<SESSION>EFFECT OF TRITIATED WATER ON GERM CELLS AND FERTILITY : A COMPARATIVE STUDY WITH TRITIUM SIMULATION USING OOCYTE DEATH OF MOUSE NEWBORNS AS INDEX

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概要

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• The relative biological effectiveness (RBE) of tritiated water (HTO) was sought by comparison with the results of tritium simulation using Cs-137 and the results obtained by irradiating with Co-60 gamma rays and fission neutrons (Cf-252) for reference, using as index the lethal effect on mouse newborn oocytes. The method was to inject various doses of HTO once into the abdominal cavity of ICR mouse on the 14th day after birth and the survival rate of oocytes were calculated. As a result, the number of surviving oocytes decreased exponentially depending on the dose of HTO or CS-137,and 1.1-3.5 was given as the RBE. Further, the results of the tests with Co-60 and Cf-252 that were made for reference showed the lethal effect on oocytes to be stronger in the order of Cf-252,HTO, Co-60 and Cs-137. The effects of HTO and Cs-137 on the reproductive capacity (RC) were also studied raising the female mice which were exposed to HTO or Cs-137 as same procedure. The mice were delivered of litters four times in two years. The HTO or Cs-137 induced diminution of RC may be dose dependent and seems to be non-stochastic

• 核融合科学研究所の論文

著者

• OHTAKI Megu

  Department of Envirometrics and Biometrics, Research Institute for Radiation Biology and Medicine, H

• OHTAKI MEGU

  Research Institute for Radiation Biology and Medicine, Hiroshima University

• Ohtaki M

  Hiroshima Univ. Hiroshima Jpn

• Ohtaki Megu

  Department Of Environment And Biometrics Research Institute For Radiation Biology And Medicine Hiros

• Nakamura Nori

  Department Of Genetics Radiation Effects Research Foundation

• Hori Hiroshi

  KYOKUGEN, Osaka Univ.

• Satow Y

  Hiroshima Univ. Hiroshima

• Satow Yukio

  Dept. Of Environment &mutation. Hiroshima Univ.

• Satow Yukio

  Department Of Envrironment And Mutation Division Of Envrionmental Biology Research Institute For Rad

• Satow Yukio

  Department Of Environment And Mutation Research Institute For Radiation Biology And Medicine Hiroshi

• Hori Hiroshi

  Department of Biology, Nagoya University

• Hori H

  Kyokugen Osaka Univ.

• Hori Hiroshi

  Department Of Applied Biological Chemistry Tamagawa University

• Hori Hiroshi

  Kyokugen Osaka Univ.

• Nakamura Nori

  Departemnt Of Radiation Oncology Faculty Of Medicine University Of Tokyo

• Ohtaki Megu

  Department Of Biometrics Research Institute For Nuclear Medicine And Biology Hiroshima University

• HORI Hiroshi

  Department of Agricultural Chemistry, Faculty of Agriculture, Tamagawa University

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