CB_1 Cannabinoid Receptor Stimulation Modulates Transient Receptor Potential Vanilloid Receptor 1 Activities in Calcium Influx and Substance P Release in Cultured Rat Dorsal Root Ganglion Cells
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概要
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Cannabinoids have been reported to have analgesic properties in animals of acute nociception or of inflammatory and neuropathic pain models, but the mechanisms by which they exert such alleviative effects are not yet fully understood. We investigated whether the CB1-cannabinoid-receptor agonist HU210 modulates the capsaicin-induced 45Ca2+ influx and substance P like-immunoreactivity (SPLI) release in cultured rat dorsal root ganglion (DRG) cells. HU210 attenuated the capsaicin-induced 45Ca2+ influx and this effect was reversed by the CB1 antagonist AM251. Treatment of DRG cells with 100 nM bradykinin for 3 h potentiated capsaicin-induced SPLI release accompanied with the induction of cyclooxygenase-2 mRNA expression. The potentiation of SPLI release by bradykinin was reversed by HU210 or the protein kinase A (PKA) inhibitor H-89. HU210 also reduced forskolin-induced cyclic AMP production and forskolin-induced potentiation of SPLI release. These results suggest that CB1 could inhibit either the capsaicin-induced Ca2+ influx or the potentiation of capsaicin-induced SPLI release by a long-term treatment with bradykinin through involvement of a cyclic-AMP-dependent PKA pathway. In conclusion, CB1-receptor stimulation modulates the activities of transient receptor potential vanilloid receptor 1 in cultured rat DRG cells.
- 社団法人 日本薬理学会の論文
- 2005-03-20
著者
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Tang He-bin
Department Of Pharmacology Graduate School Of Biomedical Sciences Hiroshima University
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Tang He-bin
Department Of Pharmacology Division Of Clinical Pharmaceutical Sciences Programs Of Pharmaceutical S
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Nakata Yoshihiro
Department of Pharmacology, Hiroshima University Graduate School of Biomedical Sciences, Japan
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KAWAMOTO Masashi
Department of Anesthesiology and Critical Care Medicine, Division of Clinical Medical Science, Gradu
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YUGE Osafumi
Department of Anesthesiology and Critical Care Medicine, Division of Clinical Medical Science, Gradu
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OSHITA Kyoko
Department of Anesthesiology and Critical Care, Division of Clinical Medical Science, Graduate Schoo
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INOUE Atsuko
Department of Pharmacology, Division of Clinical Pharmaceutical Sciences, Programs of Pharmaceutical
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Inoue Atsuko
Department Of Pharmacology Division Of Clinical Pharmaceutical Sciences Programs Of Pharmaceutical S
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Inoue Atsuko
Department Of
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Yuge Osafumi
Department Of Anesthesiology And Critical Care Division Of Clinical Medical Science Graduate School
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Oshita Kyoko
Department Of Anesthesiology And Critical Care Division Of Clinical Medical Science Graduate School
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Nakata Yoshihiro
Department Of Biophysics Gunma University
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Kawamoto Masashi
Department Of Anesthesiology And Critical Care Division Of Clinical Medical Science Graduate School
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Nakata Yoshihiro
Department Of Pharmacology Division Of Clinical Pharmaceutical Sciences Programs Of Pharmaceutical S
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Yuge Osafumi
Department Of Anesthesiology And Critical Care Division Of Clinical Medical Science Graduate School
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Tang He-bin
Department Of Pharmacology College Of Pharmacy South-central University For Nationalities
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