Somatic Cell Mutations in Atomic Bomb Survivors : II. BIOLOGICAL EFFECTS

スポンサーリンク

概要

• 論文の詳細を見る

• Somatic mutations/GPA/HPRT/TcR/HLA Mutant frequencies in peripheral blood lymphocytes and erythrocytes have been measured for atomic bomb survivors having various DS86 doses. Among the four assay systems utilized so far, erythrocyte glycophorin A assay revealed a dose related increase of mutant frequency, similar to the results obtained with in vitro mutagenesis studies at HPRT locus using human diploid cells. Mutant T-lymphocyte frequency of the HPRT locus detected as resistant to 6-thioguanine significantly increased with DS86 dose however the slope was very shallow compared with that of in vitro study. Mutation at T-cell receptor genes and the HLA-A gene did not show a significant increase in frequency with dose in cells of survivors studied.

• 日本放射線影響学会の論文

著者

• HAKODA Masayuki

  Department of Nutritional Sciences, Faculty of Human Ecology, Yasuda Women's University

• Hakoda Masayuki

  Department Of Clinical Studies Radiation Effects Research Foundation

• Hakoda Masayuki

  放射線影響研究所

• Hirai Yuko

  Department of Molecular and Internal Medicine, Hiroshima University

• Nakamura Nori

  Dep. Of Genetics Radiation Effects Res. Foundation

• Nakamura Nori

  Genetics Radiation Effects Research Foundation

• Nakamura Nori

  Department Of Genetics Radiation Effects Research Foundation

• Hirai Y

  Dept. Of Radiobiology Rerf.

• Nakamura N

  Radiation Effects Res. Foundation Hiroshima Jpn

• AKIYAMA MITOSHI

  Departments of Radiobiology, Radiation Effects Research

• Hirai Yuko

  Department Of Radiobiology Radiation Effects Research Foundation

• Hirai Yuko

  Department Of Cerebrovascular Disease National Kyushu Medical Center

• Akiyama M

  Radiation Effects Research Foundation Dept. Of Radiobiology

• Akiyama Mitoshi

  Radiat. Effects Res. Found.

• Akiyama Mitoshi

  Department Of Clinical Radiology Faculty Health Sciences Hiroshima International University

• HIRAI Ynko

  Radiat. Effects Res. Found.

• KUSHUNOKI Yoichiro

  Radiat. Effects Res. Found.

• KYOIZUMI Seishi

  Radiat. Effects Res. Found.

• KUSUNOKI Yoichiro

  Department of Radiobiology/Molecular Epidemiology, Radiation Effects Research Foundation

• KYOIZUMI Seishi

  Department of Radiobiology, Radiation Effects Research Foundation

• KUSHIRO JUNICHI

  Department of Radiobiology, Radiation Effects Research Foundation

• Nakamura Nori

  Departemnt Of Radiation Oncology Faculty Of Medicine University Of Tokyo

• Kusunoki Y

  Department Of Radiobiology/molecular Epidemiology Radiation Effects Research Foundation

• Nakamura Nori

  Dept. Of Genetics Rerf

• Kushunoki Yoichiro

  Radiobiology Radiation Effects Res. Found.

• Kyoizumi Seishi

  Radiobiology Radiation Effects Res. Found.

• Kusunoki Yoichiro

  Radiobiology Radiation Effects Res. Found.

• Kyoizumi Seishi

  Dept. Radiobiol. And Mol. Epidemiol. Radiation Effects Res. Found.

