Anti-allergic Substances Contained in the Pollen of Cryptomeria japonica Possess Diverse Effects on the Degranulation of RBL-2H3 Cellse
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概要
- 論文の詳細を見る
Following prolonged exposure to some of the flavonoids with RBL-2H3 cells, secretion of hexosaminidase, a granule constituent, stimulated by an immunologic was enhanced. RBL-2H3 cells do not normally respond to polybasic secretagogues, but as reported here, they do so after prolonged exposure. Effect of flavonoids on secretion of hexosaminidase was also investigated. Of the thirteen flavonoids, quercetin and fisetin were the most potent inhibitors. A structure-activity study indicated that the position, number, and substitution of the hydroxy group of the B ring and saturation of the C2-C3 bond are important factors affecting flavonoid inhibition of secretary granules in RBL-2H3 cells.
- 社団法人 日本薬理学会の論文
- 2003-07-01
著者
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Nakata Yoshihiro
Department of Pharmacology, Hiroshima University Graduate School of Biomedical Sciences, Japan
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YASUHARA Tadashi
Tokyo University of Agriculture
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Hide Izumi
Department of Molecular and Pharmacological Neuroscience, Graduate School of Biomedical Sciences, Hi
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AKIYAMA MITOSHI
Departments of Radiobiology, Radiation Effects Research
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SUGIMOTO Akiko
Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University
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Nakata Yoshihiro
Graduate School Of Biomedical Sciences Hiroshima Univ.
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Akiyama Mitoshi
Department Of Clinical Radiology Faculty Health Sciences Hiroshima International University
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INOUE Atsuko
Department of Pharmacology, Division of Clinical Pharmaceutical Sciences, Programs of Pharmaceutical
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Nakata Yoshihiro
Department Of Pharmacology Graduate School Of Biomedical Sciences Hiroshima University
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Inoue Atsuko
Department Of
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Sugimoto Akiko
Institute Of Biomaterials And Bioengineering Tokyo Medical And Dental University
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Sugimoto Akiko
Department Of Applied Chemistry Faculty Of Engineering Osaka University
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Hide Izumi
Department Of Pharmacology Graduate School Of Biomedical Sciences Hiroshima University
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MORIMOTO Yukiko
Department of Pharmacology, Institute of Pharmaceutical Sciences, Hiroshima University School of Med
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Morimoto Yukiko
Department Of
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Nakata Yoshihiro
Department Of Biophysics Gunma University
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Hide Izumi
Department Of Molecular And Pharmacological Neuroscience Graduate School Of Biomedical Sciences Hiro
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Yasuhara Tadashi
Junior Coll. Of Tokyo Univ. Of Agriculture
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Nakata Yoshihiro
Dep. Of Pharmacology Hiroshima Univ. Graduate School Of Biomedical Sciences Jpn
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