Modulation of the Substance P Release From Cultured Rat Primary Afferent Neurons by Zinc Ions
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概要
- 論文の詳細を見る
The present study was conducted to determine whether zinc ions are involved in the modulation of substance P release from cultured rat dorsal root ganglion (DRG) neurons. We show here that that lower concentrations (10−8 – 10−7 M) of zinc ions may evoke an extracellular Ca2+ influx through L-, N-, and T-type voltage-dependent Ca2+ channels, thereby increasing the substance P release from cultured DRG neurons, but higher concentrations (10−6 – 10−4 M) of zinc ions attenuate or even completely mask these responses. Zinc ions therefore seem to be an important modulator of substance P release from primary afferent neurons.
- 社団法人 日本薬理学会の論文
- 2009-07-20
著者
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Tang He-bin
Department Of Pharmacology Graduate School Of Biomedical Sciences Hiroshima University
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Tang He-bin
College Of Pharmacy South-central University For Nationalities
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Tang He-bin
広島大学 医歯薬学総合研究科麻酔蘇生学
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Nakata Yoshihiro
Department of Pharmacology, Hiroshima University Graduate School of Biomedical Sciences, Japan
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MIYANO Kanako
Department of Pharmacology, Graduate School of Biomedical Sciences, Hiroshima University
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Nakata Yoshihiro
Department Of Pharmacology Graduate School Of Biomedical Sciences Hiroshima University
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Miyano Kanako
Department Of Pharmacology Graduate School Of Biomedical Sciences Hiroshima University
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Nakata Yoshihiro
Department Of Biophysics Gunma University
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