• Kusunoki Yoichiro

  Department Of Radiobiology Radiation Effects Research Foundation

• Kushiro Junichi

  Department Of Radiobiology Radiation Effects Research Foundation

関連論文

• Combining effects of polymorphism of tumor necrosis factor α5'-flanking region and HLA-DRB1 on radiological progression in patients with rheumatoid arthritis
• PJ-134 Does ARB Valsartan Reduce Cardiac Events after Coronary Stenting? : Results of the Coronary Atherosclerosis Reduction Project (CARP) at 1-Year follow-up(Restenosis basic/clinical-3, The 71st Annual Scientific Meeting of the Japanese Circulation Soc
• PJ-134 Does ARB Valsartan Reduce Cardiac Events after Coronary Stenting? : Results of the Coronary Atherosclerosis Reduction Project (CARP) at 1-Year follow-up(Restenosis basic/clinical-3, The 71st Annual Scientific Meeting of the Japanese Circulation Soc
• Accumulation of Cells at G_2/M Stage by Low Dose-Rate Irradiation Renders the Cell Population More Susceptible to the Subsequent Induction of 6-Thioguanine-Resistant Mutations by ^Cf Fission Neutrons.
• OJ-153 Non-SCN5A Related Brugada Syndromes : Verification of Normal Splicing and Trafficking of SCN5A without Exonic Mutations(Arrhythmia, basic-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• Ablation of Idiopathic Ventricular Tachycardia with a Left Bundle-Branch Block Morphology Originating from the Pulmonary Artery
• Reversible Posterior Leukoencephalopathy Syndrome in a Postpartum Woman without Eclampsia
• Radiation sensitivity and genomic instability in the hematopoietic system : Frequencies of micronucleated reticulocytes in whole-body X-irradiated BALB/c and C57BL/6 mice
• Perspectives on cancer immuno-epidemiology
• New Genomic Approach in Diagnosing Brugada Syndrome using Zn^-cyclen Complex (Arrhythmia, Basic 5 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-207 Female Sex Hormones Retard Aging Changes in Autonomic Nervous Activities(Autonomic Nervous System 2 (H) : OJ23)(Oral Presentation (Japanese))
• Possible Involvement of Long Chain Fatty Acids in the Spores of Ganoderma lucidum (Reishi Houshi) to Its Anti-tumor Activity(Pharmacology)
• Genetic Effects of Radiation in Atomic-bomb Survivors and Their Children : Past, Present and Future
• Teratogenicity of Tritium Water to Rat Embryos
• Anti-Human T-Lymphotropic Virus Type-I Antibodies in Atomic-Bomb Survivors
• Cell Cycle and LET Dependence for Radiation-induced Mutation : A Possible Mechanism for Reversed Dose-rate Effect
• X-Irradiation Induces Up-regulation of ATM Gene Expression in Wild-type Lymphoblastoid Cell Lines, but Not in Their Heterozygous or Homozygous Ataxia-telangiectasia Counterparts
• Mitochondrial DNA Deletion in Human CelLB Exposed to Radiation.
• Assessment of Radiation Effect on Germline Mutation in Mice Based on Whole Genome Scanning by Two-Dimensional DNA Gel
• Study of Spontaneous and X-Ray Induced Germ Cell Mutations in Mice by 2-D DNA Gel Analysis : III. Estimate of Doubling Dose
• T-cell differentiation from one HPRT mutant stem cell in a male A-bomb survivor.
• Approaches to molecular analysis of mutant glycophorin A(GPA) genes in erythroblasts and reticulocytes.
• SAFE-HANDLING OF TRITIATED WATER : HOOD, MONITORING AND INVENTORY
• Alkaline Denaturation of Dentin-A Simple Way to Isolate Human Tooth Enamel for Electron Spin Resonance Dosimetry
• Somatic Mutant Fraction and Cancer Risk in Atomic Bomb Survivors
• Association between inflammatory and infectious markers among Atomic Bomb Survivors; Implication for mechanism of increase in cardiovascular disease.
• Atherosclerosis-Related Microbial Infection in Atomic Bomb Survivors
• Somatic Cell Mutations in Atomic Bomb Survivors : II. BIOLOGICAL EFFECTS
• In Vitro Culture of Human Thyroid Cells; Methods and Application to Radiation Biology
• EFFECT OF TRITIATED WATER ON GERM CELLS AND FERTILITY : A COMPARATIVE STUDY WITH TRITIUM SIMULATION USING OOCYTE DEATH OF MOUSE NEWBORNS AS INDEX
