<SESSION>INTRACELLULAR DAMAGE OF DNA INDUCED BY TRITIATED WATER AND ITS RESTORATION
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概要
- 論文の詳細を見る
Induction and repair of DNA breaks were studied in mouse L5178Y cells after exposure to tritiated water (HTO) or X-rays. The amount of DNA breaks immediately after HTO-treatment was linearly increased to the dose and was smaller than the initial breaks by X-rays; RBE was 0.6. Repair profiles of DNA breaks revealed that HTO-induced breaks contained a larger proportion of slow/non-reparable components. The dose response curves of non-reparable breaks, which were determined 10hr after HTO-treatment or X-irradiation, were curvilinear and overlapped each other. These results indicate that RBEs of HTO previously reported for cell killing (1.0) and mutagenesis (1.2-1.3) were correlated with the amount of remaining breaks but not by the initial breaks.
- 核融合科学研究所の論文
著者
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Suzuki Norio
Department of Biological Sciences, Graduate School of Science, The University of Tokyo
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Nakamura Nori
Department Of Genetics Radiation Effects Research Foundation
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Sakai K
Resarch Center For Radiation Protection National Institute Of Radiological Sciences
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Suzuki N
Toshiba Corp. Kawasaki Jpn
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Suzuki N
Hokkaido Univ. Sapporo Jpn
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SAKAI KAZUO
Department of Radiation Oncology, Graduate School of Medicine, University of Tokyo
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Nakamura Nori
Departemnt Of Radiation Oncology Faculty Of Medicine University Of Tokyo
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OKADA SHIGEFUMI
Department of Radiation Oncology, Faculty of Medicine, University of Tokyo
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Okada Shigefumi
Departemnt Of Radiation Biology Center Kyoto University
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Suzuki N
Department Of Surgery Gunma Children's Medial Center
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Suzuki Norio
Department Of Biological Sciences Graduate School Of Science Hokkaido University
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SAKAI Kazuo
School of Law, Meiji University
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Sakai Kazuo
Department Of Physics Faculty Of Science Science University Of Tokyo
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Suzuki Norio
Department Of Agricultural Chemistry The University Of Tokyo
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Sakai Kazuo
Department of Computer Science and Media Engineering, Faculty of Engineering, Yamanashi University
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