd Surgery Kurume University School Of Medicine
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Oishi Kiroku
The 2nd Department Of Surgery Kurume University School Of Medicine
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Ohishi Kiroku
The Second Department Of Surgery Kurume University Hospital
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Kosuga Kenichi
Second Department Of Surgery Kurume University Hospital
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HISATOMI KOUICHI
Second Department of Surgery, Kurume University School of Medicine
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OHISHI KIROKU
Second Department of Surgery, Kurume University School of Medicine
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MARUYAMA Hiroshi
Second Department of Internal Medicine, Saitama Medical Center, Saitama Medical School
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AOYAGI Shigeaki
Second Department of Surgery, Kurume University Hospital
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KOSUGA KEINICHI
Second Department of Surgery, Kurume University School of Medicine
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Hisatomi Kouichi
Second Department Of Surgery Kurume University Hospital
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Aoyagi Shigeaki
Second Department Of Sugery Kurume University School Of Medicine
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Aoyagi Shigeaki
Dept. Of Iind Surgery Kurume Unrverslty School Of Medicine
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Aoyagi Shigeaki
Division Of Cardiovascular Surgery Department Of Surgery Kurume University School Of Medicine
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Kosuga Kenichi
2nd Dept. Of Surg. Kurume Univ. School Of Med.
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Ooishi Kiroku
2nd Dept. Of Surg. Kurume Univ. School Of Med.
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Maruyama Hiroshi
Second Department Of Surgery Kurume University Hospital
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