Involvement of Voltage-Gated Sodium Channel Na_v1.8 in the Regulation of the Release and Synthesis of Substance P in Adult Mouse Dorsal Root Ganglion Neurons
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概要
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This study was conducted to determine whether Nav1.8 contributes to the release and/or synthesis of substance P (SP) in adult mice dorsal root ganglion (DRG) neurons. The SP released from cultured DRG neurons of Nav1.8 knock-out mice exposed to either capsaicin or KCl was significantly lower than that from wild-type (C57BL/6) mice based on a radioimmunoassay. The SP level of L6 DRG in Nav1.8 knock-out mice was also lower than that in wild-type mice. After chronic constriction injury (CCI) of the sciatic nerve, the level of SP decreased in the L6 ipsilateral DRG of wild-type but not Nav1.8 knock-out mice. The preprotachykinin-A (PPT-A) mRNAs in L4 – 6 DRGs of Nav1.8 knock-out mice also fell to half their normally abundant levels of expression. There were significant increases in Nav1.8 expression of the L6 contralateral DRG from wild-type mice and in the percentage of neurons expressing neurokinin-1 receptor in the cytosol of L6 DRGs from wild-type or Nav1.8 knock-out mice. These findings suggest that Nav1.8 is involved in the regulation of the release and synthesis of SP in the DRG neurons of wild-type mice.
- 社団法人 日本薬理学会の論文
- 2008-10-20
著者
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Tang He-bin
Department Of Pharmacology Graduate School Of Biomedical Sciences Hiroshima University
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Tang He-bin
Department Of Pharmacology Division Of Clinical Pharmaceutical Sciences Programs Of Pharmaceutical S
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Tang He-bin
広島大学 医歯薬学総合研究科薬効解析科学
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Tang He-bin
広島大学 医歯薬学総合研究科麻酔蘇生学
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Morioka Norimitsu
Department of Dental Pharmacology, Hiroshima University Graduate School of Biomedical Sciences, Japa
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Nakata Yoshihiro
Department of Pharmacology, Hiroshima University Graduate School of Biomedical Sciences, Japan
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Shiba Eri
Department Of Pharmacology Graduate School Of Biomedical Sciences Hiroshima University
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Tang He-bin
Coll. Of Pharmacy South-central Univ. For Nationalities Chn
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LI Yu-sang
Department of Pathology, Graduate School of Biomedical Sciences, Hiroshima University
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Li Yu-sang
Department Of Pathology Graduate School Of Biomedical Sciences Hiroshima University
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ZHENG Tai-Xing
Department of Neurophysiology, Graduate School of Biomedical Sciences, Hiroshima University
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OGATA Nobukuni
Department of Neurophysiology, Graduate School of Biomedical Sciences, Hiroshima University
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Nakata Yoshihiro
Graduate School Of Biomedical Sciences Hiroshima Univ.
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Morioka Norimitsu
Department Of Dental Pharmacology Hiroshima University Graduate School Of Biomedical Sciences
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Morioka Norimitsu
Department Of Pharmacology Graduate School Of Biomedical Sciences Hiroshima University
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Zheng Tai-xing
Department Of Neurophysiology Graduate School Of Biomedical Sciences Hiroshima University
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Ogata Nobukuni
Department Of Neurophysiology Graduate School Of Biomedical Sciences Hiroshima University
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Nakata Yoshihiro
Department Of Biophysics Gunma University
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Nakata Yoshihiro
Dep. Of Pharmacology Graduate School Of Biomedical Sciences Hiroshima Univ. Jpn
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Nakata Yoshihiro
Dep. Of Pharmacology Hiroshima Univ. Graduate School Of Biomedical Sciences Jpn
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Tang He-bin
Department Of Pharmacology College Of Pharmacy South-central University For Nationalities
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