• 5 Late Effects of Atomic Bomb Radiation on Plasma Inflammatory Cytokines(Atomic bomb effects, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• O-17. Is there evidence for genetic instabilities in lymphocytes of A-bomb survivors? : chromosome analysis of clonally expanded T-cell populations by M-FISH method(Abstracts of the oral and poster presentations,Abstracts of the 55th Annual Meeting of the
• O-16. Radiation-induced translocations in T cells of Hiroshima A-bomb survivors(Abstracts of the oral and poster presentations,Abstracts of the 55th Annual Meeting of the Society of Chromosome Research)
• 55 Chromosome Aberrations, Clone Formation, and Leukemia(Chromosome aberrations, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• 4 Fetal Mice are Resistant to Radiation-Induced Translocations(Atomic bomb effects, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• Chromosome Aberration Frequency in the Survivors Exposed in Utero : Are Lymphocytes in the Fetus Radioresistant for the Induction of Chromosome Aberrations?
• Origin of Clonal Chromosome Aberrations in Lymphocytes of A-bomb Survivors. Part 2 : CD4 and CD8 T-cells
• Random Location of Human Chromosomes in Interphase Nuclei
• Chromosome aberration : Inv(14)(q11q32) in lymphocytes from Hiroshima A-bomb survivors
• S-values are not a signature for a significant contribution of neutrons to the radiation dose received by atomic-bomb survivors.
• Fingerprint of High LET radiation (F-value) for chromosome aberration and radiation effects of atomic bomb.
• Detection of clonal chromosome aberrations by FISH in the A-bomb survivors.
• Evaluation of possible population bias among high-dose atomic-bomb survivors in the frequency of the HLA Class II gene types.
• Translocation breakpoints distribute less frequently in chromosome terminal portion in lymphocytes of A-bomb survivors
• Establishment of an in vivo somatic mutation assay at the T-cell receptor gene in the mouse.
• Current Summary of Lymphocyte Survival Study : II. BIOLOGICAL EFFECTS
• Life-span of human memory T cells estimated by T-cell receptor mutations induced by radiation exposure.
• SOMATIC CELL MUTATIONS AT THE GLYCOPHORIN A LOCUS IN ERYTHROCYTES OF ATOMIC BOMB SURVIVORS : IMPLICATIONS FOR CANCER RISK.
• Statistical Approach to Predict Presence of Clonal Chromosome Aberrations
• Why Cancer Risks in A-Bomb Survivors Levels Off above 2 Sv?
• Chromosome Aberrations and Genetic Instability in Lymphocytes from A-Bomb Survivors
• Frequencies of Stable Chromosome Aberrations in Atomic Bomb Survivors-New Insights of Dose ResponseCurves by Shielding Categories
• T-lymphocyte Stem Cell Structure Deduced from Clonal Chromosome Aberrations
• FISH examination of blood lymphocytes from Mayak nuclear workersNori NAKAMURA1, L. E. BURAK2, Yoshiaki KODAMA1, Mimako NAKANO1, Kazuo OHTAKI1, Masahiro
• DOES THE CHROMOSOME ABERRATION DOSE RESPONSE VARY DEPENDING ON THE DIRECTION FROM THE HYPOCENTER?
• Atomic-Bomb Survivor Cancer Data and Their Interpretation
• Detection of Spontaneous and X-ray Induced Germ Cell Mutations in Mice by Computer Assisted Two-Dimensional DNA Gel Analysis
• Identification of clonal chromosome aberrations by repeated lymphocyte tests in A-bomb survivors.
• Clustering of interstitial deletions on chromosome 5q in the lymphocytes from atomic-bomb survivors.
• Dose-response relationship for frequencies of stable chromosome aberrations in A-bomb survivors - Variation in dose-response curves by shielding categories.
• Induction of 6-thioguanine-resistant mutations by ^Cf fission neutrons in the cells pre-irradiated at low dose-rate.
• Estimation of minimum length of translocated chromosome tips detectable by FISH.
• Comparison of iranslocation frequencies between FISH and conventional methods in lymphocytes from A-bomb survivors.
• Detection of Ataxia telangiectasia mutated (ATM) gene product. Yuko
• Effect of ionizing radiation on mitochondrial memebrance potential in human peripheral lymphocyte subpopulations.
