Identification and Characterization of a Protein Found After X-Irradiation in Human T Cell Leukemia

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概要

• 論文の詳細を見る

• An X-ray-induced protein in human T cell leukemia MOLT-4 cells is described. It was detected 4 hrs after irradiation by two dimensional gel electrophoresis and silver staining. The location is 41 kDa in the mass and 4.0 of pI. Its spots were collected from the gels and microsequenced. The protein was identified from its partial sequences as a set gene product, whose gene translocation previously was found in a case of acute undifferentiated leukemia. Polyclonal rabbit antibodies stained two spots, the 41 kDa (p 41) and the 42 kDa (p 42) proteins. Photoimage analyses of the silver-stained gels and Western blots indicated that the induction of p 41 was time dependent, starting 4 hrs after irradiation and reaching a plateau by 10 hrs, and was dose dependent between 1 and 10 Gy. p 41 appeared somewhat ahead of cell death, as determined by the dye exclusion test, but the role in that cell process has yet to be clarified.

• 日本放射線影響学会の論文

著者

• Suzuki N

  Dept. Radiat. Oncol. Grad. Sch. Med. Univ. Tokyo

• Suzuki Norio

  Department of Biological Sciences, Graduate School of Science, The University of Tokyo

• Sakai K

  Resarch Center For Radiation Protection National Institute Of Radiological Sciences

• Suzuki Norio

  東京大学 医系研究 救急医

• MATSUMOTO Yoshihisa

  Department of Mechanical Engineering, Oita National College of Technology

• HIRANO Kazuya

  Lab. Public Health. Sch. Pharmacy and Life Science.

• HIRANO KAZUYA

  Department of Radiation Oncology, Graduate School of Medicine, University of Tokyo

• SAKAI KAZUO

  Department of Radiation Oncology, Graduate School of Medicine, University of Tokyo

• Matsumoto Yukiko

  Radiat. Biol. Kyoto Univ.

• Matsumoto Yoshihisa

  Department Of Anesthesiology And Intensive Care Medicine Graduate School Of Medical Science Kanazawa

• Morita Akinori

  Depts. Radiat. Res. And Radiat. Oncol. Grad. Sch. Med. Univ. Tokyo

• Matsumoto Yoshihisa

  Res. Lab. For Nuclear Reactors And Dep. Of Nuclear Engineering Tokyo Inst. Of Technol.

• MORIMATSU AKESHI

  Department of Radiation Oncology, Faculty of Medicine, University of Tokyo

• Suzuki Norio

  Department Of Biological Sciences Graduate School Of Science Hokkaido University

• Sakai Kazuo

  Department Of Physics Faculty Of Science Science University Of Tokyo

• Matsumoto Yoshihisa

  Atomic Bomb Disease Institute Graduate School Of Biochemical Sciences Nagasaki University

• Suzuki Norio

  Department Of Agricultural Chemistry The University Of Tokyo

• SAKATA Koh-ichi

  Department of Physics, Hiroshima University

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