• Molecular analysis of mutant Fc γ receptor III (Fc γ R III) gene in neutrophils.
• Development of a Nobel Assay System to Detect Human Somatic Mutations Using Neutrophils. I. At the Fcy Receptor III Locus
• Flow-cytometric measurements for subsets of T, B, and NK cells among atomic-bonib survivors.
• Risks of diabetes and HLA types among atomic-bomb survivors
• Noninvasive Detection of Obstructive Coronary Artery Disease Using Coronary Calcification Adding C-Reactive Protein in Symptomatic Patients (Angina Pectoris, Basic/Clinical 2 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-116 The Association of Seropositivity to Chlamydia pneumoniae, Helicobacter pylori, and Cytomegalovirus with the Development of Hypertension in Japanese-Americans(Hypertension, Clinical 2 (H) : PJ20)(Poster Session (Japanese))
• Pressure-Induced Phase Transitions in trans-Stilbene Crystals
• Contamination from Possible Solar Light Exposures in ESR Dosimetry Using Human Tooth Enamel
• RBE OF TRITIUM BETA-RAYS FOR CELL KILLING OF NORMAL HUMAN CELLS IN VITRO
• INTRACELLULAR DAMAGE OF DNA INDUCED BY TRITIATED WATER AND ITS RESTORATION
• Future Perspective of Radiobiological Studies : III. FUTURE PERSPECTIVE
• Activated RET Oncogene in Thyroid Cancer of Children Residing in Area Contaminated by the Chernobyl Accident
• Detection of Hepatis B Virus in Liver Cancer among Atomic-bomb Survivors
• Anti-allergic Substances Contained in the Pollen of Cryptomeria japonica Possess Diverse Effects on the Degranulation of RBL-2H3 Cellse
• Overview of Immunological Studies on A-bomb Survivors : II. BIOLOGICAL EFFECTS
• T-Cell Responses to Staphylococcus Aureus Toxins in A-bomb Survivors
• Role of Caspases and Reactive Oxygen in Radiation-Induced Apoptosis : Comparison with Fas-Mediated Apoptosis
• A Hypothesis on Radiation-Induced Immunity Polarization and Its Relation to Disease Development in Atomic-Bomb Survivors
• Effect of Atomic-Bomb Radiation on Cytokine and Immunoglobulin levels
• A Novel SCID Mouse Model for Studying Spontaneous Metastasis of Human Lung Cancer to Human Tissue
• Search for the BCR-ABL Gene in the Peripheral Blood of A-bomb Survivors and Radioiherapeutic Patients
• The SCID-hu Mouse Model for Human Radiation Biology : Establishing an Epilation Model
• Flow Cytometric Detection of Mouse T Cells Lacking Expression of the Major Histocompatibility Complex Antigen Class I Allele
• Autoantibodies and immunoglobulins among atomic bomb survivors.
• Electron Spin Resonance Analysis of Tooth Enamel Does not Indicate Exposures to Large Radiation Doses in a Large Proportion of Distally-exposed A-bomb Survivors
• Biexponential Signal Attenuation Analysis of Diffusion-weighted Imaging of Breast
• ESR dose estimation using tooth enamel from Hiroshima A-bomb survivors. III.Results of 69 survivors for correlation between stable chromosome aberration frequency and ESR signal intensity.
• ESR dose estimation using tooth enamel from Hiroshima A-bomb survivors. II. Correlation between stable chromosome aberration frequency vs ESR signal intensity.
• Electron Spin Resonance Analysis of Tooth Enamel Does not Indicate Exposures to Large Radiation Doses in a Large Proportion of Distally-exposed A-bomb Survivors
• Radiation dose estimation by ESR on tooth enamel from Hiroshima A-bomb survivors. Part 1 : Preservation and preparation of the materials.
• 79. A Clinical Study of Preventing the Infantile Deveolopment of HBsAg Carrier State by HBV Maternoinfantile Vertical Transmission : The Efficacy of Combined Passive and Active Immunization in Relation to Initiating Vaccination Periods
• Preoperative Diagnosis of Endometrial Carcinoma by Enhanced CT
• Clinical Study on Clear Cell Carcinoma of the Ovary
• Reversible Posterior Leukoencephalopathy Syndrome in a Postpartum Woman without Eclampsia
• Isolation of Substance P Binding Protein from Rat Brain.

もっと見る 閉じる

スポンサーリンク